Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain

Cadmium (Cd) produces cognition decline following single and repeated treatment, although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic neurons innervate the cortex and hippocampus, regulating cognition. Cd single and repeated exposure induced BF cholinergic neuronal...

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Autores: Sola Vendrell, Emma, Moyano-Cires Ivanoff, Paula Viviana, Flores A, García Sánchez, José Manuel, García Lobo, Jimena, Anadón Baselga, María José, Frejo Moya, María Teresa, Pelayo Alarcón, Adela, Fernández Fernández, María De La Cabeza, Pino Sans, Javier Del
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/115389
Acceso en línea:https://hdl.handle.net/20.500.14352/115389
Access Level:acceso abierto
Palabra clave:615.9
Cadmium
Basal forebrain cholinergic neurons
Inflammatory cytokines
Aβ and Tau proteins
T3
Oxidative stress
Toxicología (Medicina)
3214 Toxicología
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrainSola Vendrell, EmmaMoyano-Cires Ivanoff, Paula VivianaFlores AGarcía Sánchez, José ManuelGarcía Lobo, JimenaAnadón Baselga, María JoséFrejo Moya, María TeresaPelayo Alarcón, AdelaFernández Fernández, María De La CabezaPino Sans, Javier Del615.9CadmiumBasal forebrain cholinergic neuronsInflammatory cytokinesAβ and Tau proteinsT3Oxidative stressToxicología (Medicina)3214 ToxicologíaCadmium (Cd) produces cognition decline following single and repeated treatment, although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic neurons innervate the cortex and hippocampus, regulating cognition. Cd single and repeated exposure induced BF cholinergic neuronal loss, partly through thyroid hormones (THs) disruption, which may cause the cognition decline observed following Cd exposure. However, the mechanisms through which THs disruption mediate this effect remain unknown. To research the possible mechanisms through which Cd-induced THs deficiency may mediate BF neurodegeneration, Wistar male rats were treated with Cd for 1- (1 mg/kg) or 28-days (0.1 mg/kg) with or without triiodothyronine (T3, 40 μg/kg/day). Cd exposure promoted neurodegeneration, spongiosis, gliosis and several mechanisms related to these alterations (increased H202, malondialdehyde, TNF-α, IL-1β, IL-6, BACE1, Aβ and phosphorylated-Tau levels, and decreased phosphorylated-AKT and phosphorylated-GSK-3β levels). T3 supplementation partially reversed the effects observed. Our results show that Cd induces several mechanisms that may be responsible for the neurodegeneration, spongiosis and gliosis observed in the rats’ BF, which are partially mediated by a reduction in THs levels. These data may help to explain the mechanisms through which Cd induces BF neurodegeneration, possibly leading to the cognitive decline observed, providing new therapeutic tools to prevent and treat these damages.ElsevierUniversidad Complutense de Madrid20232023-02-2820232023-02-28journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/115389reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1153892026-06-02T12:44:21Z
dc.title.none.fl_str_mv Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
title Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
spellingShingle Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
Sola Vendrell, Emma
615.9
Cadmium
Basal forebrain cholinergic neurons
Inflammatory cytokines
Aβ and Tau proteins
T3
Oxidative stress
Toxicología (Medicina)
3214 Toxicología
title_short Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
title_full Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
title_fullStr Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
title_full_unstemmed Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
title_sort Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
dc.creator.none.fl_str_mv Sola Vendrell, Emma
Moyano-Cires Ivanoff, Paula Viviana
Flores A
García Sánchez, José Manuel
García Lobo, Jimena
Anadón Baselga, María José
Frejo Moya, María Teresa
Pelayo Alarcón, Adela
Fernández Fernández, María De La Cabeza
Pino Sans, Javier Del
author Sola Vendrell, Emma
author_facet Sola Vendrell, Emma
Moyano-Cires Ivanoff, Paula Viviana
Flores A
García Sánchez, José Manuel
García Lobo, Jimena
Anadón Baselga, María José
Frejo Moya, María Teresa
Pelayo Alarcón, Adela
Fernández Fernández, María De La Cabeza
Pino Sans, Javier Del
author_role author
author2 Moyano-Cires Ivanoff, Paula Viviana
Flores A
García Sánchez, José Manuel
García Lobo, Jimena
Anadón Baselga, María José
Frejo Moya, María Teresa
Pelayo Alarcón, Adela
Fernández Fernández, María De La Cabeza
Pino Sans, Javier Del
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.9
Cadmium
Basal forebrain cholinergic neurons
Inflammatory cytokines
Aβ and Tau proteins
T3
Oxidative stress
Toxicología (Medicina)
3214 Toxicología
topic 615.9
Cadmium
Basal forebrain cholinergic neurons
Inflammatory cytokines
Aβ and Tau proteins
T3
Oxidative stress
Toxicología (Medicina)
3214 Toxicología
description Cadmium (Cd) produces cognition decline following single and repeated treatment, although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic neurons innervate the cortex and hippocampus, regulating cognition. Cd single and repeated exposure induced BF cholinergic neuronal loss, partly through thyroid hormones (THs) disruption, which may cause the cognition decline observed following Cd exposure. However, the mechanisms through which THs disruption mediate this effect remain unknown. To research the possible mechanisms through which Cd-induced THs deficiency may mediate BF neurodegeneration, Wistar male rats were treated with Cd for 1- (1 mg/kg) or 28-days (0.1 mg/kg) with or without triiodothyronine (T3, 40 μg/kg/day). Cd exposure promoted neurodegeneration, spongiosis, gliosis and several mechanisms related to these alterations (increased H202, malondialdehyde, TNF-α, IL-1β, IL-6, BACE1, Aβ and phosphorylated-Tau levels, and decreased phosphorylated-AKT and phosphorylated-GSK-3β levels). T3 supplementation partially reversed the effects observed. Our results show that Cd induces several mechanisms that may be responsible for the neurodegeneration, spongiosis and gliosis observed in the rats’ BF, which are partially mediated by a reduction in THs levels. These data may help to explain the mechanisms through which Cd induces BF neurodegeneration, possibly leading to the cognitive decline observed, providing new therapeutic tools to prevent and treat these damages.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-02-28
2023
2023-02-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/115389
url https://hdl.handle.net/20.500.14352/115389
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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