Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats

In preterm newborns the immaturity of the immune system is remarkable, with reduced innate and adaptive immune responses. Many bioactive compounds in breast milk, such as growth factors and adipokines, contribute to the immune system's maturation in early life. However, studies on the immunoreg...

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Autores: Grases Pintó, Blanca, Torres-Castro, Paulina, Marín-Morote, Lídia, Abril Gil, Maria del Mar, Castell, Margarida, Rodríguez Lagunas, María José, Pérez-Cano, Francisco J., Franch i Masferrer, Àngels
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/156558
Acceso en línea:https://hdl.handle.net/2445/156558
Access Level:acceso abierto
Palabra clave:Infants prematurs
Sistema immunitari
Llet materna
Leptina
Premature infants
Immune system
Breast milk
Leptin
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spelling Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling RatsGrases Pintó, BlancaTorres-Castro, PaulinaMarín-Morote, LídiaAbril Gil, Maria del MarCastell, MargaridaRodríguez Lagunas, María JoséPérez-Cano, Francisco J.Franch i Masferrer, ÀngelsInfants prematursSistema immunitariLlet maternaLeptinaPremature infantsImmune systemBreast milkLeptinIn preterm newborns the immaturity of the immune system is remarkable, with reduced innate and adaptive immune responses. Many bioactive compounds in breast milk, such as growth factors and adipokines, contribute to the immune system's maturation in early life. However, studies on the immunoregulatory activity in preterm neonates are practically nonexistent. The aim of the present study was to determine whether a nutritional supplementation in early life with leptin or epidermal growth factor (EGF) was able to promote the maturation of the systemic and intestinal immune system in preterm conditions. For this purpose, premature rats were daily supplemented by oral gavage with leptin or EGF. Term and Preterm groups receiving vehicle were used as controls. Preterm rats showed deficiencies compared to full-term ones, such as lower body weights, erythrocyte counts, plasma IgG and IgM concentrations and B cell percentages, and higher values of Th and Tc TCRαβ+ cells in mesenteric lymph nodes, and intestinal permeability, among others. However, leptin and EGF supplementation were able to revert some of these deficiencies and to improve the premature immune system's development. These results suggest that leptin and EGF are involved in enhancing the maturation of the systemic and intestinal immune system in preterm conditions.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/156558Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu11102380Nutrients, 2019, vol. 11, num. 10, p. 2380https://doi.org/10.3390/nu11102380cc-by (c) Grases Pintó, Blanca et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1565582026-05-27T06:46:51Z
dc.title.none.fl_str_mv Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
title Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
spellingShingle Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
Grases Pintó, Blanca
Infants prematurs
Sistema immunitari
Llet materna
Leptina
Premature infants
Immune system
Breast milk
Leptin
title_short Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
title_full Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
title_fullStr Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
title_full_unstemmed Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
title_sort Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
dc.creator.none.fl_str_mv Grases Pintó, Blanca
Torres-Castro, Paulina
Marín-Morote, Lídia
Abril Gil, Maria del Mar
Castell, Margarida
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
author Grases Pintó, Blanca
author_facet Grases Pintó, Blanca
Torres-Castro, Paulina
Marín-Morote, Lídia
Abril Gil, Maria del Mar
Castell, Margarida
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
author_role author
author2 Torres-Castro, Paulina
Marín-Morote, Lídia
Abril Gil, Maria del Mar
Castell, Margarida
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infants prematurs
Sistema immunitari
Llet materna
Leptina
Premature infants
Immune system
Breast milk
Leptin
topic Infants prematurs
Sistema immunitari
Llet materna
Leptina
Premature infants
Immune system
Breast milk
Leptin
description In preterm newborns the immaturity of the immune system is remarkable, with reduced innate and adaptive immune responses. Many bioactive compounds in breast milk, such as growth factors and adipokines, contribute to the immune system's maturation in early life. However, studies on the immunoregulatory activity in preterm neonates are practically nonexistent. The aim of the present study was to determine whether a nutritional supplementation in early life with leptin or epidermal growth factor (EGF) was able to promote the maturation of the systemic and intestinal immune system in preterm conditions. For this purpose, premature rats were daily supplemented by oral gavage with leptin or EGF. Term and Preterm groups receiving vehicle were used as controls. Preterm rats showed deficiencies compared to full-term ones, such as lower body weights, erythrocyte counts, plasma IgG and IgM concentrations and B cell percentages, and higher values of Th and Tc TCRαβ+ cells in mesenteric lymph nodes, and intestinal permeability, among others. However, leptin and EGF supplementation were able to revert some of these deficiencies and to improve the premature immune system's development. These results suggest that leptin and EGF are involved in enhancing the maturation of the systemic and intestinal immune system in preterm conditions.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/156558
url https://hdl.handle.net/2445/156558
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu11102380
Nutrients, 2019, vol. 11, num. 10, p. 2380
https://doi.org/10.3390/nu11102380
dc.rights.none.fl_str_mv cc-by (c) Grases Pintó, Blanca et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Grases Pintó, Blanca et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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