NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches

Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 wit...

ver descrição completa

Detalhes bibliográficos
Autores: Almodóvar Payá, Carmen, Guardiola Ripoll, Maria, Giralt López, Maria, Gallego, Carme, Salgado Pineda, Pilar, Miret, Salvador, Salvador, Raymond, Muñoz, María J., Lázaro, Luisa, Guerrero Pedraza, Amalia, Parellada, Mara, Carrión, María I., Cuesta, Manuel J., Maristany, Teresa, Sarró, Salvador, Fañanás Saura, Lourdes, Callado, Luis F., Arias, Bárbara, Pomarol-Clotet, Edith, Fatjó-Vilas, Mar
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/83669
Acesso em linha:https://doi.org/10.3390/ijms23137456
http://hdl.handle.net/10459.1/83669
Access Level:acceso abierto
Palavra-chave:NRN1
Age at onset
Functional magnetic resonance imaging (fMRI)
Schizophrenia-spectrum disorders
Working memory
id ES_d7a385ac1c4feea93edc26c3dacabc97
oai_identifier_str oai:recercat.cat:10459.1/83669
network_acronym_str ES
network_name_str España
repository_id_str
spelling NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging ApproachesAlmodóvar Payá, CarmenGuardiola Ripoll, MariaGiralt López, MariaGallego, CarmeSalgado Pineda, PilarMiret, SalvadorSalvador, RaymondMuñoz, María J.Lázaro, LuisaGuerrero Pedraza, AmaliaParellada, MaraCarrión, María I.Cuesta, Manuel J.Maristany, TeresaSarró, SalvadorFañanás Saura, LourdesCallado, Luis F.Arias, BárbaraPomarol-Clotet, EdithFatjó-Vilas, MarNRN1Age at onsetFunctional magnetic resonance imaging (fMRI)Schizophrenia-spectrum disordersWorking memoryIncluded in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic association analyses using a family-based sample (80 early-onset (EO) trios (offspring onset ≤ 18 years) and 71 adult-onset (AO) trios) and an independent case-control sample (120 healthy subjects (HS), 87 EO and 138 AO patients). Second, we explored the effect of NRN1 on brain activity during a working memory task (N-back task; 39 HS, 39 EO and 39 AO; matched by age, sex and estimated IQ). Different haplotypes encompassing the same three Single Nucleotide Polymorphisms(SNPs, rs3763180-rs10484320-rs4960155) were associated with EO in the two samples (GCT, TCC and GTT). Besides, the GTT haplotype was associated with worse N-back task performance in EO and was linked to an inefficient dorsolateral prefrontal cortex activity in subjects with EO compared to HS. Our results show convergent evidence on the NRN1 association with EO both from genetic and neuroimaging approaches, highlighting the role of neurotrophins in the pathophysiology of SZ.This study received funding provided by: (i) Fundación Alicia Koplowitz; (ii) Acadèmiade les Ciències Mèdiques i de la Salut de Catalunya i de Balears (predoctoral contract to C.A.-P.);(iii) the Instituto de Salud Carlos III through a PFIS predoctoral contract to M.G.-R. (FI19/0352) and aMiguel Servet contract to M.F.-V. (CP20/00072), co-funded by European Regional Development Fund(ERDF)/European Social Fund “Investing in your future”; (iv) the Comissionat per a Universitatsi Recerca del DIUE of the Generalitat de Catalunya (Agència de Gestiód’Ajuts Universitaris i deRecerca (AGAUR), 2017SGR1271 and 2017SGR1577)MDPI202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/ijms23137456http://hdl.handle.net/10459.1/83669http://hdl.handle.net/10459.1/83669reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a : https://doi.org/10.3390/ijms23137456International Journal of Molecular Science, 2022, vol. 23, núm. 13cc-by (c) the authors, 2022info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/836692026-05-29T05:05:01Z
dc.title.none.fl_str_mv NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
title NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
spellingShingle NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
Almodóvar Payá, Carmen
NRN1
Age at onset
Functional magnetic resonance imaging (fMRI)
Schizophrenia-spectrum disorders
Working memory
title_short NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
title_full NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
title_fullStr NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
title_full_unstemmed NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
title_sort NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
dc.creator.none.fl_str_mv Almodóvar Payá, Carmen
Guardiola Ripoll, Maria
Giralt López, Maria
Gallego, Carme
Salgado Pineda, Pilar
Miret, Salvador
Salvador, Raymond
Muñoz, María J.
Lázaro, Luisa
Guerrero Pedraza, Amalia
Parellada, Mara
Carrión, María I.
Cuesta, Manuel J.
Maristany, Teresa
Sarró, Salvador
Fañanás Saura, Lourdes
Callado, Luis F.
Arias, Bárbara
Pomarol-Clotet, Edith
Fatjó-Vilas, Mar
author Almodóvar Payá, Carmen
author_facet Almodóvar Payá, Carmen
Guardiola Ripoll, Maria
Giralt López, Maria
Gallego, Carme
Salgado Pineda, Pilar
Miret, Salvador
Salvador, Raymond
Muñoz, María J.
Lázaro, Luisa
Guerrero Pedraza, Amalia
Parellada, Mara
Carrión, María I.
Cuesta, Manuel J.
Maristany, Teresa
Sarró, Salvador
Fañanás Saura, Lourdes
Callado, Luis F.
Arias, Bárbara
Pomarol-Clotet, Edith
Fatjó-Vilas, Mar
author_role author
author2 Guardiola Ripoll, Maria
Giralt López, Maria
Gallego, Carme
Salgado Pineda, Pilar
Miret, Salvador
Salvador, Raymond
Muñoz, María J.
Lázaro, Luisa
Guerrero Pedraza, Amalia
Parellada, Mara
Carrión, María I.
Cuesta, Manuel J.
Maristany, Teresa
Sarró, Salvador
Fañanás Saura, Lourdes
Callado, Luis F.
Arias, Bárbara
Pomarol-Clotet, Edith
Fatjó-Vilas, Mar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NRN1
Age at onset
Functional magnetic resonance imaging (fMRI)
Schizophrenia-spectrum disorders
Working memory
topic NRN1
Age at onset
Functional magnetic resonance imaging (fMRI)
Schizophrenia-spectrum disorders
Working memory
description Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic association analyses using a family-based sample (80 early-onset (EO) trios (offspring onset ≤ 18 years) and 71 adult-onset (AO) trios) and an independent case-control sample (120 healthy subjects (HS), 87 EO and 138 AO patients). Second, we explored the effect of NRN1 on brain activity during a working memory task (N-back task; 39 HS, 39 EO and 39 AO; matched by age, sex and estimated IQ). Different haplotypes encompassing the same three Single Nucleotide Polymorphisms(SNPs, rs3763180-rs10484320-rs4960155) were associated with EO in the two samples (GCT, TCC and GTT). Besides, the GTT haplotype was associated with worse N-back task performance in EO and was linked to an inefficient dorsolateral prefrontal cortex activity in subjects with EO compared to HS. Our results show convergent evidence on the NRN1 association with EO both from genetic and neuroimaging approaches, highlighting the role of neurotrophins in the pathophysiology of SZ.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/ijms23137456
http://hdl.handle.net/10459.1/83669
http://hdl.handle.net/10459.1/83669
url https://doi.org/10.3390/ijms23137456
http://hdl.handle.net/10459.1/83669
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a : https://doi.org/10.3390/ijms23137456
International Journal of Molecular Science, 2022, vol. 23, núm. 13
dc.rights.none.fl_str_mv cc-by (c) the authors, 2022
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) the authors, 2022
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421023567282176
score 15,198674

Registos relacionados