Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 4...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/175091 |
| Acceso en línea: | https://hdl.handle.net/2445/175091 |
| Access Level: | acceso abierto |
| Palabra clave: | Consum d'alcohol Càncer d'estómac Drinking of alcoholic beverages Stomach cancer |
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Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studiesJayasekara, HarindraMacInnis, Robert J.Luján Barroso, LeilaMayen Chacon, Ana LuciaCross, Amanda J.Wallner, BengtPalli, DomenicoRicceri, FulvioPala, ValeriaPanico, SalvatoreTumino, RosarioKühn, TilmanKaaks, RudolfTsilidis, KostasSánchez, María JoséAmiano, PilarArdanaz, EvaChirlaque, María DoloresMerino, SusanaRothwell, Joseph A.Boutron-Ruault, Marie-ChristineSeveri, GianlucaSternby, HannaSonestedt, EmilyBueno de Mesquita, H. BasBoeing, HeinerTravis, RuthSandanger, Torkjel M.Trichopoulou, AntoniaKarakatsani, AnnaPeppa, EleniTjønneland, AnneYang, YiHodge, Allison M.Mitchell, HazelHaydon, AndrewRoom, RobinHopper, John L.Weiderpass, ElisabeteGunter, Marc J.Riboli, ElioGiles, Graham G.Milne, Roger L.Agudo, AntonioEnglish, Dallas R.Ferrari, PietroConsum d'alcoholCàncer d'estómacDrinking of alcoholic beveragesStomach cancerAlcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.John Wiley & Sons Ltd.2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/175091Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/ijc.33504International Journal of Cancer, 2021https://doi.org/10.1002/ijc.33504cc by (c) Jayasekara et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1750912026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies |
| title |
Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies |
| spellingShingle |
Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies Jayasekara, Harindra Consum d'alcohol Càncer d'estómac Drinking of alcoholic beverages Stomach cancer |
| title_short |
Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies |
| title_full |
Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies |
| title_fullStr |
Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies |
| title_full_unstemmed |
Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies |
| title_sort |
Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies |
| dc.creator.none.fl_str_mv |
Jayasekara, Harindra MacInnis, Robert J. Luján Barroso, Leila Mayen Chacon, Ana Lucia Cross, Amanda J. Wallner, Bengt Palli, Domenico Ricceri, Fulvio Pala, Valeria Panico, Salvatore Tumino, Rosario Kühn, Tilman Kaaks, Rudolf Tsilidis, Kostas Sánchez, María José Amiano, Pilar Ardanaz, Eva Chirlaque, María Dolores Merino, Susana Rothwell, Joseph A. Boutron-Ruault, Marie-Christine Severi, Gianluca Sternby, Hanna Sonestedt, Emily Bueno de Mesquita, H. Bas Boeing, Heiner Travis, Ruth Sandanger, Torkjel M. Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Tjønneland, Anne Yang, Yi Hodge, Allison M. Mitchell, Hazel Haydon, Andrew Room, Robin Hopper, John L. Weiderpass, Elisabete Gunter, Marc J. Riboli, Elio Giles, Graham G. Milne, Roger L. Agudo, Antonio English, Dallas R. Ferrari, Pietro |
| author |
Jayasekara, Harindra |
| author_facet |
Jayasekara, Harindra MacInnis, Robert J. Luján Barroso, Leila Mayen Chacon, Ana Lucia Cross, Amanda J. Wallner, Bengt Palli, Domenico Ricceri, Fulvio Pala, Valeria Panico, Salvatore Tumino, Rosario Kühn, Tilman Kaaks, Rudolf Tsilidis, Kostas Sánchez, María José Amiano, Pilar Ardanaz, Eva Chirlaque, María Dolores Merino, Susana Rothwell, Joseph A. Boutron-Ruault, Marie-Christine Severi, Gianluca Sternby, Hanna Sonestedt, Emily Bueno de Mesquita, H. Bas Boeing, Heiner Travis, Ruth Sandanger, Torkjel M. Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Tjønneland, Anne Yang, Yi Hodge, Allison M. Mitchell, Hazel Haydon, Andrew Room, Robin Hopper, John L. Weiderpass, Elisabete Gunter, Marc J. Riboli, Elio Giles, Graham G. Milne, Roger L. Agudo, Antonio English, Dallas R. Ferrari, Pietro |
| author_role |
author |
| author2 |
MacInnis, Robert J. Luján Barroso, Leila Mayen Chacon, Ana Lucia Cross, Amanda J. Wallner, Bengt Palli, Domenico Ricceri, Fulvio Pala, Valeria Panico, Salvatore Tumino, Rosario Kühn, Tilman Kaaks, Rudolf Tsilidis, Kostas Sánchez, María José Amiano, Pilar Ardanaz, Eva Chirlaque, María Dolores Merino, Susana Rothwell, Joseph A. Boutron-Ruault, Marie-Christine Severi, Gianluca Sternby, Hanna Sonestedt, Emily Bueno de Mesquita, H. Bas Boeing, Heiner Travis, Ruth Sandanger, Torkjel M. Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Tjønneland, Anne Yang, Yi Hodge, Allison M. Mitchell, Hazel Haydon, Andrew Room, Robin Hopper, John L. Weiderpass, Elisabete Gunter, Marc J. Riboli, Elio Giles, Graham G. Milne, Roger L. Agudo, Antonio English, Dallas R. Ferrari, Pietro |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Consum d'alcohol Càncer d'estómac Drinking of alcoholic beverages Stomach cancer |
| topic |
Consum d'alcohol Càncer d'estómac Drinking of alcoholic beverages Stomach cancer |
| description |
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/175091 |
| url |
https://hdl.handle.net/2445/175091 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1002/ijc.33504 International Journal of Cancer, 2021 https://doi.org/10.1002/ijc.33504 |
| dc.rights.none.fl_str_mv |
cc by (c) Jayasekara et al., 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc by (c) Jayasekara et al., 2021 http://creativecommons.org/licenses/by/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
15 p. application/pdf |
| dc.publisher.none.fl_str_mv |
John Wiley & Sons Ltd. |
| publisher.none.fl_str_mv |
John Wiley & Sons Ltd. |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869421028122296320 |
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15,81155 |