Early origin and evolution of the FtsZ/tubulin protein family

The origin of the FtsZ/tubulin protein family was extremely relevant for life since these proteins are present in nearly all organisms, carrying out essential functions such as cell division or forming a major part of the cytoskeleton in eukaryotes. Therefore, investigating the early evolution of th...

Descripción completa

Detalles Bibliográficos
Autores: Santana-Molina, Carlos, Saz-Navarro, María del, Devos, Damien P.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/336904
Acceso en línea:http://hdl.handle.net/10261/336904
Access Level:acceso abierto
Palabra clave:FtsZ
Tubulin
CetZ
Evolution
Tree of life
id ES_d6b23fed9f45c3b652b99dfea46eae3e
oai_identifier_str oai:digital.csic.es:10261/336904
network_acronym_str ES
network_name_str España
repository_id_str
spelling Early origin and evolution of the FtsZ/tubulin protein familySantana-Molina, CarlosSaz-Navarro, María delDevos, Damien P.FtsZTubulinCetZEvolutionTree of lifeThe origin of the FtsZ/tubulin protein family was extremely relevant for life since these proteins are present in nearly all organisms, carrying out essential functions such as cell division or forming a major part of the cytoskeleton in eukaryotes. Therefore, investigating the early evolution of the FtsZ/tubulin protein family could reveal crucial aspects of the diversification of the three domains of life. In this study, we revisited the phylogenies of the FtsZ/tubulin protein family in an extensive prokaryotic diversity, focusing on the main evolutionary events that occurred during its evolution. We found evidence of its early origin in the last universal common ancestor since FtsZ was present in the last common ancestor of Bacteria and Archaea. In bacteria, ftsZ genes are genomically associated with the bacterial division gene cluster, while in archaea, ftsZ duplicated prior to archaeal diversification, and one of the copies is associated with protein biosynthesis genes. Archaea have expanded the FtsZ/tubulin protein family with sequences closely related to eukaryotic tubulins. In addition, we report novel CetZ-like groups in Halobacterota and Asgardarchaeota. Investigating the C-termini of prokaryotic paralogs basal to eukaryotic tubulins, we show that archaeal CetZ, as well as the plasmidic TubZ from Firmicutes, most likely originated from archaeal FtsZ. Finally, prokaryotic tubulins are restricted to Odinarchaeaota and Prosthecobacter species, and they seem to belong to different molecular systems. However, their phylogenies suggest that they are closely related to α/β-tubulins pointing to a potential ancestrality of these eukaryotic paralogs of tubulins.This publication was funded in part by the Gordon and Betty Moore Foundation through Grant GBMF9733 and by the Spanish Ministry of Economy and Competitiveness (Grant No. BFU2016-78326-P) to DD.Peer reviewedFrontiers MediaGordon and Betty Moore FoundationMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/336904reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//BFU2016-78326-PSantana-Molina, Carlos; Saz-Navarro, María del; Devos, Damien P.; 2023; Data_Sheet_1_Early origin and evolution of the FtsZ/tubulin protein family.PDF; Frontiers Media; https://doi.org/10.3389/fmicb.2022.1100249.s001Santana-Molina, Carlos; Saz-Navarro, María del; Devos, Damien P.; 2023; Data_Sheet_2_Early origin and evolution of the FtsZ/tubulin protein family.ZIP; Frontiers Media; https://doi.org/10.3389/fmicb.2022.1100249.s002http://dx.doi.org/10.3389/fmicb.2022.1100249Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3369042026-05-22T06:33:51Z
dc.title.none.fl_str_mv Early origin and evolution of the FtsZ/tubulin protein family
title Early origin and evolution of the FtsZ/tubulin protein family
spellingShingle Early origin and evolution of the FtsZ/tubulin protein family
Santana-Molina, Carlos
FtsZ
Tubulin
CetZ
Evolution
Tree of life
title_short Early origin and evolution of the FtsZ/tubulin protein family
title_full Early origin and evolution of the FtsZ/tubulin protein family
title_fullStr Early origin and evolution of the FtsZ/tubulin protein family
title_full_unstemmed Early origin and evolution of the FtsZ/tubulin protein family
title_sort Early origin and evolution of the FtsZ/tubulin protein family
dc.creator.none.fl_str_mv Santana-Molina, Carlos
Saz-Navarro, María del
Devos, Damien P.
author Santana-Molina, Carlos
author_facet Santana-Molina, Carlos
Saz-Navarro, María del
Devos, Damien P.
author_role author
author2 Saz-Navarro, María del
Devos, Damien P.
author2_role author
author
dc.contributor.none.fl_str_mv Gordon and Betty Moore Foundation
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv FtsZ
Tubulin
CetZ
Evolution
Tree of life
topic FtsZ
Tubulin
CetZ
Evolution
Tree of life
description The origin of the FtsZ/tubulin protein family was extremely relevant for life since these proteins are present in nearly all organisms, carrying out essential functions such as cell division or forming a major part of the cytoskeleton in eukaryotes. Therefore, investigating the early evolution of the FtsZ/tubulin protein family could reveal crucial aspects of the diversification of the three domains of life. In this study, we revisited the phylogenies of the FtsZ/tubulin protein family in an extensive prokaryotic diversity, focusing on the main evolutionary events that occurred during its evolution. We found evidence of its early origin in the last universal common ancestor since FtsZ was present in the last common ancestor of Bacteria and Archaea. In bacteria, ftsZ genes are genomically associated with the bacterial division gene cluster, while in archaea, ftsZ duplicated prior to archaeal diversification, and one of the copies is associated with protein biosynthesis genes. Archaea have expanded the FtsZ/tubulin protein family with sequences closely related to eukaryotic tubulins. In addition, we report novel CetZ-like groups in Halobacterota and Asgardarchaeota. Investigating the C-termini of prokaryotic paralogs basal to eukaryotic tubulins, we show that archaeal CetZ, as well as the plasmidic TubZ from Firmicutes, most likely originated from archaeal FtsZ. Finally, prokaryotic tubulins are restricted to Odinarchaeaota and Prosthecobacter species, and they seem to belong to different molecular systems. However, their phylogenies suggest that they are closely related to α/β-tubulins pointing to a potential ancestrality of these eukaryotic paralogs of tubulins.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/336904
url http://hdl.handle.net/10261/336904
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//BFU2016-78326-P
Santana-Molina, Carlos; Saz-Navarro, María del; Devos, Damien P.; 2023; Data_Sheet_1_Early origin and evolution of the FtsZ/tubulin protein family.PDF; Frontiers Media; https://doi.org/10.3389/fmicb.2022.1100249.s001
Santana-Molina, Carlos; Saz-Navarro, María del; Devos, Damien P.; 2023; Data_Sheet_2_Early origin and evolution of the FtsZ/tubulin protein family.ZIP; Frontiers Media; https://doi.org/10.3389/fmicb.2022.1100249.s002
http://dx.doi.org/10.3389/fmicb.2022.1100249
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420906307125248
score 15.81155

Similares en LA Referencia