Effect and Metabolism of lignans on gut microbiota and their impact on health

The World Health Organization (WHO) 1 says that CVDs are number one cause of death globally. An estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths. Over three quarters of CVD deaths take place in low- and middle-income countries. Some of the risk factors are...

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Autor: Creus i Cuadros, Anna
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/553245
Acceso en línea:http://hdl.handle.net/10803/553245
Access Level:acceso abierto
Palabra clave:Malalties cardiovasculars
Enfermedades cardiovasculares
Cardiovascular diseases
Malnutrició
Malnutrición
Malnutrition
Microbiota
Polifenols
Polifenoles
Polyphenols
Ciències de la Salut
615
id ES_d61fd9cc8bc278efe4e0262d2acde306
oai_identifier_str oai:www.tdx.cat:10803/553245
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Effect and Metabolism of lignans on gut microbiota and their impact on health
title Effect and Metabolism of lignans on gut microbiota and their impact on health
spellingShingle Effect and Metabolism of lignans on gut microbiota and their impact on health
Creus i Cuadros, Anna
Malalties cardiovasculars
Enfermedades cardiovasculares
Cardiovascular diseases
Malnutrició
Malnutrición
Malnutrition
Microbiota
Polifenols
Polifenoles
Polyphenols
Ciències de la Salut
615
title_short Effect and Metabolism of lignans on gut microbiota and their impact on health
title_full Effect and Metabolism of lignans on gut microbiota and their impact on health
title_fullStr Effect and Metabolism of lignans on gut microbiota and their impact on health
title_full_unstemmed Effect and Metabolism of lignans on gut microbiota and their impact on health
title_sort Effect and Metabolism of lignans on gut microbiota and their impact on health
dc.creator.none.fl_str_mv Creus i Cuadros, Anna
author Creus i Cuadros, Anna
author_facet Creus i Cuadros, Anna
author_role author
dc.contributor.none.fl_str_mv Lamuela Raventós, Rosa Ma.
Casals i Ribes, Isidre
Lamuela Raventós, Rosa Ma.
Universitat de Barcelona. Facultat de Farmàcia i Ciències de l'Alimentació
dc.subject.none.fl_str_mv Malalties cardiovasculars
Enfermedades cardiovasculares
Cardiovascular diseases
Malnutrició
Malnutrición
Malnutrition
Microbiota
Polifenols
Polifenoles
Polyphenols
Ciències de la Salut
615
topic Malalties cardiovasculars
Enfermedades cardiovasculares
Cardiovascular diseases
Malnutrició
Malnutrición
Malnutrition
Microbiota
Polifenols
Polifenoles
Polyphenols
Ciències de la Salut
615
description The World Health Organization (WHO) 1 says that CVDs are number one cause of death globally. An estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths. Over three quarters of CVD deaths take place in low- and middle-income countries. Some of the risk factors are raised blood pressure, raised blood glucose, raised blood lipids, and overweight and obesity. A large number of epidemiological studies have associated the consumption of polyphenols with a decreased risk of CV or coronary heart disease. Lignans are a class of polyphenols formed by 2 phenylpropane units, also referred as plant phytoestrogens. When ingested, they can be metabolized by the gastrointestinal microbiota to their bioactive forms, the enterolignans enterodiol (ED) and enterolactone (EL)2,3 . The presence of ED and EL in the body has been correlated with the prevention of some chronic disease like cardiovascular disease, osteoporosis, and hyperlipidemia, and some cancers like colon cancer, breast cancer, prostate cancer and menopausal syndrome2,4,5. Moreover, since in the last consensus International Scientific Association for Probiotics and Prebiotics (ISAPP) concluded that plant polyphenols can also meet the criteria of prebiotics; lignans could act as a prebiotic. Although, still more studies in the target host are required6. Malnutrition is estimated to contribute to more than one third of all child deaths, although it is rarely listed as the direct cause7. From WHO sources7 we know that in 2014, approximately 462 million adults worldwide were underweight, while 1.9 billion were either overweight or obese. In 2016, an estimated 155 million children under the age of 5 years were suffering from stunting, while 41 million were overweight or obese. Around 45% of deaths among children under 5 years of age are linked to undernutrition. These mostly occur in low- and middle-income countries. At the same time, in these same countries, rates of childhood overweight and obesity are rising. It is becoming increasingly apparent that gut microbiota play a pivotal role in the development and etiology of malnutrition8–10. The microbiota influence host metabolism, nutrient absorption, inflammation and even hormonal signaling, leading to changes in linear growth and weight gain in mice and humans11,12. In this thesis I aim to study the impact of dietary lignans and yogurts on cardiovascular risk parameters, deepen on knowledge of lignans metabolism by gut microbiota and evaluate the impact of lignans in health and malnourishment.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2019
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/553245
url http://hdl.handle.net/10803/553245
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 208 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
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spelling Effect and Metabolism of lignans on gut microbiota and their impact on healthCreus i Cuadros, AnnaMalalties cardiovascularsEnfermedades cardiovascularesCardiovascular diseasesMalnutricióMalnutriciónMalnutritionMicrobiotaPolifenolsPolifenolesPolyphenolsCiències de la Salut615The World Health Organization (WHO) 1 says that CVDs are number one cause of death globally. An estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths. Over three quarters of CVD deaths take place in low- and middle-income countries. Some of the risk factors are raised blood pressure, raised blood glucose, raised blood lipids, and overweight and obesity. A large number of epidemiological studies have associated the consumption of polyphenols with a decreased risk of CV or coronary heart disease. Lignans are a class of polyphenols formed by 2 phenylpropane units, also referred as plant phytoestrogens. When ingested, they can be metabolized by the gastrointestinal microbiota to their bioactive forms, the enterolignans enterodiol (ED) and enterolactone (EL)2,3 . The presence of ED and EL in the body has been correlated with the prevention of some chronic disease like cardiovascular disease, osteoporosis, and hyperlipidemia, and some cancers like colon cancer, breast cancer, prostate cancer and menopausal syndrome2,4,5. Moreover, since in the last consensus International Scientific Association for Probiotics and Prebiotics (ISAPP) concluded that plant polyphenols can also meet the criteria of prebiotics; lignans could act as a prebiotic. Although, still more studies in the target host are required6. Malnutrition is estimated to contribute to more than one third of all child deaths, although it is rarely listed as the direct cause7. From WHO sources7 we know that in 2014, approximately 462 million adults worldwide were underweight, while 1.9 billion were either overweight or obese. In 2016, an estimated 155 million children under the age of 5 years were suffering from stunting, while 41 million were overweight or obese. Around 45% of deaths among children under 5 years of age are linked to undernutrition. These mostly occur in low- and middle-income countries. At the same time, in these same countries, rates of childhood overweight and obesity are rising. It is becoming increasingly apparent that gut microbiota play a pivotal role in the development and etiology of malnutrition8–10. The microbiota influence host metabolism, nutrient absorption, inflammation and even hormonal signaling, leading to changes in linear growth and weight gain in mice and humans11,12. In this thesis I aim to study the impact of dietary lignans and yogurts on cardiovascular risk parameters, deepen on knowledge of lignans metabolism by gut microbiota and evaluate the impact of lignans in health and malnourishment.Universitat de BarcelonaLamuela Raventós, Rosa Ma.Casals i Ribes, IsidreLamuela Raventós, Rosa Ma.Universitat de Barcelona. Facultat de Farmàcia i Ciències de l'Alimentació201820192018info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion208 p.application/pdfapplication/pdfhttp://hdl.handle.net/10803/553245TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésADVERTIMENT. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/5532452026-06-14T12:46:07Z
score 15,301603

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