Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain
Hepatitis C virus (HCV) is a major cause of chronic liver infection with 71 million people infected worldwide. Pakistan has the second highest prevalence of HCV infection and more than half (52%) of Pakistani living in Spain reside in Barcelona. The aim of this study was to analyse the seroprevalenc...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:292194 |
| Acesso em linha: | https://ddd.uab.cat/record/292194 https://dx.doi.org/urn:doi:10.2147/IDR.S367715 |
| Access Level: | acceso abierto |
| Palavra-chave: | Hepatitis C virus Migrants HCV genotype HCV subtype |
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Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, SpainDopico, Eva|||0000-0002-5306-3035Rodríguez Frías, Francisco|||0000-0002-9128-7013Ubillos, Itziar|||0000-0002-0993-0058Rando-Segura, Ariadna|||0000-0003-4555-7286Garcia-Cehic, D.|||0000-0002-0009-038XGregori i Font, Josep|||0000-0002-4253-8015Rando-Matos, Yolanda|||0000-0002-4274-5006Solsona, LuisNiubó, Jordi|||0000-0001-9511-0138Esteban Mur, Juan Ignacio|||0000-0001-5085-917XCosta, Josep|||0000-0001-7978-0748Martínez, Miguel J.|||0000-0002-0682-1075Quer, Josep|||0000-0003-0014-084XHepatitis C virusMigrantsHCV genotypeHCV subtypeHepatitis C virus (HCV) is a major cause of chronic liver infection with 71 million people infected worldwide. Pakistan has the second highest prevalence of HCV infection and more than half (52%) of Pakistani living in Spain reside in Barcelona. The aim of this study was to analyse the seroprevalence and viraemic rate and determine the genotypes and subtypes of HCV among Pakistanis living in the southern metropolitan area of Barcelona. We included all Pakistani patients seeking primary healthcare in the southern metropolitan area of Barcelona from August 2011 to July 2014. Serum samples were screened for HCV antibodies. HCV viral load was determined by reverse transcription polymerase chain reaction and genotypes and subtypes were performed using Versant HCV Genotype and/or deep-sequencing. Screening for hepatitis B virus (HBV) was also carried out. Among 5877 Pakistani patients, 565 (9.61%) were screened for anti-HCV antibodies, with 68 (12.04%) being positive. The viral load was determined in 65, with 31 presenting active infection and the viraemic rate was 47.69% (95% confidence interval 36.02-59.62). HCV genotyping and subtyping were performed in 24 individuals. Most infections corresponded to HCV genotype 3 (91.67%), and high resolution HCV subtyping was performed in 18 samples, 16 of which presented subtype 3a. One subject presented HBV coinfection with undetectable HBV DNA. During the study period, we identified a possible case of HCV vertical transmission followed by spontaneous viraemia clearance in a chronically infected mother with a C/T IL28B genetic polymorphism. These results suggest that general HCV screening protocols in patients from high prevalence countries, such as Pakistan, would be helpful to identify and treat active HCV infections. This could avoid further transmission and contribute to building targeted health policies for micro-elimination of HCV infection in specific communities. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/292194https://dx.doi.org/urn:doi:10.2147/IDR.S367715reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00301Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00533open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2921942026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain |
| title |
Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain |
| spellingShingle |
Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain Dopico, Eva|||0000-0002-5306-3035 Hepatitis C virus Migrants HCV genotype HCV subtype |
| title_short |
Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain |
| title_full |
Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain |
| title_fullStr |
Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain |
| title_full_unstemmed |
Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain |
| title_sort |
Prevalence of Hepatitis C Virus Infection, Genotypes and Subtypes in Migrants from Pakistan in Barcelona, Spain |
| dc.creator.none.fl_str_mv |
Dopico, Eva|||0000-0002-5306-3035 Rodríguez Frías, Francisco|||0000-0002-9128-7013 Ubillos, Itziar|||0000-0002-0993-0058 Rando-Segura, Ariadna|||0000-0003-4555-7286 Garcia-Cehic, D.|||0000-0002-0009-038X Gregori i Font, Josep|||0000-0002-4253-8015 Rando-Matos, Yolanda|||0000-0002-4274-5006 Solsona, Luis Niubó, Jordi|||0000-0001-9511-0138 Esteban Mur, Juan Ignacio|||0000-0001-5085-917X Costa, Josep|||0000-0001-7978-0748 Martínez, Miguel J.|||0000-0002-0682-1075 Quer, Josep|||0000-0003-0014-084X |
| author |
Dopico, Eva|||0000-0002-5306-3035 |
| author_facet |
Dopico, Eva|||0000-0002-5306-3035 Rodríguez Frías, Francisco|||0000-0002-9128-7013 Ubillos, Itziar|||0000-0002-0993-0058 Rando-Segura, Ariadna|||0000-0003-4555-7286 Garcia-Cehic, D.|||0000-0002-0009-038X Gregori i Font, Josep|||0000-0002-4253-8015 Rando-Matos, Yolanda|||0000-0002-4274-5006 Solsona, Luis Niubó, Jordi|||0000-0001-9511-0138 Esteban Mur, Juan Ignacio|||0000-0001-5085-917X Costa, Josep|||0000-0001-7978-0748 Martínez, Miguel J.|||0000-0002-0682-1075 Quer, Josep|||0000-0003-0014-084X |
| author_role |
author |
| author2 |
Rodríguez Frías, Francisco|||0000-0002-9128-7013 Ubillos, Itziar|||0000-0002-0993-0058 Rando-Segura, Ariadna|||0000-0003-4555-7286 Garcia-Cehic, D.|||0000-0002-0009-038X Gregori i Font, Josep|||0000-0002-4253-8015 Rando-Matos, Yolanda|||0000-0002-4274-5006 Solsona, Luis Niubó, Jordi|||0000-0001-9511-0138 Esteban Mur, Juan Ignacio|||0000-0001-5085-917X Costa, Josep|||0000-0001-7978-0748 Martínez, Miguel J.|||0000-0002-0682-1075 Quer, Josep|||0000-0003-0014-084X |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Hepatitis C virus Migrants HCV genotype HCV subtype |
| topic |
Hepatitis C virus Migrants HCV genotype HCV subtype |
| description |
Hepatitis C virus (HCV) is a major cause of chronic liver infection with 71 million people infected worldwide. Pakistan has the second highest prevalence of HCV infection and more than half (52%) of Pakistani living in Spain reside in Barcelona. The aim of this study was to analyse the seroprevalence and viraemic rate and determine the genotypes and subtypes of HCV among Pakistanis living in the southern metropolitan area of Barcelona. We included all Pakistani patients seeking primary healthcare in the southern metropolitan area of Barcelona from August 2011 to July 2014. Serum samples were screened for HCV antibodies. HCV viral load was determined by reverse transcription polymerase chain reaction and genotypes and subtypes were performed using Versant HCV Genotype and/or deep-sequencing. Screening for hepatitis B virus (HBV) was also carried out. Among 5877 Pakistani patients, 565 (9.61%) were screened for anti-HCV antibodies, with 68 (12.04%) being positive. The viral load was determined in 65, with 31 presenting active infection and the viraemic rate was 47.69% (95% confidence interval 36.02-59.62). HCV genotyping and subtyping were performed in 24 individuals. Most infections corresponded to HCV genotype 3 (91.67%), and high resolution HCV subtyping was performed in 18 samples, 16 of which presented subtype 3a. One subject presented HBV coinfection with undetectable HBV DNA. During the study period, we identified a possible case of HCV vertical transmission followed by spontaneous viraemia clearance in a chronically infected mother with a C/T IL28B genetic polymorphism. These results suggest that general HCV screening protocols in patients from high prevalence countries, such as Pakistan, would be helpful to identify and treat active HCV infections. This could avoid further transmission and contribute to building targeted health policies for micro-elimination of HCV infection in specific communities. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
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Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/292194 https://dx.doi.org/urn:doi:10.2147/IDR.S367715 |
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https://ddd.uab.cat/record/292194 https://dx.doi.org/urn:doi:10.2147/IDR.S367715 |
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Inglés eng |
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Inglés |
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eng |
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Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00301 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00533 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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