Hereditary leiomyomatosis and renal cell cancer syndrome in spain

Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is a very rare hereditary disorder characterized by cutaneous leiomyomas (CLMs), uterine leiomyomas (ULMs), renal cysts (RCys) and renal cell cancers (RCCs). We aimed to describe the genetics, clinical features and potential genotype-p...

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Detalles Bibliográficos
Autores: Sánchez-Heras, Ana Beatriz|||0000-0003-1742-5374, Castillejo Castillo, Adela|||0000-0002-9581-6285, García-Díaz, Juan D., Robledo, Mercedes|||0000-0001-6256-5902, Teulé, Alexandre, Sánchez, Rosario, Zúñiga, Ángel, Lastra, Enrique, Durán, Mercedes|||0000-0002-6301-9732, Llort, Gemma|||0000-0001-9987-7862, Yagüe, Carmen, Ramon y Cajal, Teresa|||0000-0003-3490-3585, López San Martin, Consol, López-Fernández, Adrià|||0000-0002-2844-5998, Balmaña Gelpí, Judith|||0000-0002-0762-6415, Robles, Luis, Mesa-Latorre, José M., Chirivella, Isabel|||0000-0002-0733-3276, Fonfria, María, Ibañez, Raquel Perea, Castillejo, M.Isabel, Escandell, Inés, Gomez, Luis, Berbel, Pere, Soto, José Luis
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:284412
Acceso en línea:https://ddd.uab.cat/record/284412
https://dx.doi.org/urn:doi:10.3390/cancers12113277
Access Level:acceso abierto
Palabra clave:FH gene
Hereditary leiomyomatosis
Leiomyomas
Missense pathogenic variants
Renal cell cancer
Descripción
Sumario:Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is a very rare hereditary disorder characterized by cutaneous leiomyomas (CLMs), uterine leiomyomas (ULMs), renal cysts (RCys) and renal cell cancers (RCCs). We aimed to describe the genetics, clinical features and potential genotype-phenotype associations in the largest cohort of fumarate hydratase enzyme mutation carriers known from Spain using a multicentre, retrospective study of individuals with a genetic or clinical diagnosis of HLRCC. We collected clinical information from medical records, analysed genetic variants and looked for genotype-phenotype associations. Analyses were performed using R 3.6.0. software. We included 197 individuals: 74 index cases and 123 relatives. CLMs were diagnosed in 65% of patients, ULMs in 90% of women, RCys in 37% and RCC in 10.9%. Twenty-seven different pathogenic variants were detected, 12 (44%) of them not reported previously. Patients with missense pathogenic variants showed higher frequencies of CLMs, ULMs and RCys, than those with loss-of-function variants (p = 0.0380, p = 0.0015 and p = 0.024, respectively). This is the first report of patients with HLRCC from Spain. The frequency of RCCs was lower than those reported in the previously published series. Individuals with missense pathogenic variants had higher frequencies of CLMs, ULMs and RCys.

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