Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments

This study aims to assess the neuroprotective effect of AD4 against organophosphate-induced neurotoxicity. Experiments were conducted in a murine model that survives paraoxon exposure. Animals received either serum or AD4 as post-treatment therapy. Behavioral assessments were performed several days...

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Detalles Bibliográficos
Autores: López-Arnau, Raúl, Urquizu, Edurne, Cuiller, Marine, Papadopoulou, Georgia, Pubill, David, Raldua, Demetrio, Camarasa, Jorge, Escubedo, Elena
Tipo de recurso: conjunto de datos
Fecha de publicación:2025
País:España
Institución:Consorci de Serveis Universitaris de Catalunya (CSUC)
Repositorio:CORA.Repositori de Dades de Recerca
OAI Identifier:oai:dnet:cora.rdr____::4f18b4c7a669f1e58a002df8273a56c5
Acceso en línea:https://doi.org/10.34810/DATA2785
Access Level:acceso abierto
Palabra clave:Medicine, Health and Life Sciences
Paraoxon
Memory
Oxidative stress
Neuroinflammation
Organophosphorus
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spelling Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-mentsLópez-Arnau, RaúlUrquizu, EdurneCuiller, MarinePapadopoulou, GeorgiaPubill, DavidRaldua, DemetrioCamarasa, JorgeEscubedo, ElenaMedicine, Health and Life SciencesParaoxonMemoryOxidative stressNeuroinflammationOrganophosphorusThis study aims to assess the neuroprotective effect of AD4 against organophosphate-induced neurotoxicity. Experiments were conducted in a murine model that survives paraoxon exposure. Animals received either serum or AD4 as post-treatment therapy. Behavioral assessments were performed several days later to evaluate motor activity (HLA) and memory (NORT). Following euthanasia, proteins were extracted from distinct brain regions to analyze the expression of GPX, catalase, and lipid peroxidation marker 4-HNE. Additional animals were perfused, and brain sections were processed for immunohistochemical quantification of GFAP and IBA-1. The results demonstrate that AD4 26 mitigates oxidative stress, neuroinflammation, and cognitive dysfunction following acute paraoxon intoxication.CORA.Repositori de Dades de RecercaEscubedo Rafa, Elena2025info:eu-repo/semantics/datasethttps://doi.org/10.34810/DATA2785reponame:CORA.Repositori de Dades de Recercainstname:Consorci de Serveis Universitaris de Catalunya (CSUC)Inglésinfo:eu-repo/semantics/openAccessCC BY 4.0oai:dnet:cora.rdr____::4f18b4c7a669f1e58a002df8273a56c52026-06-17T12:20:17Z
dc.title.none.fl_str_mv Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments
title Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments
spellingShingle Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments
López-Arnau, Raúl
Medicine, Health and Life Sciences
Paraoxon
Memory
Oxidative stress
Neuroinflammation
Organophosphorus
title_short Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments
title_full Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments
title_fullStr Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments
title_full_unstemmed Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments
title_sort Replication Data for: Neuroprotective effects of N-acetylcysteine-amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impair-ments
dc.creator.none.fl_str_mv López-Arnau, Raúl
Urquizu, Edurne
Cuiller, Marine
Papadopoulou, Georgia
Pubill, David
Raldua, Demetrio
Camarasa, Jorge
Escubedo, Elena
author López-Arnau, Raúl
author_facet López-Arnau, Raúl
Urquizu, Edurne
Cuiller, Marine
Papadopoulou, Georgia
Pubill, David
Raldua, Demetrio
Camarasa, Jorge
Escubedo, Elena
author_role author
author2 Urquizu, Edurne
Cuiller, Marine
Papadopoulou, Georgia
Pubill, David
Raldua, Demetrio
Camarasa, Jorge
Escubedo, Elena
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escubedo Rafa, Elena
dc.subject.none.fl_str_mv Medicine, Health and Life Sciences
Paraoxon
Memory
Oxidative stress
Neuroinflammation
Organophosphorus
topic Medicine, Health and Life Sciences
Paraoxon
Memory
Oxidative stress
Neuroinflammation
Organophosphorus
description This study aims to assess the neuroprotective effect of AD4 against organophosphate-induced neurotoxicity. Experiments were conducted in a murine model that survives paraoxon exposure. Animals received either serum or AD4 as post-treatment therapy. Behavioral assessments were performed several days later to evaluate motor activity (HLA) and memory (NORT). Following euthanasia, proteins were extracted from distinct brain regions to analyze the expression of GPX, catalase, and lipid peroxidation marker 4-HNE. Additional animals were perfused, and brain sections were processed for immunohistochemical quantification of GFAP and IBA-1. The results demonstrate that AD4 26 mitigates oxidative stress, neuroinflammation, and cognitive dysfunction following acute paraoxon intoxication.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
format dataset
dc.identifier.none.fl_str_mv https://doi.org/10.34810/DATA2785
url https://doi.org/10.34810/DATA2785
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
CC BY 4.0
eu_rights_str_mv openAccess
rights_invalid_str_mv CC BY 4.0
dc.publisher.none.fl_str_mv CORA.Repositori de Dades de Recerca
publisher.none.fl_str_mv CORA.Repositori de Dades de Recerca
dc.source.none.fl_str_mv reponame:CORA.Repositori de Dades de Recerca
instname:Consorci de Serveis Universitaris de Catalunya (CSUC)
instname_str Consorci de Serveis Universitaris de Catalunya (CSUC)
reponame_str CORA.Repositori de Dades de Recerca
collection CORA.Repositori de Dades de Recerca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420922409058304
score 15,812429

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