Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents

Recent findings have shifted the view of cholecystokinin (CCK) from being a cellular neuronal marker to being recognized as a crucial neuropeptide pivotal in synaptic plasticity and memory processes. Despite its now appreciated importance in various brain regions and abundance in the basal ganglia,...

Descripción completa

Detalles Bibliográficos
Autores: Guillaume, Chloé, Sáez, María, Parnet, Patricia, Reig, Ramón, Paillé, Vincent
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/387667
Acceso en línea:http://hdl.handle.net/10261/387667
https://api.elsevier.com/content/abstract/scopus_id/105000436352
Access Level:acceso abierto
Palabra clave:Basal ganglia
Cholecystokinin (CCK)
Corticostriatal synapse
Spike-timing–dependent plasticity
id ES_d6c85992ee4c467d580ddb4e7ace391a
oai_identifier_str oai:digital.csic.es:10261/387667
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in RodentsGuillaume, ChloéSáez, MaríaParnet, PatriciaReig, RamónPaillé, VincentBasal gangliaCholecystokinin (CCK)Corticostriatal synapseSpike-timing–dependent plasticityRecent findings have shifted the view of cholecystokinin (CCK) from being a cellular neuronal marker to being recognized as a crucial neuropeptide pivotal in synaptic plasticity and memory processes. Despite its now appreciated importance in various brain regions and abundance in the basal ganglia, its role in the striatum, which is vital for motor control, remains unclear. This study sought to fill this gap by performing a comprehensive investigation of the role of CCK in modulating striatal medium spiny neuron (MSN) membrane properties, as well as the secondary somatosensory cortex S2 to MSN synaptic transmission and plasticity in rodents. Using in vivo optopatch-clamp recording in mice on identified MSNs, we showed that the application of CCK receptor Type 2 (CCK2R) antagonists decreases corticostriatal transmission in both direct and indirect pathway MSNs. Moving to an ex vivo rat preparation to maximize experimental access, we showed that CCK2R inhibition impacts MSN membrane properties by reducing spike threshold and rheobase, suggesting an excitability increase. Moreover, CCK modulates corticostriatal transmission mainly via CCK2R, and CCK2R blockage shifted spike-timing-dependent plasticity from long-term potentiation to long-term depression. Our study advances the understanding of CCK's importance in modulating corticostriatal transmission. By showing how CCK2R blockade influences synaptic function and plasticity, we provide new insights into the mechanisms underlying striatal functions, opening new paths for exploring its potential relevance to neurological disorders involving basal ganglia-related behaviors.We acknowledge Blandine Castellano, Alexis Gandon, and Amandine Lefebvre for taking care of the animals throughout the study, Maeva Rebion for helping in data analysis, and Elisa Galliano for her feedback on this manuscript. This research was supported by AGREENIUM and the University of Nantes (CG) ANSSD - INRAE funding (VP), MICINN, PID2021-129070NB-I00 (R.R.) and NEURO-AGING+, receunag2021 (R.R.).Peer reviewedSociety for NeuroscienceInstitut Agronomique Vétérinaire et Forestier de FranceUniversité de NantesMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Guillaume, Chloé [0000-0002-9732-2975]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/387667https://api.elsevier.com/content/abstract/scopus_id/105000436352reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-129070NB-I00https://doi.org/10.1523/ENEURO.0251-24.2025Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3876672026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents
title Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents
spellingShingle Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents
Guillaume, Chloé
Basal ganglia
Cholecystokinin (CCK)
Corticostriatal synapse
Spike-timing–dependent plasticity
title_short Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents
title_full Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents
title_fullStr Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents
title_full_unstemmed Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents
title_sort Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents
dc.creator.none.fl_str_mv Guillaume, Chloé
Sáez, María
Parnet, Patricia
Reig, Ramón
Paillé, Vincent
author Guillaume, Chloé
author_facet Guillaume, Chloé
Sáez, María
Parnet, Patricia
Reig, Ramón
Paillé, Vincent
author_role author
author2 Sáez, María
Parnet, Patricia
Reig, Ramón
Paillé, Vincent
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Institut Agronomique Vétérinaire et Forestier de France
Université de Nantes
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Guillaume, Chloé [0000-0002-9732-2975]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Basal ganglia
Cholecystokinin (CCK)
Corticostriatal synapse
Spike-timing–dependent plasticity
topic Basal ganglia
Cholecystokinin (CCK)
Corticostriatal synapse
Spike-timing–dependent plasticity
description Recent findings have shifted the view of cholecystokinin (CCK) from being a cellular neuronal marker to being recognized as a crucial neuropeptide pivotal in synaptic plasticity and memory processes. Despite its now appreciated importance in various brain regions and abundance in the basal ganglia, its role in the striatum, which is vital for motor control, remains unclear. This study sought to fill this gap by performing a comprehensive investigation of the role of CCK in modulating striatal medium spiny neuron (MSN) membrane properties, as well as the secondary somatosensory cortex S2 to MSN synaptic transmission and plasticity in rodents. Using in vivo optopatch-clamp recording in mice on identified MSNs, we showed that the application of CCK receptor Type 2 (CCK2R) antagonists decreases corticostriatal transmission in both direct and indirect pathway MSNs. Moving to an ex vivo rat preparation to maximize experimental access, we showed that CCK2R inhibition impacts MSN membrane properties by reducing spike threshold and rheobase, suggesting an excitability increase. Moreover, CCK modulates corticostriatal transmission mainly via CCK2R, and CCK2R blockage shifted spike-timing-dependent plasticity from long-term potentiation to long-term depression. Our study advances the understanding of CCK's importance in modulating corticostriatal transmission. By showing how CCK2R blockade influences synaptic function and plasticity, we provide new insights into the mechanisms underlying striatal functions, opening new paths for exploring its potential relevance to neurological disorders involving basal ganglia-related behaviors.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/387667
https://api.elsevier.com/content/abstract/scopus_id/105000436352
url http://hdl.handle.net/10261/387667
https://api.elsevier.com/content/abstract/scopus_id/105000436352
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-129070NB-I00
https://doi.org/10.1523/ENEURO.0251-24.2025
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420914187173889
score 15.812429

Similares en LA Referencia