Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes

© The Author(s) 2018.

Detalles Bibliográficos
Autores: Royall, Amy H., Maeso, Ignacio, Dunwell, Thomas L., Holland, Peter W. H.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/242392
Acceso en línea:http://hdl.handle.net/10261/242392
Access Level:acceso abierto
Palabra clave:Gene duplication
Gene loss
Homeodomain
PRD class
ARGFX
Transcription factors
Compensation
Blastocyst
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spelling Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genesRoyall, Amy H.Maeso, IgnacioDunwell, Thomas L.Holland, Peter W. H.Gene duplicationGene lossHomeodomainPRD classARGFXTranscription factorsCompensationBlastocyst© The Author(s) 2018.[Background]: ETCHbox genes are eutherian-specific homeobox genes expressed during preimplantation development at a time when the first cell lineage decisions are being made. The mouse has an unusual repertoire of ETCHbox genes with several gene families lost in evolution and the remaining two, Crxos and Obox, greatly divergent in sequence and number. Each has undergone duplication to give a double homeodomain Crxos locus and a large cluster of over 60 Obox loci. The gene content differences between species raise important questions about how evolution can tolerate loss of genes implicated in key developmental events.[Results]: We find that Crxos internal duplication occurred in the mouse lineage, while Obox duplication was stepwise, generating subgroups with distinct sequence and expression. Ectopic expression of three Obox genes and a Crxos transcript in primary mouse embryonic cells followed by transcriptome sequencing allowed investigation into their functional roles. We find distinct transcriptomic influences for different Obox subgroups and Crxos, including modulation of genes related to zygotic genome activation and preparation for blastocyst formation. Comparison with similar experiments performed using human homeobox genes reveals striking overlap between genes downstream of mouse Crxos and genes downstream of human ARGFX.[Conclusions]: Mouse Crxos and human ARGFX homeobox genes are paralogous rather than orthologous, yet they have evolved to regulate a common set of genes. This suggests there was compensation of function alongside gene loss through co-option of a different locus. Functional compensation by non-orthologous genes with dissimilar sequences is unusual but may indicate underlying distributed robustness. Compensation may be driven by the strong evolutionary pressure for successful early embryo development.Funding was provided through the Oxford Interdisciplinary Bioscience BBSRC Doctoral Training Partnership (BB/M011224/1), the EPA Cephalosporin Fund and a Royal Society International Exchanges Grant.BioMed CentralUniversity of OxfordRoyal Society (UK)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120182021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/242392reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1186/s13227-018-0091-4Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2423922026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
title Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
spellingShingle Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
Royall, Amy H.
Gene duplication
Gene loss
Homeodomain
PRD class
ARGFX
Transcription factors
Compensation
Blastocyst
title_short Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
title_full Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
title_fullStr Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
title_full_unstemmed Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
title_sort Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
dc.creator.none.fl_str_mv Royall, Amy H.
Maeso, Ignacio
Dunwell, Thomas L.
Holland, Peter W. H.
author Royall, Amy H.
author_facet Royall, Amy H.
Maeso, Ignacio
Dunwell, Thomas L.
Holland, Peter W. H.
author_role author
author2 Maeso, Ignacio
Dunwell, Thomas L.
Holland, Peter W. H.
author2_role author
author
author
dc.contributor.none.fl_str_mv University of Oxford
Royal Society (UK)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gene duplication
Gene loss
Homeodomain
PRD class
ARGFX
Transcription factors
Compensation
Blastocyst
topic Gene duplication
Gene loss
Homeodomain
PRD class
ARGFX
Transcription factors
Compensation
Blastocyst
description © The Author(s) 2018.
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/242392
url http://hdl.handle.net/10261/242392
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1186/s13227-018-0091-4
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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