New aproaches for in vitro diagnosis of LTP Syndrome
[eng] I. INTRODUCTION LTPs (lipid transfer proteins) are allergens relevant mainly in the Mediterranean basin, widely distributed in plant foods, pollen and latex (panallergens). Cross-reactivity between LTPs from different allergenic sources is very high, so it is common for patients to present com...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/213161 |
| Acceso en línea: | https://hdl.handle.net/2445/213161 http://hdl.handle.net/10803/691445 |
| Access Level: | acceso abierto |
| Palabra clave: | Immunologia Al·lèrgia alimentària Diagnòstic Immunology Food allergy Diagnosis |
| Sumario: | [eng] I. INTRODUCTION LTPs (lipid transfer proteins) are allergens relevant mainly in the Mediterranean basin, widely distributed in plant foods, pollen and latex (panallergens). Cross-reactivity between LTPs from different allergenic sources is very high, so it is common for patients to present complex sensitization profiles to LTPs from multiple different sources, the clinical expression of which can be highly variable (LTP Syndrome). Treatment is fundamentally based on the exclusion diet. For in vitro diagnosis, serum IgE-specific (sIgE) is evaluated by various immunoassays. Component-based diagnosis allows for a more accurate patient sensitization profile, as well as better clinical characterization, opening up the possibility of a more individualized therapeutic intervention. II. HYPOTHESES AND OBJECTIVES HYPOTHESES: Component-based diagnostic tools are useful for establishing molecular profiles in LTP Syndrome. A deeper knowledge and optimization of in vitro immunoassays would allow the identification of diverse phenotypic profiles in LTP Syndrome, offering a personalized diagnosis and therapeutic intervention. OBJECTIVES: The main objective is to improve the usefulness of the in vitro tools used for the diagnosis of allergy to LTP as well as the clinical management of patients. 1. To improve the usefulness of current in vitro tools for the diagnosis and clinical management of patients with LTP Syndrome. 2. To develop new in vitro tools based on molecular diagnosis to improve the diagnosis and therapeutic management of patients with LTP Syndrome. |
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