Is bone marrow trephine biopsy necessary in multiple myeloma patients at diagnosis?

Multiple myeloma (MM) diagnosis requires 10% plasma cell (PC) infiltration in the bone marrow (BM), detected by bone marrow aspiration (BMA) or biopsy (BMB). We evaluated the concordance of these 2 techniques in 189 patients. In 43 cases (23%), the techniques were discordant, 10 due to poor sample q...

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Detalles Bibliográficos
Autores: Gea, Ana, Fernández, Tatiana, Fernández Luis, Sara, Domínguez García, Juan José, Francés, Irene, Tobalina, Ana, Cantera, Rodrigo, Bannatyne, Julia, Gorostidi, Irene, Oviedo, María, Cerezo, Juan M., García, Raquel, Insunza Gaminde, Andrés, Montes Gaisán, Carmen María, Bermúdez, Aránzazu, Montes Moreno, Santiago|||0000-0002-3565-8262, Briz, Montserrat, Ocio San Miguel, Enrique María|||0000-0002-5765-0085
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:dnet:ucreareposit::981794043ff07d2bbf8b91c5bc2e0975
Acceso en línea:https://hdl.handle.net/10902/36641
Access Level:acceso abierto
Palabra clave:Bone marrow
Aspirate
Multiple myeloma
Descripción
Sumario:Multiple myeloma (MM) diagnosis requires 10% plasma cell (PC) infiltration in the bone marrow (BM), detected by bone marrow aspiration (BMA) or biopsy (BMB). We evaluated the concordance of these 2 techniques in 189 patients. In 43 cases (23%), the techniques were discordant, 10 due to poor sample quality. In the remaining 33 patients, BMB diagnosed MM, while BMA detected < 10% PC, being symptomatic in 16 patients and smouldering (SMM) in 17. Without an initial BMB, 11% would have been misdiagnosed; and 12% of symptomatic patients would require a second BMA or BMB for strict diagnosis according to current criteria.

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