Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats

Rationale and objectives Pain sensation can negatively impact cognitive function, including impulsivity. Pain-induced changes in impulsivity can contribute to development of psychiatric comorbidities found in those with chronic pain conditions. The goal of this study was to determine whether complet...

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Detalles Bibliográficos
Autores: Espinoza Serrano, Nidia, Saputra, Samuel G., Company, Matthew, Nazarian, Arbi, Ibias Martín, Javier
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Nacional de Educación a Distancia
Repositorio:e-spacio. Repositorio Institucional de la UNED
Idioma:inglés
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/12623
Acceso en línea:https://hdl.handle.net/20.500.14468/12623
Access Level:acceso abierto
Palabra clave:Delay discounting
Opioid
Impulsivity
Pain
Sex difference
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spelling Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in ratsEspinoza Serrano, NidiaSaputra, Samuel G.Company, MatthewNazarian, ArbiIbias Martín, JavierDelay discountingOpioidImpulsivityPainSex differenceRationale and objectives Pain sensation can negatively impact cognitive function, including impulsivity. Pain-induced changes in impulsivity can contribute to development of psychiatric comorbidities found in those with chronic pain conditions. The goal of this study was to determine whether complete Freund’s adjuvant (CFA)-induced pain manipulation enhances impulsivity in rats. Whether the pain-induced impulsivity is sexually dimorphic, and if mu-opioid receptors play a role in these processes. Methods Male and female rats were screened for trait impulsivity and designated as high or low impulsive using a delay discounting task. Rats then received a hind paw injection of CFA, and their impulsivity was assessed for 16 days. The effects of morphine on impulsivity were also examined. In a separate experiment, rats were pretreated with beta-funaltrexamine (β-FNA) to determine the role of mu-opioid receptors on impulsivity. Results CFA treatment increased impulsivity in males and females. The onset of CFA-induced impulsivity was faster in high impulsive females than males. Morphine blocked CFA-induced impulsivity in both sexes in a dose- and time-dependent manner. β-FNA prevented the actions of morphine on CFA-induced impulsivity in high impulsive males, but not high impulsive females. Moreover, β-FNA increased CFA-induced impulsivity in morphine naïve males, but not females. Conclusion These findings demonstrate unique sex differences in CFA-induced impulsivity, response to morphine, and the impact of mu-opioid receptors. A better understanding of cognitive deficits and their mechanisms can provide insight into the development of substance abuse and psychiatric comorbidities that occur in people with chronic pain.Springer Naturee-Spacio UNED20242024-05-2020212021-08-2420212021-08-24journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/12623reponame:e-spacio. Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/126232026-06-06T12:38:31Z
dc.title.none.fl_str_mv Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
title Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
spellingShingle Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
Espinoza Serrano, Nidia
Delay discounting
Opioid
Impulsivity
Pain
Sex difference
title_short Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
title_full Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
title_fullStr Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
title_full_unstemmed Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
title_sort Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
dc.creator.none.fl_str_mv Espinoza Serrano, Nidia
Saputra, Samuel G.
Company, Matthew
Nazarian, Arbi
Ibias Martín, Javier
author Espinoza Serrano, Nidia
author_facet Espinoza Serrano, Nidia
Saputra, Samuel G.
Company, Matthew
Nazarian, Arbi
Ibias Martín, Javier
author_role author
author2 Saputra, Samuel G.
Company, Matthew
Nazarian, Arbi
Ibias Martín, Javier
author2_role author
author
author
author
dc.contributor.none.fl_str_mv e-Spacio UNED
dc.subject.none.fl_str_mv Delay discounting
Opioid
Impulsivity
Pain
Sex difference
topic Delay discounting
Opioid
Impulsivity
Pain
Sex difference
description Rationale and objectives Pain sensation can negatively impact cognitive function, including impulsivity. Pain-induced changes in impulsivity can contribute to development of psychiatric comorbidities found in those with chronic pain conditions. The goal of this study was to determine whether complete Freund’s adjuvant (CFA)-induced pain manipulation enhances impulsivity in rats. Whether the pain-induced impulsivity is sexually dimorphic, and if mu-opioid receptors play a role in these processes. Methods Male and female rats were screened for trait impulsivity and designated as high or low impulsive using a delay discounting task. Rats then received a hind paw injection of CFA, and their impulsivity was assessed for 16 days. The effects of morphine on impulsivity were also examined. In a separate experiment, rats were pretreated with beta-funaltrexamine (β-FNA) to determine the role of mu-opioid receptors on impulsivity. Results CFA treatment increased impulsivity in males and females. The onset of CFA-induced impulsivity was faster in high impulsive females than males. Morphine blocked CFA-induced impulsivity in both sexes in a dose- and time-dependent manner. β-FNA prevented the actions of morphine on CFA-induced impulsivity in high impulsive males, but not high impulsive females. Moreover, β-FNA increased CFA-induced impulsivity in morphine naïve males, but not females. Conclusion These findings demonstrate unique sex differences in CFA-induced impulsivity, response to morphine, and the impact of mu-opioid receptors. A better understanding of cognitive deficits and their mechanisms can provide insight into the development of substance abuse and psychiatric comorbidities that occur in people with chronic pain.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-08-24
2021
2021-08-24
2024
2024-05-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14468/12623
url https://hdl.handle.net/20.500.14468/12623
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:e-spacio. Repositorio Institucional de la UNED
instname:Universidad Nacional de Educación a Distancia
instname_str Universidad Nacional de Educación a Distancia
reponame_str e-spacio. Repositorio Institucional de la UNED
collection e-spacio. Repositorio Institucional de la UNED
repository.name.fl_str_mv
repository.mail.fl_str_mv
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