Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Myocardial ischemia (MI) remains one of the leading causes of death worldwide. Angiogenic therapy with the vascular endothelial growth factor (VEGF) is a promising strategy to overcome hypoxia and its consequences. However, from the clinical data it is clear that fulfillment of the potential of VEGF...

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Autores: Simon-Yarza, T. (Teresa)|||/items/8bf17254-4031-4c72-9a3a-9622a60c311f, Tamayo, E. (Esther)|||/items/10d4cc56-0128-4842-a5fc-2585a32f1e9f, Benavides, C. (Carolina)|||/items/f16b873e-c02f-4920-a7a9-26c08e5b6368, Lana, H. (Hugo)|||/items/e924cc6a-f04d-44a0-bc6f-194223a1ecf1, Formiga, F.R. (Fabio R.)|||/items/ac4aaf2f-6636-445b-943e-2bb14ad3e326, Grama, C.R. (Charitra N.)|||/items/5ad1bf34-e718-4c7e-9ffa-6a1717b0eb2e, Ortiz-de-Solorzano, C. (Carlos)|||/items/b2c0bd13-68a7-437c-b67f-2e5f1a9f0324, Ravi-Kumar, M.N.V. (M.N.V.)|||/items/10dedbf0-eedf-489a-81d9-6ff44482b3bc, Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1, Blanco-Prieto, M.J. (María José)|||/items/93e177db-635f-456f-b672-b79ef8befc40
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/36746
Acceso en línea:https://hdl.handle.net/10171/36746
Access Level:acceso abierto
Palabra clave:VEGF
CoQ10
Protein delivery
Angiogenesis
Tissue engineering
Myocardial ischemia
Descripción
Sumario:Myocardial ischemia (MI) remains one of the leading causes of death worldwide. Angiogenic therapy with the vascular endothelial growth factor (VEGF) is a promising strategy to overcome hypoxia and its consequences. However, from the clinical data it is clear that fulfillment of the potential of VEGF warrants a better delivery strategy. On the other hand, the compelling evidences of the role of oxidative stress in diseases like MI encourage the use of antioxidant agents. Coenzyme Q10 (CoQ10) due to its role in the electron transport chain in the mitochondria seems to be a good candidate to manage MI but is associated with poor biopharmaceutical properties seeking better delivery approaches. The female Sprague Dawley rats were induced MI and were followed up with VEGF microparticles intramyocardially and CoQ10 nanoparticles orally or their combination with appropriate controls. Cardiac function was assessed by measuring ejection fraction before and after three months of therapy. Results demonstrate significant improvement in the ejection fraction after three months with both treatment forms individually; however the combination therapy failed to offer any synergism. In conclusion, VEGF microparticles and CoQ10 nanoparticles can be considered as promising strategies for managing MI.

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