Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial

The use of garlic (Allium sativum) for treating arterial hypertension has been recognized as effective for several decades. However, tolerance to treatment is low, and several technological modifications have been developed to improve its tolerability, such as the aging process at controlled tempera...

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Autores: Serrano Casasola, José Carlos Enrique, Castro-Boqué, Eva, García-Carrasco, Alicia, Morán-Valero, María Inés, González-Hedström, Daniel, Bermúdez López, Marcelino, Valdivielso Revilla, José Manuel, Espinel, Alberto E., Portero Otín, Manuel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/464131
Acesso em linha:https://doi.org/10.3390/nu15173691
https://hdl.handle.net/10459.1/464131
Access Level:acceso abierto
Palavra-chave:Hypertension
Aged black garlic
Blood pressure
S-allyl-cysteine
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spelling Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled TrialSerrano Casasola, José Carlos EnriqueCastro-Boqué, EvaGarcía-Carrasco, AliciaMorán-Valero, María InésGonzález-Hedström, DanielBermúdez López, MarcelinoValdivielso Revilla, José ManuelEspinel, Alberto E.Portero Otín, ManuelHypertensionAged black garlicBlood pressureS-allyl-cysteineThe use of garlic (Allium sativum) for treating arterial hypertension has been recognized as effective for several decades. However, tolerance to treatment is low, and several technological modifications have been developed to improve its tolerability, such as the aging process at controlled temperature and humidity. This study aims to validate the antihypertensive effects of an optimized extract of aged black garlic with low doses of s-allyl-cysteine (SAC) in a Grade I hypertensive population with drug treatment. A randomized, triple-blind, placebo-controlled parallel trial was developed, where a daily supplementation with 0.25 mg/day of SAC for 12 weeks was performed. A reduction in systolic and diastolic blood pressure of 1.8 mmHg (0.7 to 4.1 95% CI) and 1.5 mmHg (0.3 to 3.0 95% CI), respectively, was observed. Similarly, an increase in blood nitric oxide (10.3 µM, 1.1 to 19.5 95% CI) and antioxidant capacity (7 × 10−3 µM TE/min, (1.2 to 13 × 10−3 95% CI) and a reduction in uric acid levels (−0.3 mg/dL, −0.5 to −0.001 95% CI) and ACE activity (−9.3 U/L; −18.4 to −0.4 95% CI) were observed. No changes in endothelial function and inflammatory cytokines were observed. It was concluded that low-dose SAC supplementation in an optimized black-garlic extract allows for an extra-significant reduction in blood pressure in a Grade I hypertensive population receiving drug treatment.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/nu15173691https://hdl.handle.net/10459.1/464131reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.3390/nu15173691Nutrients, 2023, vol. 15, núm. 17, 3691cc-by (c) José C. E. Serrano et al., 2023Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/4641312026-05-29T05:05:01Z
dc.title.none.fl_str_mv Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
title Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
spellingShingle Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
Serrano Casasola, José Carlos Enrique
Hypertension
Aged black garlic
Blood pressure
S-allyl-cysteine
title_short Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
title_full Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
title_fullStr Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
title_full_unstemmed Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
title_sort Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial
dc.creator.none.fl_str_mv Serrano Casasola, José Carlos Enrique
Castro-Boqué, Eva
García-Carrasco, Alicia
Morán-Valero, María Inés
González-Hedström, Daniel
Bermúdez López, Marcelino
Valdivielso Revilla, José Manuel
Espinel, Alberto E.
Portero Otín, Manuel
author Serrano Casasola, José Carlos Enrique
author_facet Serrano Casasola, José Carlos Enrique
Castro-Boqué, Eva
García-Carrasco, Alicia
Morán-Valero, María Inés
González-Hedström, Daniel
Bermúdez López, Marcelino
Valdivielso Revilla, José Manuel
Espinel, Alberto E.
Portero Otín, Manuel
author_role author
author2 Castro-Boqué, Eva
García-Carrasco, Alicia
Morán-Valero, María Inés
González-Hedström, Daniel
Bermúdez López, Marcelino
Valdivielso Revilla, José Manuel
Espinel, Alberto E.
Portero Otín, Manuel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hypertension
Aged black garlic
Blood pressure
S-allyl-cysteine
topic Hypertension
Aged black garlic
Blood pressure
S-allyl-cysteine
description The use of garlic (Allium sativum) for treating arterial hypertension has been recognized as effective for several decades. However, tolerance to treatment is low, and several technological modifications have been developed to improve its tolerability, such as the aging process at controlled temperature and humidity. This study aims to validate the antihypertensive effects of an optimized extract of aged black garlic with low doses of s-allyl-cysteine (SAC) in a Grade I hypertensive population with drug treatment. A randomized, triple-blind, placebo-controlled parallel trial was developed, where a daily supplementation with 0.25 mg/day of SAC for 12 weeks was performed. A reduction in systolic and diastolic blood pressure of 1.8 mmHg (0.7 to 4.1 95% CI) and 1.5 mmHg (0.3 to 3.0 95% CI), respectively, was observed. Similarly, an increase in blood nitric oxide (10.3 µM, 1.1 to 19.5 95% CI) and antioxidant capacity (7 × 10−3 µM TE/min, (1.2 to 13 × 10−3 95% CI) and a reduction in uric acid levels (−0.3 mg/dL, −0.5 to −0.001 95% CI) and ACE activity (−9.3 U/L; −18.4 to −0.4 95% CI) were observed. No changes in endothelial function and inflammatory cytokines were observed. It was concluded that low-dose SAC supplementation in an optimized black-garlic extract allows for an extra-significant reduction in blood pressure in a Grade I hypertensive population receiving drug treatment.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/nu15173691
https://hdl.handle.net/10459.1/464131
url https://doi.org/10.3390/nu15173691
https://hdl.handle.net/10459.1/464131
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/nu15173691
Nutrients, 2023, vol. 15, núm. 17, 3691
dc.rights.none.fl_str_mv cc-by (c) José C. E. Serrano et al., 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) José C. E. Serrano et al., 2023
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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