Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents

Orexin-A, a hormone secreted by orexin neurons, is involved in caloric-intake regulation. Current understanding is based primarily on animal studies. Studies of orexin in humans are scarce, and to our knowledge there are no prior studies in adolescents. We studied fasting Orexin-A levels related to...

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Authors: Lanuza Rilling, Fabián Ignacio, Reyes, Marcela, Blanco, Estela, Burrows, Raquel, Peirano, Patricio, Algarín, Cecilia, Meroño, Tomás, Gahagan, Sheila
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/192637
Online Access:https://hdl.handle.net/2445/192637
Access Level:Open access
Keyword:Obesitat
Adolescents
Obesity
Teenagers
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spelling Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescentsLanuza Rilling, Fabián IgnacioReyes, MarcelaBlanco, EstelaBurrows, RaquelPeirano, PatricioAlgarín, CeciliaMeroño, TomásGahagan, SheilaObesitatAdolescentsObesityTeenagersOrexin-A, a hormone secreted by orexin neurons, is involved in caloric-intake regulation. Current understanding is based primarily on animal studies. Studies of orexin in humans are scarce, and to our knowledge there are no prior studies in adolescents. We studied fasting Orexin-A levels related to energy intake at breakfast and a subsequent snack in adolescents (n = 668) from a longitudinal study in Chile. Body-Mass Index (BMI), components of the metabolic syndrome and fasting blood levels of leptin, insulin, ghrelin, and orexin-A were measured. Energy intake was calculated based on food weights before and after the standardized breakfast and subsequent snack. High energy intake was defined as ≥ 75th percentile. We assessed the relationship between orexin-A and high energy intake, adjusting for confounders. Higher orexin levels were associated with high breakfast energy intake (OR: 1.21; 95%CI: 0.98-1.49). Conversely, those with higher orexin levels showed a non-significant trend for lower odds of high energy intake for the snack (OR: 0.87; 95%CI: 0.70-1.07). There was a significant interaction between high breakfast energy intake and orexin levels. Those who ate more calories at breakfast displayed a lower inhibitory effect of orexin on eating at the snack (p < 0.05). There was no significant interaction between weight status and orexin. In conclusion, orexin-A levels were associated with breakfast energy intake and inversely related with subsequent snack energy intake in participants whose caloric intake at breakfast was within the normal range. Based on these findings, it appears that the association of orexin-A with energy intake depends on eating behavior.Elsevier Ltd2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/192637Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.psyneuen.2022.105679Psychoneuroendocrinology, 2022, vol. 138, num. 10https://doi.org/10.1016/j.psyneuen.2022.105679cc-by (c) Fabian Lanuza, 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1926372026-05-29T05:05:01Z
dc.title.none.fl_str_mv Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
title Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
spellingShingle Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
Lanuza Rilling, Fabián Ignacio
Obesitat
Adolescents
Obesity
Teenagers
title_short Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
title_full Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
title_fullStr Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
title_full_unstemmed Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
title_sort Association of fasting Orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
dc.creator.none.fl_str_mv Lanuza Rilling, Fabián Ignacio
Reyes, Marcela
Blanco, Estela
Burrows, Raquel
Peirano, Patricio
Algarín, Cecilia
Meroño, Tomás
Gahagan, Sheila
author Lanuza Rilling, Fabián Ignacio
author_facet Lanuza Rilling, Fabián Ignacio
Reyes, Marcela
Blanco, Estela
Burrows, Raquel
Peirano, Patricio
Algarín, Cecilia
Meroño, Tomás
Gahagan, Sheila
author_role author
author2 Reyes, Marcela
Blanco, Estela
Burrows, Raquel
Peirano, Patricio
Algarín, Cecilia
Meroño, Tomás
Gahagan, Sheila
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Adolescents
Obesity
Teenagers
topic Obesitat
Adolescents
Obesity
Teenagers
description Orexin-A, a hormone secreted by orexin neurons, is involved in caloric-intake regulation. Current understanding is based primarily on animal studies. Studies of orexin in humans are scarce, and to our knowledge there are no prior studies in adolescents. We studied fasting Orexin-A levels related to energy intake at breakfast and a subsequent snack in adolescents (n = 668) from a longitudinal study in Chile. Body-Mass Index (BMI), components of the metabolic syndrome and fasting blood levels of leptin, insulin, ghrelin, and orexin-A were measured. Energy intake was calculated based on food weights before and after the standardized breakfast and subsequent snack. High energy intake was defined as ≥ 75th percentile. We assessed the relationship between orexin-A and high energy intake, adjusting for confounders. Higher orexin levels were associated with high breakfast energy intake (OR: 1.21; 95%CI: 0.98-1.49). Conversely, those with higher orexin levels showed a non-significant trend for lower odds of high energy intake for the snack (OR: 0.87; 95%CI: 0.70-1.07). There was a significant interaction between high breakfast energy intake and orexin levels. Those who ate more calories at breakfast displayed a lower inhibitory effect of orexin on eating at the snack (p < 0.05). There was no significant interaction between weight status and orexin. In conclusion, orexin-A levels were associated with breakfast energy intake and inversely related with subsequent snack energy intake in participants whose caloric intake at breakfast was within the normal range. Based on these findings, it appears that the association of orexin-A with energy intake depends on eating behavior.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192637
url https://hdl.handle.net/2445/192637
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.psyneuen.2022.105679
Psychoneuroendocrinology, 2022, vol. 138, num. 10
https://doi.org/10.1016/j.psyneuen.2022.105679
dc.rights.none.fl_str_mv cc-by (c) Fabian Lanuza, 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Fabian Lanuza, 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd
publisher.none.fl_str_mv Elsevier Ltd
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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