VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients

Jimenez-Sousa, MA; Jimenez, JL; Fernandez-Rodriguez, A; Brochado-Kith, O; Bellon, JM; Bernal-Morell, E; Munoz-Fernandez, MA; Resino, S; del Amo, J; Navarro, ML; Gonzalez, MI; Blanco, JL; Gonzalez, J; Del Amo, J; Jarrin, I; Alejos, B; Hernando, V; Moreno, C; Iniesta, C; Sousa, LMG; Perez, NS; Garcia-Merino, IM; Fernandez, IC; Rico, CG; de la Fuente, JG; Concejo, PP; Portilla, J; Merino, E; Reus, S; Boix, V; Giner, L; Gadea, C; Portilla, I; Pampliega, M; Diez, M; Rodriguez, JC; Sanchez-Paya, J; Gomez, JL; Hernandez, J; Aleman, MR; Alonso, MD; Hernandez, MI; Diaz-Flores, F; Garcia, D; Pelazas, R; Lirola, AL; Rubio, R; Pulido, F; Bisbal, O; Hernando, A; Dominguez, L; Crestelo, DR; Bermejo, L; Santacreu, M; Iribarren, JA; Arrizabalaga, J; Aramburu, MJ; Camino, X; Rodriguez-Arrondo, F; von Wichmann, MA; Tome, LP; Goenaga, MA; Bustinduy, MJ; Azkune, H; Ibarguren, M; Lizardi, A; Kortajarena, X; Gutierrez, F; Masia, M; Padilla, S; Navarro, A; Montolio, F; Robledano, C; Colome, JG; Adsuar, A; Pascual, R; Fernandez, M; Garcia, E; Garcia, JA; Barber, X; Berenguer, J; de Quiros, JCLB; Gutierrez, I; Ramirez, M; Padilla, B; Gijon, P; Aldamiz-Echevarria, T; Tejerina, F; Parras, FJ; Balsalobre, P; Diez, C; Latorre, LP; Vidal, F; Peraire, J; Vilades, C; Veloso, S; Vargas, M; Lopez-Dupla, M; Olona, M; Rull, A; Rodriguez-Gallego, E; Alba, V; Alonso, MM; Aldeguer, JL; Julia, MB; Pitarch, MT; Hernandez, IC; Munoz, EC; Tovar, SC; Lleti, MS; Navarro, JF; Gonzalez-garcia, J; Arnalich, F; Arribas, JR; de la Serna, JIB; Castro, JM; Escosa, L; Herranz, P; Hontanon, V; Garcia-Bujalance, S; Lopez-Hortelano, MG; Gonzalez-Baeza, A; Martin-Carbonero, ML; Mayoral, M; Mellado, MJ; Mican, RE; Montejano, R; Montes, ML; Moreno, V; Perez-Valero, I; Rodes, B; Sainz, T; Sendagorta, E; Alcariz, NS; Valencia, E; Blanco, JR; Oteo, JA; Ibarra, V; Metola, L; Sanz, M; Perez-Martinez, L; Dalmau, D; Jaen, A; Sanmarti, M; Cairo, M; Martinez-Lacasa, J; Velli, P; Font, R; Xercavins, M; Alonso, N; Rivero, M; Reparaz, J; de Alda, MGR; Cano, MTD; de Galarreta, BPR; Segura, F; Amengual, MJ; Navarro, G; Sala, M; Cervantes, M; Pineda, V; Calzado, S; Navarro, M; de los Santos, I; Sanz, JS; Aparicio, AS; Cepeda, CS; Fraile, LGF; Gayo, EM; Moreno, S; Casado, JL; Dronda, F; Moreno, A; Elias, MJP; Ayerbe, CG; Gutierrez, C; Madrid, N; Terron, SD; Marti, P; Ansa, U; Serrano, S; Vivancos, MJ; Bernal, E; Cano, A; Garcia, AA; Urbieta, JB; Munoz, A; Alcaraz, MJ; Villalba, MD; Garcia, F; Pena, A; Munoz, L; Casas, P; Alvarez, M; Chueca, N; Vinuesa, D; Martinez-Montes, C; Del Romero, J; Rodriguez, C; Puerta, T; Carrio, JC; Vera, M; Ballesteros, J; Ayerdi, O; Riera, M; Penaranda, M; Leyes, M; Ribas, MA; Campins, AA; Vidal, C; Fanjul, F; Murillas, J; Homar, F; Santos, J; Viciana, I; Palacios, R; Gonzalez, CM; Viciana, P; Espinosa, N; Lopez-Cortes, LF; Podzamczer, D; Ferrer, E; Imaz, A; Tiraboschi, J; Silva, A; Saumoy, M; Olalla, J; del Arco, A; de la Torre, J; Prada, JL; Guerrero, JMGD; Stachowski, JP; Martinez, OJ; Vera, FJ; Martinez, L; Garcia, J; Alcaraz, B; Jimeno, A; Iglesias, AC; Souto, BP; de Cea, AM; Galera, C; Albendin, H; Perez, A; Iborra, A; Merlos, MA; Vidal, A; Suarez-Garcia, I; Malmierca, E; Gonzalez-Ruano, P; Rodrigo, DM; Mohamed-Balghata, MO; Vidal, MAG; Perez, VE; Molina, MJT; Garcia, JV; Moreno, JPS; Gorgolas, M; Cabello, A; Alvarez, B; Prieto, L; Moreno, JS; Caso, AA; Gutierrez, CH; Mena, MN; Puerto, MJG; Vilalta, RF; Ribera, AF; Roman, AR; Herrero, MTB; Juarez, AR; Lopez, PL; Sanchez, IM; Martinez, JP; Jimenez, MC; Perea, RT; Ruiz-Capillas, JJJ; Pineda, JA

VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients

Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in a...

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Detalles Bibliográficos
Autores:	Jimenez-Sousa, MA, Jimenez, JL, Fernandez-Rodriguez, A, Brochado-Kith, O, Bellon, JM, Bernal-Morell, E, Munoz-Fernandez, MA, Resino, S, del Amo, J, Navarro, ML, Gonzalez, MI, Blanco, JL, Gonzalez, J, Del Amo, J, Jarrin, I, Alejos, B, Hernando, V, Moreno, C, Iniesta, C, Sousa, LMG, Perez, NS, Garcia-Merino, IM, Fernandez, IC, Rico, CG, de la Fuente, JG, Concejo, PP, Portilla, J, Merino, E, Reus, S, Boix, V, Giner, L, Gadea, C, Portilla, I, Pampliega, M, Diez, M, Rodriguez, JC, Sanchez-Paya, J, Gomez, JL, Hernandez, J, Aleman, MR, Alonso, MD, Hernandez, MI, Diaz-Flores, F, Garcia, D, Pelazas, R, Lirola, AL, Rubio, R, Pulido, F, Bisbal, O, Hernando, A, Dominguez, L, Crestelo, DR, Bermejo, L, Santacreu, M, Iribarren, JA, Arrizabalaga, J, Aramburu, MJ, Camino, X, Rodriguez-Arrondo, F, von Wichmann, MA, Tome, LP, Goenaga, MA, Bustinduy, MJ, Azkune, H, Ibarguren, M, Lizardi, A, Kortajarena, X, Gutierrez, F, Masia, M, Padilla, S, Navarro, A, Montolio, F, Robledano, C, Colome, JG, Adsuar, A, Pascual, R, Fernandez, M, Garcia, E, Garcia, JA, Barber, X, Berenguer, J, de Quiros, JCLB, Gutierrez, I, Ramirez, M, Padilla, B, Gijon, P, Aldamiz-Echevarria, T, Tejerina, F, Parras, FJ, Balsalobre, P, Diez, C, Latorre, LP, Vidal, F, Peraire, J, Vilades, C, Veloso, S, Vargas, M, Lopez-Dupla, M, Olona, M, Rull, A, Rodriguez-Gallego, E, Alba, V, Alonso, MM, Aldeguer, JL, Julia, MB, Pitarch, MT, Hernandez, IC, Munoz, EC, Tovar, SC, Lleti, MS, Navarro, JF, Gonzalez-garcia, J, Arnalich, F, Arribas, JR, de la Serna, JIB, Castro, JM, Escosa, L, Herranz, P, Hontanon, V, Garcia-Bujalance, S, Lopez-Hortelano, MG, Gonzalez-Baeza, A, Martin-Carbonero, ML, Mayoral, M, Mellado, MJ, Mican, RE, Montejano, R, Montes, ML, Moreno, V, Perez-Valero, I, Rodes, B, Sainz, T, Sendagorta, E, Alcariz, NS, Valencia, E, Blanco, JR, Oteo, JA, Ibarra, V, Metola, L, Sanz, M, Perez-Martinez, L, Dalmau, D, Jaen, A, Sanmarti, M, Cairo, M, Martinez-Lacasa, J, Velli, P, Font, R, Xercavins, M, Alonso, N, Rivero, M, Reparaz, J, de Alda, MGR, Cano, MTD, de Galarreta, BPR, Segura, F, Amengual, MJ, Navarro, G, Sala, M, Cervantes, M, Pineda, V, Calzado, S, Navarro, M, de los Santos, I, Sanz, JS, Aparicio, AS, Cepeda, CS, Fraile, LGF, Gayo, EM, Moreno, S, Casado, JL, Dronda, F, Moreno, A, Elias, MJP, Ayerbe, CG, Gutierrez, C, Madrid, N, Terron, SD, Marti, P, Ansa, U, Serrano, S, Vivancos, MJ, Bernal, E, Cano, A, Garcia, AA, Urbieta, JB, Munoz, A, Alcaraz, MJ, Villalba, MD, Garcia, F, Pena, A, Munoz, L, Casas, P, Alvarez, M, Chueca, N, Vinuesa, D, Martinez-Montes, C, Del Romero, J, Rodriguez, C, Puerta, T, Carrio, JC, Vera, M, Ballesteros, J, Ayerdi, O, Riera, M, Penaranda, M, Leyes, M, Ribas, MA, Campins, AA, Vidal, C, Fanjul, F, Murillas, J, Homar, F, Santos, J, Viciana, I, Palacios, R, Gonzalez, CM, Viciana, P, Espinosa, N, Lopez-Cortes, LF, Podzamczer, D, Ferrer, E, Imaz, A, Tiraboschi, J, Silva, A, Saumoy, M, Olalla, J, del Arco, A, de la Torre, J, Prada, JL, Guerrero, JMGD, Stachowski, JP, Martinez, OJ, Vera, FJ, Martinez, L, Garcia, J, Alcaraz, B, Jimeno, A, Iglesias, AC, Souto, BP, de Cea, AM, Galera, C, Albendin, H, Perez, A, Iborra, A, Merlos, MA, Vidal, A, Suarez-Garcia, I, Malmierca, E, Gonzalez-Ruano, P, Rodrigo, DM, Mohamed-Balghata, MO, Vidal, MAG, Perez, VE, Molina, MJT, Garcia, JV, Moreno, JPS, Gorgolas, M, Cabello, A, Alvarez, B, Prieto, L, Moreno, JS, Caso, AA, Gutierrez, CH, Mena, MN, Puerto, MJG, Vilalta, RF, Ribera, AF, Roman, AR, Herrero, MTB, Juarez, AR, Lopez, PL, Sanchez, IM, Martinez, JP, Jimenez, MC, Perea, RT, Ruiz-Capillas, JJJ, Pineda, JA
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2019
País:	España
Institución:	Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:	oai:i3pt.fundanetsuite.com:p3031
Acceso en línea:	https://i3pt.portalinvestigacion.com/publicaciones/3031
Access Level:	acceso abierto
Palabra clave:	single nucleotide polymorphisms VDR LTNPs AIDS non-progression

id	ES_d7ecf83c5fb40fa50acecb0dcec2352d
oai_identifier_str	oai:i3pt.fundanetsuite.com:p3031
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
title	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
spellingShingle	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients Jimenez-Sousa, MA single nucleotide polymorphisms VDR LTNPs AIDS non-progression
title_short	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
title_full	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
title_fullStr	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
title_full_unstemmed	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
title_sort	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
dc.creator.none.fl_str_mv	Jimenez-Sousa, MA Jimenez, JL Fernandez-Rodriguez, A Brochado-Kith, O Bellon, JM Bernal-Morell, E Munoz-Fernandez, MA Resino, S del Amo, J Navarro, ML Gonzalez, MI Blanco, JL Gonzalez, J Del Amo, J Jarrin, I Alejos, B Hernando, V Moreno, C Iniesta, C Sousa, LMG Perez, NS Munoz-Fernandez, MA Garcia-Merino, IM Fernandez, IC Rico, CG de la Fuente, JG Concejo, PP Portilla, J Merino, E Reus, S Boix, V Giner, L Gadea, C Portilla, I Pampliega, M Diez, M Rodriguez, JC Sanchez-Paya, J Gomez, JL Hernandez, J Aleman, MR Alonso, MD Hernandez, MI Diaz-Flores, F Garcia, D Pelazas, R Lirola, AL Rubio, R Pulido, F Bisbal, O Hernando, A Dominguez, L Crestelo, DR Bermejo, L Santacreu, M Iribarren, JA Arrizabalaga, J Aramburu, MJ Camino, X Rodriguez-Arrondo, F von Wichmann, MA Tome, LP Goenaga, MA Bustinduy, MJ Azkune, H Ibarguren, M Lizardi, A Kortajarena, X Gutierrez, F Masia, M Padilla, S Navarro, A Montolio, F Robledano, C Colome, JG Adsuar, A Pascual, R Fernandez, M Garcia, E Garcia, JA Barber, X Berenguer, J de Quiros, JCLB Gutierrez, I Ramirez, M Padilla, B Gijon, P Aldamiz-Echevarria, T Tejerina, F Parras, FJ Balsalobre, P Diez, C Latorre, LP Vidal, F Peraire, J Vilades, C Veloso, S Vargas, M Lopez-Dupla, M Olona, M Rull, A Rodriguez-Gallego, E Alba, V Alonso, MM Aldeguer, JL Julia, MB Pitarch, MT Hernandez, IC Munoz, EC Tovar, SC Lleti, MS Navarro, JF Gonzalez-garcia, J Arnalich, F Arribas, JR de la Serna, JIB Castro, JM Escosa, L Herranz, P Hontanon, V Garcia-Bujalance, S Lopez-Hortelano, MG Gonzalez-Baeza, A Martin-Carbonero, ML Mayoral, M Mellado, MJ Mican, RE Montejano, R Montes, ML Moreno, V Perez-Valero, I Rodes, B Sainz, T Sendagorta, E Alcariz, NS Valencia, E Blanco, JR Oteo, JA Ibarra, V Metola, L Sanz, M Perez-Martinez, L Dalmau, D Jaen, A Sanmarti, M Cairo, M Martinez-Lacasa, J Velli, P Font, R Xercavins, M Alonso, N Rivero, M Reparaz, J de Alda, MGR Cano, MTD de Galarreta, BPR Segura, F Amengual, MJ Navarro, G Sala, M Cervantes, M Pineda, V Calzado, S Navarro, M de los Santos, I Sanz, JS Aparicio, AS Cepeda, CS Fraile, LGF Gayo, EM Moreno, S Casado, JL Dronda, F Moreno, A Elias, MJP Ayerbe, CG Gutierrez, C Madrid, N Terron, SD Marti, P Ansa, U Serrano, S Vivancos, MJ Bernal, E Cano, A Garcia, AA Urbieta, JB Munoz, A Alcaraz, MJ Villalba, MD Garcia, F Hernandez, J Pena, A Munoz, L Casas, P Alvarez, M Chueca, N Vinuesa, D Martinez-Montes, C Del Romero, J Rodriguez, C Puerta, T Carrio, JC Vera, M Ballesteros, J Ayerdi, O Riera, M Penaranda, M Leyes, M Ribas, MA Campins, AA Vidal, C Fanjul, F Murillas, J Homar, F Santos, J Ayerbe, CG Viciana, I Palacios, R Gonzalez, CM Viciana, P Espinosa, N Lopez-Cortes, LF Podzamczer, D Ferrer, E Imaz, A Tiraboschi, J Silva, A Saumoy, M Olalla, J del Arco, A de la Torre, J Prada, JL Guerrero, JMGD Stachowski, JP Martinez, OJ Vera, FJ Martinez, L Garcia, J Alcaraz, B Jimeno, A Iglesias, AC Souto, BP de Cea, AM Galera, C Albendin, H Perez, A Iborra, A Moreno, A Merlos, MA Vidal, A Suarez-Garcia, I Malmierca, E Gonzalez-Ruano, P Rodrigo, DM Mohamed-Balghata, MO Vidal, MAG Perez, VE Molina, MJT Garcia, JV Moreno, JPS Gorgolas, M Cabello, A Alvarez, B Prieto, L Moreno, JS Caso, AA Gutierrez, CH Mena, MN Puerto, MJG Vilalta, RF Ribera, AF Roman, AR Herrero, MTB Juarez, AR Lopez, PL Sanchez, IM Martinez, JP Jimenez, MC Perea, RT Ruiz-Capillas, JJJ Pineda, JA
author	Jimenez-Sousa, MA
author_facet	Jimenez-Sousa, MA Jimenez, JL Fernandez-Rodriguez, A Brochado-Kith, O Bellon, JM Bernal-Morell, E Munoz-Fernandez, MA Resino, S del Amo, J Navarro, ML Gonzalez, MI Blanco, JL Gonzalez, J Del Amo, J Jarrin, I Alejos, B Hernando, V Moreno, C Iniesta, C Sousa, LMG Perez, NS Garcia-Merino, IM Fernandez, IC Rico, CG de la Fuente, JG Concejo, PP Portilla, J Merino, E Reus, S Boix, V Giner, L Gadea, C Portilla, I Pampliega, M Diez, M Rodriguez, JC Sanchez-Paya, J Gomez, JL Hernandez, J Aleman, MR Alonso, MD Hernandez, MI Diaz-Flores, F Garcia, D Pelazas, R Lirola, AL Rubio, R Pulido, F Bisbal, O Hernando, A Dominguez, L Crestelo, DR Bermejo, L Santacreu, M Iribarren, JA Arrizabalaga, J Aramburu, MJ Camino, X Rodriguez-Arrondo, F von Wichmann, MA Tome, LP Goenaga, MA Bustinduy, MJ Azkune, H Ibarguren, M Lizardi, A Kortajarena, X Gutierrez, F Masia, M Padilla, S Navarro, A Montolio, F Robledano, C Colome, JG Adsuar, A Pascual, R Fernandez, M Garcia, E Garcia, JA Barber, X Berenguer, J de Quiros, JCLB Gutierrez, I Ramirez, M Padilla, B Gijon, P Aldamiz-Echevarria, T Tejerina, F Parras, FJ Balsalobre, P Diez, C Latorre, LP Vidal, F Peraire, J Vilades, C Veloso, S Vargas, M Lopez-Dupla, M Olona, M Rull, A Rodriguez-Gallego, E Alba, V Alonso, MM Aldeguer, JL Julia, MB Pitarch, MT Hernandez, IC Munoz, EC Tovar, SC Lleti, MS Navarro, JF Gonzalez-garcia, J Arnalich, F Arribas, JR de la Serna, JIB Castro, JM Escosa, L Herranz, P Hontanon, V Garcia-Bujalance, S Lopez-Hortelano, MG Gonzalez-Baeza, A Martin-Carbonero, ML Mayoral, M Mellado, MJ Mican, RE Montejano, R Montes, ML Moreno, V Perez-Valero, I Rodes, B Sainz, T Sendagorta, E Alcariz, NS Valencia, E Blanco, JR Oteo, JA Ibarra, V Metola, L Sanz, M Perez-Martinez, L Dalmau, D Jaen, A Sanmarti, M Cairo, M Martinez-Lacasa, J Velli, P Font, R Xercavins, M Alonso, N Rivero, M Reparaz, J de Alda, MGR Cano, MTD de Galarreta, BPR Segura, F Amengual, MJ Navarro, G Sala, M Cervantes, M Pineda, V Calzado, S Navarro, M de los Santos, I Sanz, JS Aparicio, AS Cepeda, CS Fraile, LGF Gayo, EM Moreno, S Casado, JL Dronda, F Moreno, A Elias, MJP Ayerbe, CG Gutierrez, C Madrid, N Terron, SD Marti, P Ansa, U Serrano, S Vivancos, MJ Bernal, E Cano, A Garcia, AA Urbieta, JB Munoz, A Alcaraz, MJ Villalba, MD Garcia, F Pena, A Munoz, L Casas, P Alvarez, M Chueca, N Vinuesa, D Martinez-Montes, C Del Romero, J Rodriguez, C Puerta, T Carrio, JC Vera, M Ballesteros, J Ayerdi, O Riera, M Penaranda, M Leyes, M Ribas, MA Campins, AA Vidal, C Fanjul, F Murillas, J Homar, F Santos, J Viciana, I Palacios, R Gonzalez, CM Viciana, P Espinosa, N Lopez-Cortes, LF Podzamczer, D Ferrer, E Imaz, A Tiraboschi, J Silva, A Saumoy, M Olalla, J del Arco, A de la Torre, J Prada, JL Guerrero, JMGD Stachowski, JP Martinez, OJ Vera, FJ Martinez, L Garcia, J Alcaraz, B Jimeno, A Iglesias, AC Souto, BP de Cea, AM Galera, C Albendin, H Perez, A Iborra, A Merlos, MA Vidal, A Suarez-Garcia, I Malmierca, E Gonzalez-Ruano, P Rodrigo, DM Mohamed-Balghata, MO Vidal, MAG Perez, VE Molina, MJT Garcia, JV Moreno, JPS Gorgolas, M Cabello, A Alvarez, B Prieto, L Moreno, JS Caso, AA Gutierrez, CH Mena, MN Puerto, MJG Vilalta, RF Ribera, AF Roman, AR Herrero, MTB Juarez, AR Lopez, PL Sanchez, IM Martinez, JP Jimenez, MC Perea, RT Ruiz-Capillas, JJJ Pineda, JA
author_role	author
author2	Jimenez, JL Fernandez-Rodriguez, A Brochado-Kith, O Bellon, JM Bernal-Morell, E Munoz-Fernandez, MA Resino, S del Amo, J Navarro, ML Gonzalez, MI Blanco, JL Gonzalez, J Del Amo, J Jarrin, I Alejos, B Hernando, V Moreno, C Iniesta, C Sousa, LMG Perez, NS Garcia-Merino, IM Fernandez, IC Rico, CG de la Fuente, JG Concejo, PP Portilla, J Merino, E Reus, S Boix, V Giner, L Gadea, C Portilla, I Pampliega, M Diez, M Rodriguez, JC Sanchez-Paya, J Gomez, JL Hernandez, J Aleman, MR Alonso, MD Hernandez, MI Diaz-Flores, F Garcia, D Pelazas, R Lirola, AL Rubio, R Pulido, F Bisbal, O Hernando, A Dominguez, L Crestelo, DR Bermejo, L Santacreu, M Iribarren, JA Arrizabalaga, J Aramburu, MJ Camino, X Rodriguez-Arrondo, F von Wichmann, MA Tome, LP Goenaga, MA Bustinduy, MJ Azkune, H Ibarguren, M Lizardi, A Kortajarena, X Gutierrez, F Masia, M Padilla, S Navarro, A Montolio, F Robledano, C Colome, JG Adsuar, A Pascual, R Fernandez, M Garcia, E Garcia, JA Barber, X Berenguer, J de Quiros, JCLB Gutierrez, I Ramirez, M Padilla, B Gijon, P Aldamiz-Echevarria, T Tejerina, F Parras, FJ Balsalobre, P Diez, C Latorre, LP Vidal, F Peraire, J Vilades, C Veloso, S Vargas, M Lopez-Dupla, M Olona, M Rull, A Rodriguez-Gallego, E Alba, V Alonso, MM Aldeguer, JL Julia, MB Pitarch, MT Hernandez, IC Munoz, EC Tovar, SC Lleti, MS Navarro, JF Gonzalez-garcia, J Arnalich, F Arribas, JR de la Serna, JIB Castro, JM Escosa, L Herranz, P Hontanon, V Garcia-Bujalance, S Lopez-Hortelano, MG Gonzalez-Baeza, A Martin-Carbonero, ML Mayoral, M Mellado, MJ Mican, RE Montejano, R Montes, ML Moreno, V Perez-Valero, I Rodes, B Sainz, T Sendagorta, E Alcariz, NS Valencia, E Blanco, JR Oteo, JA Ibarra, V Metola, L Sanz, M Perez-Martinez, L Dalmau, D Jaen, A Sanmarti, M Cairo, M Martinez-Lacasa, J Velli, P Font, R Xercavins, M Alonso, N Rivero, M Reparaz, J de Alda, MGR Cano, MTD de Galarreta, BPR Segura, F Amengual, MJ Navarro, G Sala, M Cervantes, M Pineda, V Calzado, S Navarro, M de los Santos, I Sanz, JS Aparicio, AS Cepeda, CS Fraile, LGF Gayo, EM Moreno, S Casado, JL Dronda, F Moreno, A Elias, MJP Ayerbe, CG Gutierrez, C Madrid, N Terron, SD Marti, P Ansa, U Serrano, S Vivancos, MJ Bernal, E Cano, A Garcia, AA Urbieta, JB Munoz, A Alcaraz, MJ Villalba, MD Garcia, F Pena, A Munoz, L Casas, P Alvarez, M Chueca, N Vinuesa, D Martinez-Montes, C Del Romero, J Rodriguez, C Puerta, T Carrio, JC Vera, M Ballesteros, J Ayerdi, O Riera, M Penaranda, M Leyes, M Ribas, MA Campins, AA Vidal, C Fanjul, F Murillas, J Homar, F Santos, J Viciana, I Palacios, R Gonzalez, CM Viciana, P Espinosa, N Lopez-Cortes, LF Podzamczer, D Ferrer, E Imaz, A Tiraboschi, J Silva, A Saumoy, M Olalla, J del Arco, A de la Torre, J Prada, JL Guerrero, JMGD Stachowski, JP Martinez, OJ Vera, FJ Martinez, L Garcia, J Alcaraz, B Jimeno, A Iglesias, AC Souto, BP de Cea, AM Galera, C Albendin, H Perez, A Iborra, A Merlos, MA Vidal, A Suarez-Garcia, I Malmierca, E Gonzalez-Ruano, P Rodrigo, DM Mohamed-Balghata, MO Vidal, MAG Perez, VE Molina, MJT Garcia, JV Moreno, JPS Gorgolas, M Cabello, A Alvarez, B Prieto, L Moreno, JS Caso, AA Gutierrez, CH Mena, MN Puerto, MJG Vilalta, RF Ribera, AF Roman, AR Herrero, MTB Juarez, AR Lopez, PL Sanchez, IM Martinez, JP Jimenez, MC Perea, RT Ruiz-Capillas, JJJ Pineda, JA
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	single nucleotide polymorphisms VDR LTNPs AIDS non-progression
topic	single nucleotide polymorphisms VDR LTNPs AIDS non-progression
description	Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naive HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience's MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naive HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes.
publishDate	2019
dc.date.none.fl_str_mv	2019
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://i3pt.portalinvestigacion.com/publicaciones/3031
url	https://i3pt.portalinvestigacion.com/publicaciones/3031
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Journal of Clinical Medicine ISSN: 20770383 reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str	Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869421052070723584
spelling	VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected PatientsJimenez-Sousa, MAJimenez, JLFernandez-Rodriguez, ABrochado-Kith, OBellon, JMBernal-Morell, EMunoz-Fernandez, MAResino, Sdel Amo, JNavarro, MLGonzalez, MIBlanco, JLGonzalez, JDel Amo, JJarrin, IAlejos, BHernando, VMoreno, CIniesta, CSousa, LMGPerez, NSMunoz-Fernandez, MAGarcia-Merino, IMFernandez, ICRico, CGde la Fuente, JGConcejo, PPPortilla, JMerino, EReus, SBoix, VGiner, LGadea, CPortilla, IPampliega, MDiez, MRodriguez, JCSanchez-Paya, JGomez, JLHernandez, JAleman, MRAlonso, MDHernandez, MIDiaz-Flores, FGarcia, DPelazas, RLirola, ALRubio, RPulido, FBisbal, OHernando, ADominguez, LCrestelo, DRBermejo, LSantacreu, MIribarren, JAArrizabalaga, JAramburu, MJCamino, XRodriguez-Arrondo, Fvon Wichmann, MATome, LPGoenaga, MABustinduy, MJAzkune, HIbarguren, MLizardi, AKortajarena, XGutierrez, FMasia, MPadilla, SNavarro, AMontolio, FRobledano, CColome, JGAdsuar, APascual, RFernandez, MGarcia, EGarcia, JABarber, XBerenguer, Jde Quiros, JCLBGutierrez, IRamirez, MPadilla, BGijon, PAldamiz-Echevarria, TTejerina, FParras, FJBalsalobre, PDiez, CLatorre, LPVidal, FPeraire, JVilades, CVeloso, SVargas, MLopez-Dupla, MOlona, MRull, ARodriguez-Gallego, EAlba, VAlonso, MMAldeguer, JLJulia, MBPitarch, MTHernandez, ICMunoz, ECTovar, SCLleti, MSNavarro, JFGonzalez-garcia, JArnalich, FArribas, JRde la Serna, JIBCastro, JMEscosa, LHerranz, PHontanon, VGarcia-Bujalance, SLopez-Hortelano, MGGonzalez-Baeza, AMartin-Carbonero, MLMayoral, MMellado, MJMican, REMontejano, RMontes, MLMoreno, VPerez-Valero, IRodes, BSainz, TSendagorta, EAlcariz, NSValencia, EBlanco, JROteo, JAIbarra, VMetola, LSanz, MPerez-Martinez, LDalmau, DJaen, ASanmarti, MCairo, MMartinez-Lacasa, JVelli, PFont, RXercavins, MAlonso, NRivero, MReparaz, Jde Alda, MGRCano, MTDde Galarreta, BPRSegura, FAmengual, MJNavarro, GSala, MCervantes, MPineda, VCalzado, SNavarro, Mde los Santos, ISanz, JSAparicio, ASCepeda, CSFraile, LGFGayo, EMMoreno, SCasado, JLDronda, FMoreno, AElias, MJPAyerbe, CGGutierrez, CMadrid, NTerron, SDMarti, PAnsa, USerrano, SVivancos, MJBernal, ECano, AGarcia, AAUrbieta, JBMunoz, AAlcaraz, MJVillalba, MDGarcia, FHernandez, JPena, AMunoz, LCasas, PAlvarez, MChueca, NVinuesa, DMartinez-Montes, CDel Romero, JRodriguez, CPuerta, TCarrio, JCVera, MBallesteros, JAyerdi, ORiera, MPenaranda, MLeyes, MRibas, MACampins, AAVidal, CFanjul, FMurillas, JHomar, FSantos, JAyerbe, CGViciana, IPalacios, RGonzalez, CMViciana, PEspinosa, NLopez-Cortes, LFPodzamczer, DFerrer, EImaz, ATiraboschi, JSilva, ASaumoy, MOlalla, Jdel Arco, Ade la Torre, JPrada, JLGuerrero, JMGDStachowski, JPMartinez, OJVera, FJMartinez, LGarcia, JAlcaraz, BJimeno, AIglesias, ACSouto, BPde Cea, AMGalera, CAlbendin, HPerez, AIborra, AMoreno, AMerlos, MAVidal, ASuarez-Garcia, IMalmierca, EGonzalez-Ruano, PRodrigo, DMMohamed-Balghata, MOVidal, MAGPerez, VEMolina, MJTGarcia, JVMoreno, JPSGorgolas, MCabello, AAlvarez, BPrieto, LMoreno, JSCaso, AAGutierrez, CHMena, MNPuerto, MJGVilalta, RFRibera, AFRoman, ARHerrero, MTBJuarez, ARLopez, PLSanchez, IMMartinez, JPJimenez, MCPerea, RTRuiz-Capillas, JJJPineda, JAsingle nucleotide polymorphismsVDRLTNPsAIDSnon-progressionBackground: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naive HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience's MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naive HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/3031Journal of Clinical MedicineISSN: 20770383reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p30312026-06-21T15:30:37Z
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VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients

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