A Novel Quantum Dot-Based pH Probe for Long-Term Fluorescence Lifetime Imaging Microscopy Experiments in Living Cells

The use of two nanoparticles for quantitative pH measurements in live cells by means of fluorescence lifetime imaging microscopy (FLIM) is investigated here. These results show the promising applications of this nanoprobe to monitor the intracellular pH and cell state employing the FLIM technique.

Detalles Bibliográficos
Autores: Herrera Ochoa, Diego, Pacheco Liñán, Pedro J., Bravo Pérez, Iván, Garzón Ruiz, Andrés
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/36854
Acceso en línea:https://hdl.handle.net/10578/36854
Access Level:acceso abierto
Palabra clave:Fluorescence lifetime probe
Intracellular pH quantification
Histidine-based nanoparticle
Quantum dot
Descripción
Sumario:The use of two nanoparticles for quantitative pH measurements in live cells by means of fluorescence lifetime imaging microscopy (FLIM) is investigated here. These results show the promising applications of this nanoprobe to monitor the intracellular pH and cell state employing the FLIM technique.