Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene
It is becoming increasingly clear that the activation of specific terminal differentiation genes during neural development is critically dependent upon the establishment of unique combinatorial transcription factor codes within distinct neural cell subtypes. However, it is still unclear to which ext...
| Autores: | , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2010 |
| País: | España |
| Recursos: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/660506 |
| Acesso em linha: | http://hdl.handle.net/10486/660506 https://dx.doi.org/10.1016/j.mod.2010.08.003 |
| Access Level: | acceso abierto |
| Palavra-chave: | Drosophila Terminal differentiation Combinatorial code Neuropeptidergic cell identity Temporal genes FMRFa Biología y Biomedicina / Biología |
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Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation geneLosada-Pérez, MaríaGabilondo, HugoSaz, Delia delBaumgardt, MagnusMolina Balsa, IsabelLeón Álvarez, YolandaMonedero Cobeta, IgnacioDíaz-Benjumea, FernandoTorroja Fungairiño, LauraBenito Sipos, JonathanDrosophilaTerminal differentiationCombinatorial codeNeuropeptidergic cell identityTemporal genesFMRFaBiología y Biomedicina / BiologíaIt is becoming increasingly clear that the activation of specific terminal differentiation genes during neural development is critically dependent upon the establishment of unique combinatorial transcription factor codes within distinct neural cell subtypes. However, it is still unclear to which extent these codes are shared by lineage-unrelated neurons expressing the same terminal differentiation genes. Additionally, it is not known if the activation of a specific terminal differentiation gene is restricted to cells born at a particular developmental time point. Here, we utilize the terminal differentiation gene FMRFa which is expressed by the Ap4 and SE2 neurons in the Drosophila ventral nerve cord, to explore these issues in depth. We find that the Ap4 and SE2 neurons are generated by different neural progenitors and use different combinatorial codes to activate FMRFa expression. Additionally, we find that the Ap4 and SE2 neurons are generated in different temporal gene expression windows. Extending the investigation to include a second Drosophila terminal differentiation gene, Leucokinin, we find similar results, suggesting that neurons generated by different progenitors might commonly use different transcription factor codes to activate the same terminal differentiation gene. Furthermore, these results imply that the activation of a particular terminal differentiation gene in temporally unrestricted.This work was supported by a grant from the Spanish Ministerio de Ciencia e Innovación (BFU-2008- 04683-C02-02 to L.T.).Elsevier ScientificDepartamento de BiologíaFacultad de Ciencias20102010-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/660506https://dx.doi.org/10.1016/j.mod.2010.08.003reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6605062026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene |
| title |
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene |
| spellingShingle |
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene Losada-Pérez, María Drosophila Terminal differentiation Combinatorial code Neuropeptidergic cell identity Temporal genes FMRFa Biología y Biomedicina / Biología |
| title_short |
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene |
| title_full |
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene |
| title_fullStr |
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene |
| title_full_unstemmed |
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene |
| title_sort |
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene |
| dc.creator.none.fl_str_mv |
Losada-Pérez, María Gabilondo, Hugo Saz, Delia del Baumgardt, Magnus Molina Balsa, Isabel León Álvarez, Yolanda Monedero Cobeta, Ignacio Díaz-Benjumea, Fernando Torroja Fungairiño, Laura Benito Sipos, Jonathan |
| author |
Losada-Pérez, María |
| author_facet |
Losada-Pérez, María Gabilondo, Hugo Saz, Delia del Baumgardt, Magnus Molina Balsa, Isabel León Álvarez, Yolanda Monedero Cobeta, Ignacio Díaz-Benjumea, Fernando Torroja Fungairiño, Laura Benito Sipos, Jonathan |
| author_role |
author |
| author2 |
Gabilondo, Hugo Saz, Delia del Baumgardt, Magnus Molina Balsa, Isabel León Álvarez, Yolanda Monedero Cobeta, Ignacio Díaz-Benjumea, Fernando Torroja Fungairiño, Laura Benito Sipos, Jonathan |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Biología Facultad de Ciencias |
| dc.subject.none.fl_str_mv |
Drosophila Terminal differentiation Combinatorial code Neuropeptidergic cell identity Temporal genes FMRFa Biología y Biomedicina / Biología |
| topic |
Drosophila Terminal differentiation Combinatorial code Neuropeptidergic cell identity Temporal genes FMRFa Biología y Biomedicina / Biología |
| description |
It is becoming increasingly clear that the activation of specific terminal differentiation genes during neural development is critically dependent upon the establishment of unique combinatorial transcription factor codes within distinct neural cell subtypes. However, it is still unclear to which extent these codes are shared by lineage-unrelated neurons expressing the same terminal differentiation genes. Additionally, it is not known if the activation of a specific terminal differentiation gene is restricted to cells born at a particular developmental time point. Here, we utilize the terminal differentiation gene FMRFa which is expressed by the Ap4 and SE2 neurons in the Drosophila ventral nerve cord, to explore these issues in depth. We find that the Ap4 and SE2 neurons are generated by different neural progenitors and use different combinatorial codes to activate FMRFa expression. Additionally, we find that the Ap4 and SE2 neurons are generated in different temporal gene expression windows. Extending the investigation to include a second Drosophila terminal differentiation gene, Leucokinin, we find similar results, suggesting that neurons generated by different progenitors might commonly use different transcription factor codes to activate the same terminal differentiation gene. Furthermore, these results imply that the activation of a particular terminal differentiation gene in temporally unrestricted. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010 2010-01-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/660506 https://dx.doi.org/10.1016/j.mod.2010.08.003 |
| url |
http://hdl.handle.net/10486/660506 https://dx.doi.org/10.1016/j.mod.2010.08.003 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier Scientific |
| publisher.none.fl_str_mv |
Elsevier Scientific |
| dc.source.none.fl_str_mv |
reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
| reponame_str |
Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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1869420892439707648 |
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15,300724 |