Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.

Castro Grattoni, Anabel L.; Torres Cortada, Gerard; Martínez Alonso, Montserrat; Barbé Illa, Ferran; Turino, Cecilia; Sánchez de la Torre, Alicia; Cortijo, Anunciación; Duran Cantolla, Joaquin; Egea, Carlos; Cao, Gonzalo; Sánchez de la Torre, Manuel

Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.

The reduction in blood pressure (BP) with continuous positive airway pressure (CPAP) is modest and highly variable. In this study, we identified the variables that predict BP response to CPAP.24-h ambulatory BP monitoring (ABPM), C-reactive protein (CRP), leptin, adiponectin and 24-h urinary catecho...

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Autores:	Castro Grattoni, Anabel L., Torres Cortada, Gerard, Martínez Alonso, Montserrat, Barbé Illa, Ferran, Turino, Cecilia, Sánchez de la Torre, Alicia, Cortijo, Anunciación, Duran Cantolla, Joaquin, Egea, Carlos, Cao, Gonzalo, Sánchez de la Torre, Manuel
Tipo de recurso:	artículo
Fecha de publicación:	2017
País:	España
Institución:	Universidad de Castilla-La Mancha
Repositorio:	RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:	oai:ruidera.uclm.es:10578/41109
Acceso en línea:	http://europepmc.org/abstract/med/28982776 https://hdl.handle.net/10578/41109
Access Level:	acceso abierto
Palabra clave:	24-h ambulatory blood pressure monitoring Blood pressure Continuous positive airway pressure Hypertension Obstructive sleep apnoea

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spelling	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.Castro Grattoni, Anabel L.Torres Cortada, GerardMartínez Alonso, MontserratBarbé Illa, FerranTurino, CeciliaSánchez de la Torre, AliciaCortijo, AnunciaciónDuran Cantolla, JoaquinEgea, CarlosCao, GonzaloSánchez de la Torre, Manuel24-h ambulatory blood pressure monitoringBlood pressureContinuous positive airway pressureHypertensionObstructive sleep apnoeaThe reduction in blood pressure (BP) with continuous positive airway pressure (CPAP) is modest and highly variable. In this study, we identified the variables that predict BP response to CPAP.24-h ambulatory BP monitoring (ABPM), C-reactive protein (CRP), leptin, adiponectin and 24-h urinary catecholamine were measured before and after 6 months of CPAP in obstructive sleep apnoea (OSA) patients.Overall, 88 middle-aged, obese male patients with severe OSA (median apnoea-hypopnoea index 42 events·h-1) were included; 28.4% had hypertension. 62 patients finished the study, and 60 were analysed. The daytime diastolic BP (-2 mmHg) and norepinephrine (-109.5 nmol·day-1) were reduced after CPAP, but no changes in the 24-h BP, night-time BP, dopamine, epinephrine, CRP, leptin or adiponectin were detected. The nocturnal normotension was associated with an increased night-time-BP (+4 mmHg) after CPAP, whereas nocturnal hypertension was associated with a reduction of 24-h BP (-3 mmHg). A multivariate linear regression model showed differential night-time BP changes after CPAP. Specifically, low night-time heart rate (<68 bpm) and BP dipper profile were associated with increased night-time BP and new diagnosis of nocturnal hypertension.Our results suggest that nocturnal hypertension, circadian BP pattern and night-time heart rate could be clinical predictors of BP response to CPAP and support the usefulness of 24-h ABPM for OSA patients before treatment initiation. These results need to be confirmed in further studies.ERS202520252017info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://europepmc.org/abstract/med/28982776https://hdl.handle.net/10578/41109reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/411092026-05-27T07:36:41Z
dc.title.none.fl_str_mv	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.
title	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.
spellingShingle	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring. Castro Grattoni, Anabel L. 24-h ambulatory blood pressure monitoring Blood pressure Continuous positive airway pressure Hypertension Obstructive sleep apnoea
title_short	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.
title_full	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.
title_fullStr	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.
title_full_unstemmed	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.
title_sort	Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.
dc.creator.none.fl_str_mv	Castro Grattoni, Anabel L. Torres Cortada, Gerard Martínez Alonso, Montserrat Barbé Illa, Ferran Turino, Cecilia Sánchez de la Torre, Alicia Cortijo, Anunciación Duran Cantolla, Joaquin Egea, Carlos Cao, Gonzalo Sánchez de la Torre, Manuel
author	Castro Grattoni, Anabel L.
author_facet	Castro Grattoni, Anabel L. Torres Cortada, Gerard Martínez Alonso, Montserrat Barbé Illa, Ferran Turino, Cecilia Sánchez de la Torre, Alicia Cortijo, Anunciación Duran Cantolla, Joaquin Egea, Carlos Cao, Gonzalo Sánchez de la Torre, Manuel
author_role	author
author2	Torres Cortada, Gerard Martínez Alonso, Montserrat Barbé Illa, Ferran Turino, Cecilia Sánchez de la Torre, Alicia Cortijo, Anunciación Duran Cantolla, Joaquin Egea, Carlos Cao, Gonzalo Sánchez de la Torre, Manuel
author2_role	author author author author author author author author author author
dc.subject.none.fl_str_mv	24-h ambulatory blood pressure monitoring Blood pressure Continuous positive airway pressure Hypertension Obstructive sleep apnoea
topic	24-h ambulatory blood pressure monitoring Blood pressure Continuous positive airway pressure Hypertension Obstructive sleep apnoea
description	The reduction in blood pressure (BP) with continuous positive airway pressure (CPAP) is modest and highly variable. In this study, we identified the variables that predict BP response to CPAP.24-h ambulatory BP monitoring (ABPM), C-reactive protein (CRP), leptin, adiponectin and 24-h urinary catecholamine were measured before and after 6 months of CPAP in obstructive sleep apnoea (OSA) patients.Overall, 88 middle-aged, obese male patients with severe OSA (median apnoea-hypopnoea index 42 events·h-1) were included; 28.4% had hypertension. 62 patients finished the study, and 60 were analysed. The daytime diastolic BP (-2 mmHg) and norepinephrine (-109.5 nmol·day-1) were reduced after CPAP, but no changes in the 24-h BP, night-time BP, dopamine, epinephrine, CRP, leptin or adiponectin were detected. The nocturnal normotension was associated with an increased night-time-BP (+4 mmHg) after CPAP, whereas nocturnal hypertension was associated with a reduction of 24-h BP (-3 mmHg). A multivariate linear regression model showed differential night-time BP changes after CPAP. Specifically, low night-time heart rate (<68 bpm) and BP dipper profile were associated with increased night-time BP and new diagnosis of nocturnal hypertension.Our results suggest that nocturnal hypertension, circadian BP pattern and night-time heart rate could be clinical predictors of BP response to CPAP and support the usefulness of 24-h ABPM for OSA patients before treatment initiation. These results need to be confirmed in further studies.
publishDate	2017
dc.date.none.fl_str_mv	2017 2025 2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://europepmc.org/abstract/med/28982776 https://hdl.handle.net/10578/41109
url	http://europepmc.org/abstract/med/28982776 https://hdl.handle.net/10578/41109
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	ERS
publisher.none.fl_str_mv	ERS
dc.source.none.fl_str_mv	reponame:RUIdeRA. Repositorio Institucional de la UCLM instname:Universidad de Castilla-La Mancha
instname_str	Universidad de Castilla-La Mancha
reponame_str	RUIdeRA. Repositorio Institucional de la UCLM
collection	RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring.

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