From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish

Glyphosate, a globally prevalent herbicide known for its selective inhibition of the shikimate pathway in plants, is now implicated in physiological effects on humans and animals, probably due to its impacts in their gut microbiomes which possess the shikimate pathway. In this study, we investigate...

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Autores: Bellot, Marina, Carrillo, Maria Paula, Bedrossiantz, Juliette, Zheng, Jiamin, Mandal, Rupasri, Wishart, David S., Gómez-Canela, Cristian, Vila-Costa, Maria, Prats, Eva, Piña, Benjamí, Raldúa, Demetrio
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/4404
Acceso en línea:http://hdl.handle.net/20.500.14342/4404
https://doi.org/10.1016/j.ecoenv.2023.115888
Access Level:acceso abierto
Palabra clave:Neurotoxicity
transgenics
Herbicides
Microbiota
Neurotransmitter
504
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spelling From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafishBellot, MarinaCarrillo, Maria PaulaBedrossiantz, JulietteZheng, JiaminMandal, RupasriWishart, David S.Gómez-Canela, CristianVila-Costa, MariaPrats, EvaPiña, BenjamíRaldúa, DemetrioNeurotoxicitytransgenicsHerbicidesMicrobiotaNeurotransmitter504Glyphosate, a globally prevalent herbicide known for its selective inhibition of the shikimate pathway in plants, is now implicated in physiological effects on humans and animals, probably due to its impacts in their gut microbiomes which possess the shikimate pathway. In this study, we investigate the effects of environmentally relevant concentrations of glyphosate on the gut microbiota, neurotransmitter levels, and anxiety in zebrafish. Our findings demonstrate that glyphosate exposure leads to dysbiosis in the zebrafish gut, alterations in central and peripheral serotonin levels, increased dopamine levels in the brain, and notable changes in anxiety and social behavior. While the dysbiosis can be attributed to glyphosate’s antimicrobial properties, the observed effects on neurotransmitter levels leading to the reported induction of oxidative stress in the brain indicate a novel and significant mode of action for glyphosate, namely the impairment of the microbiome-gut-axis. While further investigations are necessary to determine the relevance of this mechanism in humans, our findings shed light on the potential explanation for the contradictory reports on the safety of glyphosate for consumers.info:eu-repo/semantics/publishedVersionElsevier Inc.Universitat Ramon Llull. IQS2023info:eu-repo/semantics/article8p.http://hdl.handle.net/20.500.14342/4404https://doi.org/10.1016/j.ecoenv.2023.115888reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEcotoxicology and Environmental SafetyAttribution 4.0 International© L'autor/ahttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/44042026-05-29T05:05:01Z
dc.title.none.fl_str_mv From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
title From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
spellingShingle From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
Bellot, Marina
Neurotoxicity
transgenics
Herbicides
Microbiota
Neurotransmitter
504
title_short From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
title_full From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
title_fullStr From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
title_full_unstemmed From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
title_sort From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
dc.creator.none.fl_str_mv Bellot, Marina
Carrillo, Maria Paula
Bedrossiantz, Juliette
Zheng, Jiamin
Mandal, Rupasri
Wishart, David S.
Gómez-Canela, Cristian
Vila-Costa, Maria
Prats, Eva
Piña, Benjamí
Raldúa, Demetrio
author Bellot, Marina
author_facet Bellot, Marina
Carrillo, Maria Paula
Bedrossiantz, Juliette
Zheng, Jiamin
Mandal, Rupasri
Wishart, David S.
Gómez-Canela, Cristian
Vila-Costa, Maria
Prats, Eva
Piña, Benjamí
Raldúa, Demetrio
author_role author
author2 Carrillo, Maria Paula
Bedrossiantz, Juliette
Zheng, Jiamin
Mandal, Rupasri
Wishart, David S.
Gómez-Canela, Cristian
Vila-Costa, Maria
Prats, Eva
Piña, Benjamí
Raldúa, Demetrio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Neurotoxicity
transgenics
Herbicides
Microbiota
Neurotransmitter
504
topic Neurotoxicity
transgenics
Herbicides
Microbiota
Neurotransmitter
504
description Glyphosate, a globally prevalent herbicide known for its selective inhibition of the shikimate pathway in plants, is now implicated in physiological effects on humans and animals, probably due to its impacts in their gut microbiomes which possess the shikimate pathway. In this study, we investigate the effects of environmentally relevant concentrations of glyphosate on the gut microbiota, neurotransmitter levels, and anxiety in zebrafish. Our findings demonstrate that glyphosate exposure leads to dysbiosis in the zebrafish gut, alterations in central and peripheral serotonin levels, increased dopamine levels in the brain, and notable changes in anxiety and social behavior. While the dysbiosis can be attributed to glyphosate’s antimicrobial properties, the observed effects on neurotransmitter levels leading to the reported induction of oxidative stress in the brain indicate a novel and significant mode of action for glyphosate, namely the impairment of the microbiome-gut-axis. While further investigations are necessary to determine the relevance of this mechanism in humans, our findings shed light on the potential explanation for the contradictory reports on the safety of glyphosate for consumers.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/4404
https://doi.org/10.1016/j.ecoenv.2023.115888
url http://hdl.handle.net/20.500.14342/4404
https://doi.org/10.1016/j.ecoenv.2023.115888
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Ecotoxicology and Environmental Safety
dc.rights.none.fl_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8p.
dc.publisher.none.fl_str_mv Elsevier Inc.
publisher.none.fl_str_mv Elsevier Inc.
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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