Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study

Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents. Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17...

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Authors: Agostinis-Sobrinho, C., Gómez-Martínez, S., Nova, E., Hernandez, A., Labayen, I., Kafatos, A., Gottand, F., Molnár, D., Ferrari, M., Moreno, L.A., González-Gross, M., Michels, N., Ruperez, A., Ruiz, J.R., Marcos, A.
Format: article
Status:Versión aceptada para publicación
Publication Date:2018
Country:España
Institution:Universidad de Zaragoza
Repository:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:86196
Online Access:http://zaguan.unizar.es/record/86196
Access Level:Open access
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repository_id_str
spelling Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA studyAgostinis-Sobrinho, C.Gómez-Martínez, S.Nova, E.Hernandez, A.Labayen, I.Kafatos, A.Gottand, F.Molnár, D.Ferrari, M.Moreno, L.A.González-Gross, M.Michels, N.Ruperez, A.Ruiz, J.R.Marcos, A.Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents. Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors, and sleep duration. We also measured endocrine, metabolic, and immunological biomarkers. Results: Three-cluster solutions were identified: (a) light-PA time, moderate-vigorous-PA time and sedentary time, (b) light-PA time, moderate-vigorous-PA time, sedentary time and sleep time, (c) light-PA time, moderate-vigorous-PA time, sedentary time and body composition. In addition, each cluster solution was defined as: “healthy, ” “medium healthy, ” and “unhealthy” according to the presented rating. Analysis of variance showed that overall the healthiest groups from the three clusters analyzed presented a better metabolic profile. A decision tree analysis showed that leptin had a strong association with cluster 3 in both boys and girls, high-density lipoprotein cholesterol had the strongest association with clusters 1 and 3 in boys. Cortisol had the strongest association with cluster 1. HOMA index (homeostatic model assessment) and C3 showed a strong association with cluster 3 in girls. Conclusions: Our results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness, and sleep, with some gender-specific findings. These results highlight the importance to consider multiple lifestyle-related health factors in the assessment of adolescents'' health to plan favorable strategies.2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://zaguan.unizar.es/record/86196reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/EUR/FP6/FOODCT-2005-007034info:eu-repo/semantics/openAccessoai:zaguan.unizar.es:861962026-05-29T13:59:51Z
dc.title.none.fl_str_mv Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study
title Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study
spellingShingle Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study
Agostinis-Sobrinho, C.
title_short Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study
title_full Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study
title_fullStr Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study
title_full_unstemmed Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study
title_sort Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study
dc.creator.none.fl_str_mv Agostinis-Sobrinho, C.
Gómez-Martínez, S.
Nova, E.
Hernandez, A.
Labayen, I.
Kafatos, A.
Gottand, F.
Molnár, D.
Ferrari, M.
Moreno, L.A.
González-Gross, M.
Michels, N.
Ruperez, A.
Ruiz, J.R.
Marcos, A.
author Agostinis-Sobrinho, C.
author_facet Agostinis-Sobrinho, C.
Gómez-Martínez, S.
Nova, E.
Hernandez, A.
Labayen, I.
Kafatos, A.
Gottand, F.
Molnár, D.
Ferrari, M.
Moreno, L.A.
González-Gross, M.
Michels, N.
Ruperez, A.
Ruiz, J.R.
Marcos, A.
author_role author
author2 Gómez-Martínez, S.
Nova, E.
Hernandez, A.
Labayen, I.
Kafatos, A.
Gottand, F.
Molnár, D.
Ferrari, M.
Moreno, L.A.
González-Gross, M.
Michels, N.
Ruperez, A.
Ruiz, J.R.
Marcos, A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
description Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents. Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors, and sleep duration. We also measured endocrine, metabolic, and immunological biomarkers. Results: Three-cluster solutions were identified: (a) light-PA time, moderate-vigorous-PA time and sedentary time, (b) light-PA time, moderate-vigorous-PA time, sedentary time and sleep time, (c) light-PA time, moderate-vigorous-PA time, sedentary time and body composition. In addition, each cluster solution was defined as: “healthy, ” “medium healthy, ” and “unhealthy” according to the presented rating. Analysis of variance showed that overall the healthiest groups from the three clusters analyzed presented a better metabolic profile. A decision tree analysis showed that leptin had a strong association with cluster 3 in both boys and girls, high-density lipoprotein cholesterol had the strongest association with clusters 1 and 3 in boys. Cortisol had the strongest association with cluster 1. HOMA index (homeostatic model assessment) and C3 showed a strong association with cluster 3 in girls. Conclusions: Our results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness, and sleep, with some gender-specific findings. These results highlight the importance to consider multiple lifestyle-related health factors in the assessment of adolescents'' health to plan favorable strategies.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/86196
url http://zaguan.unizar.es/record/86196
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/EUR/FP6/FOODCT-2005-007034
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
repository.name.fl_str_mv
repository.mail.fl_str_mv
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