Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings

During the last decade, there has been a tremendous interest for developing non-natural biocompatible transformations in biologically relevant media. Among the different encountered strategies, the use of transition metal complexes offers unique possibilities due to their high transformative power....

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Detalles Bibliográficos
Autores: Destito, Paolo, Vidal, Cristian, López, Fernando, Mascareñas, José L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/257969
Acceso en línea:http://hdl.handle.net/10261/257969
Access Level:acceso abierto
Palabra clave:Biological chemistry
Organometallic catalysis
Biocatalysis
Cellular chemistry
Aqueous catalysis
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spelling Transition Metal-Promoted Reactions in Aqueous Media and Biological SettingsDestito, PaoloVidal, CristianLópez, FernandoMascareñas, José L.Biological chemistryOrganometallic catalysisBiocatalysisCellular chemistryAqueous catalysisDuring the last decade, there has been a tremendous interest for developing non-natural biocompatible transformations in biologically relevant media. Among the different encountered strategies, the use of transition metal complexes offers unique possibilities due to their high transformative power. However, translating the potential of metal catalysts to biological settings, including living cells or small-animal models such as mice or zebrafish, poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Herein, we describe the most relevant advances in this direction, with a particular emphasis on the systems’ structure, their mode of action and the mechanistic bases of each transformation. Thus, the key challenges from an organometallic perspective might be more easily identified.We would like to acknowledge financial support from Spanish grants (SAF2016-76689-R, CTQ2017-84767-P and ORFEO- CINQA network CTQ2016-81797-REDC), the Consellería de Cultura, Educación e Ordenación Universitaria (2015-CP082, ED431C-2017/19 and Centro Singular de Investigación de Galicia accreditation 2019-2022, ED431G 2019/03), the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financial framework 2014-2020), and the European Research Council (Advanced Grant No. 340055). DFF thanks Xunta de Galicia for his postdoctoral fellowship (ED481B- 2019-005). C.V. thank the Ministerio de Economía y Competividad for the Juan de la Cierva-Formación fellowship (FJCI-2017-33168).John Wiley & SonsXunta de GaliciaEuropean CommissionMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/257969reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1002/chem.202003927Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2579692026-05-22T06:33:51Z
dc.title.none.fl_str_mv Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings
title Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings
spellingShingle Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings
Destito, Paolo
Biological chemistry
Organometallic catalysis
Biocatalysis
Cellular chemistry
Aqueous catalysis
title_short Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings
title_full Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings
title_fullStr Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings
title_full_unstemmed Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings
title_sort Transition Metal-Promoted Reactions in Aqueous Media and Biological Settings
dc.creator.none.fl_str_mv Destito, Paolo
Vidal, Cristian
López, Fernando
Mascareñas, José L.
author Destito, Paolo
author_facet Destito, Paolo
Vidal, Cristian
López, Fernando
Mascareñas, José L.
author_role author
author2 Vidal, Cristian
López, Fernando
Mascareñas, José L.
author2_role author
author
author
dc.contributor.none.fl_str_mv Xunta de Galicia
European Commission
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Biological chemistry
Organometallic catalysis
Biocatalysis
Cellular chemistry
Aqueous catalysis
topic Biological chemistry
Organometallic catalysis
Biocatalysis
Cellular chemistry
Aqueous catalysis
description During the last decade, there has been a tremendous interest for developing non-natural biocompatible transformations in biologically relevant media. Among the different encountered strategies, the use of transition metal complexes offers unique possibilities due to their high transformative power. However, translating the potential of metal catalysts to biological settings, including living cells or small-animal models such as mice or zebrafish, poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Herein, we describe the most relevant advances in this direction, with a particular emphasis on the systems’ structure, their mode of action and the mechanistic bases of each transformation. Thus, the key challenges from an organometallic perspective might be more easily identified.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/257969
url http://hdl.handle.net/10261/257969
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1002/chem.202003927
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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