Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus

Background and objectives: Systemic Lupus Erythematosus (SLE) follow-up is based on clinical, and analytical parameters. We aimed to determine the differences between the Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR) and Red blood cell distribution width (RDW) between SLE...

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Autores: Moreno Torres, Víctor, Castejon, Raquel, Mellor Pita, Susana Teresa, Tutor de Ureta, Pablo, Durán del Campo, Pedro, Martinez Urbistondo, Maria, Vazquez Comendador, José, Gutierrez Rojas, Ángela, Rosado, Silvia, Vargas Núñez, Juan Antonio
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/713898
Acceso en línea:http://hdl.handle.net/10486/713898
https://dx.doi.org/10.1016/j.jtauto.2022.100157
Access Level:acceso abierto
Palabra clave:IL-6
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
red blood cell distribution width
systemic lupus erythematosus
Medicina
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spelling Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosusMoreno Torres, VíctorCastejon, RaquelMellor Pita, Susana TeresaTutor de Ureta, PabloDurán del Campo, PedroMartinez Urbistondo, MariaVazquez Comendador, JoséGutierrez Rojas, ÁngelaRosado, SilviaVargas Núñez, Juan AntonioIL-6neutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiored blood cell distribution widthsystemic lupus erythematosusMedicinaBackground and objectives: Systemic Lupus Erythematosus (SLE) follow-up is based on clinical, and analytical parameters. We aimed to determine the differences between the Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR) and Red blood cell distribution width (RDW) between SLE patients and healthy controls and to assess their association with anemia status, classical inflammatory biomarkers and cytokines, disease activity, SLE related factors and treatment received for SLE. Methods: Seventy-seven patients with SLE according to 2012 SLICC criteria and 80 healthy controls were included. Patients with SLE were classified in SLE with anemia (SLE-a) and SLE without anemia (SLE-na). Statistical analysis between SLE patients and controls and the association of serological and clinical activity markers with proposed hematological indices among SLE patients were performed. Results: RDW, NLR and PLR, were significantly higher in SLE patients than in healthy control group (p < 0.001), in SLE-a patients as compared to SLE-na (p < 0.0001) and were significantly associated with hypocomplementemia (p < 0.05). PLR was higher in active patients measured by SLEDAI-2K score and with longer disease duration (p < 0.05). RDW was associated with serological activity of the patients (p < 0.05) and was correlated with SLEDAI-2K and SLICC/ACR scores, hsCRP, D-dimer, fibrinogen, IL-6 and TNF as well as with corticosteroids intake (p = 0.05). A logistic regression analysis confirmed that after adjustment by age and hemoglobin values, RDW presented linear correlation with IL-6 levels (Beta-coefficient = 0.369, p = 0.003). Conclusion: NLR, PLR and RDW values suggest SLE serological and clinical activity. Given their availability, these markers not only could be useful tools to identify and monitor active SLE patients but whose application should be considered in inflammatory pathologies orchestrated by IL-6 and TNFThis work has been supported by a grant from Instituto de Salud Carlos III (Expedient number PI16-01480): VMT has a grant from Instituto de Salud Carlos III (CM19/00223).ElsevierDepartamento de MedicinaFacultad de Medicina20222022-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/713898https://dx.doi.org/10.1016/j.jtauto.2022.100157reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7138982026-06-23T12:46:27Z
dc.title.none.fl_str_mv Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus
title Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus
spellingShingle Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus
Moreno Torres, Víctor
IL-6
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
red blood cell distribution width
systemic lupus erythematosus
Medicina
title_short Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus
title_full Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus
title_fullStr Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus
title_full_unstemmed Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus
title_sort Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus
dc.creator.none.fl_str_mv Moreno Torres, Víctor
Castejon, Raquel
Mellor Pita, Susana Teresa
Tutor de Ureta, Pablo
Durán del Campo, Pedro
Martinez Urbistondo, Maria
Vazquez Comendador, José
Gutierrez Rojas, Ángela
Rosado, Silvia
Vargas Núñez, Juan Antonio
author Moreno Torres, Víctor
author_facet Moreno Torres, Víctor
Castejon, Raquel
Mellor Pita, Susana Teresa
Tutor de Ureta, Pablo
Durán del Campo, Pedro
Martinez Urbistondo, Maria
Vazquez Comendador, José
Gutierrez Rojas, Ángela
Rosado, Silvia
Vargas Núñez, Juan Antonio
author_role author
author2 Castejon, Raquel
Mellor Pita, Susana Teresa
Tutor de Ureta, Pablo
Durán del Campo, Pedro
Martinez Urbistondo, Maria
Vazquez Comendador, José
Gutierrez Rojas, Ángela
Rosado, Silvia
Vargas Núñez, Juan Antonio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv IL-6
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
red blood cell distribution width
systemic lupus erythematosus
Medicina
topic IL-6
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
red blood cell distribution width
systemic lupus erythematosus
Medicina
description Background and objectives: Systemic Lupus Erythematosus (SLE) follow-up is based on clinical, and analytical parameters. We aimed to determine the differences between the Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR) and Red blood cell distribution width (RDW) between SLE patients and healthy controls and to assess their association with anemia status, classical inflammatory biomarkers and cytokines, disease activity, SLE related factors and treatment received for SLE. Methods: Seventy-seven patients with SLE according to 2012 SLICC criteria and 80 healthy controls were included. Patients with SLE were classified in SLE with anemia (SLE-a) and SLE without anemia (SLE-na). Statistical analysis between SLE patients and controls and the association of serological and clinical activity markers with proposed hematological indices among SLE patients were performed. Results: RDW, NLR and PLR, were significantly higher in SLE patients than in healthy control group (p < 0.001), in SLE-a patients as compared to SLE-na (p < 0.0001) and were significantly associated with hypocomplementemia (p < 0.05). PLR was higher in active patients measured by SLEDAI-2K score and with longer disease duration (p < 0.05). RDW was associated with serological activity of the patients (p < 0.05) and was correlated with SLEDAI-2K and SLICC/ACR scores, hsCRP, D-dimer, fibrinogen, IL-6 and TNF as well as with corticosteroids intake (p = 0.05). A logistic regression analysis confirmed that after adjustment by age and hemoglobin values, RDW presented linear correlation with IL-6 levels (Beta-coefficient = 0.369, p = 0.003). Conclusion: NLR, PLR and RDW values suggest SLE serological and clinical activity. Given their availability, these markers not only could be useful tools to identify and monitor active SLE patients but whose application should be considered in inflammatory pathologies orchestrated by IL-6 and TNF
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/713898
https://dx.doi.org/10.1016/j.jtauto.2022.100157
url http://hdl.handle.net/10486/713898
https://dx.doi.org/10.1016/j.jtauto.2022.100157
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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