Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition

Background Maternal nutritional status and dietary profile during pregnancy and lactation have short-and long-term impacts on offspring health. However, there is an incomplete understanding of the mechanisms behind these health effects. This study aims to assess the effect of maternal diet on the he...

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Autores: Rio-Aige K, Selma-Royo M, Cabrera-Rubio R, González S, Martínez-Costa C, Castell M, Rodríguez-Lagunas MJ, Collado MC, Pérez-Cano FJ
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p20236
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/20236
Access Level:acceso abierto
Palavra-chave:Human milk IgA
Infant health
Gastroenteritis
Fibre
Vegetable protein
Gut microbiota
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spelling Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk compositionRio-Aige KSelma-Royo MCabrera-Rubio RGonzález SMartínez-Costa CCastell MRodríguez-Lagunas MJCollado MCPérez-Cano FJHuman milk IgAInfant healthGastroenteritisFibreVegetable proteinGut microbiotaBackground Maternal nutritional status and dietary profile during pregnancy and lactation have short-and long-term impacts on offspring health. However, there is an incomplete understanding of the mechanisms behind these health effects. This study aims to assess the effect of maternal diet on the health of offspring by examining to unravel the impact of maternal diet on offspring health outcomes and evaluate the link between maternal nutrition, human milk immune components and neonatal colonisation as potential mechanisms that mediate the influence of maternal diet in the incidence of infant infections. Methods To assess this objective, we used two complementary approaches by which a clinical observational study based on the MAMI birth cohort guided a preclinical interventional analysis using a neonatal rat model of rotavirusinduced gastroenteritis. Findings The findings in both approaches demonstrated that a maternal diet rich in plant-based protein, fibre and polyunsaturated fatty acids, was linked to reduced incidence and severity of infections in offspring that would be mediated by beneficial modulation of the gut microbiota and immune system. Specifically, in the suckling rats, a predominant Th1 immune response and an enhanced virus-specific response were observed. Moreover, human milk IgA and rat milk IgG2c played a key protective role that complemented the effects of maternal diet. Interpretation These results strengthen the importance of maternal diet during pregnancy and lactation supporting infant health. Funding The study was supported by LaMarat & oacute;-TV3 (DIM-2-ELI, ref. 2018-27/30-31). Copyright (c) 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 2025;118: Published 2025 https://doi.org/10. 1016/j.ebiom.2025. 105850ELSEVIER2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/20236EBioMedicineISSN: 23523964reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p202362026-06-07T16:35:31Z
dc.title.none.fl_str_mv Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition
title Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition
spellingShingle Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition
Rio-Aige K
Human milk IgA
Infant health
Gastroenteritis
Fibre
Vegetable protein
Gut microbiota
title_short Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition
title_full Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition
title_fullStr Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition
title_full_unstemmed Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition
title_sort Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition
dc.creator.none.fl_str_mv Rio-Aige K
Selma-Royo M
Cabrera-Rubio R
González S
Martínez-Costa C
Castell M
Rodríguez-Lagunas MJ
Collado MC
Pérez-Cano FJ
author Rio-Aige K
author_facet Rio-Aige K
Selma-Royo M
Cabrera-Rubio R
González S
Martínez-Costa C
Castell M
Rodríguez-Lagunas MJ
Collado MC
Pérez-Cano FJ
author_role author
author2 Selma-Royo M
Cabrera-Rubio R
González S
Martínez-Costa C
Castell M
Rodríguez-Lagunas MJ
Collado MC
Pérez-Cano FJ
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Human milk IgA
Infant health
Gastroenteritis
Fibre
Vegetable protein
Gut microbiota
topic Human milk IgA
Infant health
Gastroenteritis
Fibre
Vegetable protein
Gut microbiota
description Background Maternal nutritional status and dietary profile during pregnancy and lactation have short-and long-term impacts on offspring health. However, there is an incomplete understanding of the mechanisms behind these health effects. This study aims to assess the effect of maternal diet on the health of offspring by examining to unravel the impact of maternal diet on offspring health outcomes and evaluate the link between maternal nutrition, human milk immune components and neonatal colonisation as potential mechanisms that mediate the influence of maternal diet in the incidence of infant infections. Methods To assess this objective, we used two complementary approaches by which a clinical observational study based on the MAMI birth cohort guided a preclinical interventional analysis using a neonatal rat model of rotavirusinduced gastroenteritis. Findings The findings in both approaches demonstrated that a maternal diet rich in plant-based protein, fibre and polyunsaturated fatty acids, was linked to reduced incidence and severity of infections in offspring that would be mediated by beneficial modulation of the gut microbiota and immune system. Specifically, in the suckling rats, a predominant Th1 immune response and an enhanced virus-specific response were observed. Moreover, human milk IgA and rat milk IgG2c played a key protective role that complemented the effects of maternal diet. Interpretation These results strengthen the importance of maternal diet during pregnancy and lactation supporting infant health. Funding The study was supported by LaMarat & oacute;-TV3 (DIM-2-ELI, ref. 2018-27/30-31). Copyright (c) 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 2025;118: Published 2025 https://doi.org/10. 1016/j.ebiom.2025. 105850
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/20236
url https://incliva.portalinvestigacion.com/publicaciones/20236
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv EBioMedicine
ISSN: 23523964
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
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