Human studies carried out with pomegranate-based products (juice and extract)

The consumption of pomegranate juices and extracts has long been linked to many health benefits beyond nutrition, described mainly by innumerable preclinical studies. However, the European Food Safety Authority (EFSA) concluded in 2010 that a cause and effect relationship could not be established be...

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Autores: Giménez-Bastida, J. A., Ávila-Gálvez, María Ángeles, Espín de Gea, Juan Carlos, González-Sarrías, Antonio
Tipo de recurso: conjunto de datos
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/285785
Acceso en línea:http://hdl.handle.net/10261/285785
Access Level:acceso abierto
Palabra clave:Punica granatum
Clinical trials
Microbial Metabolites
Cardiovascular
EFSA
Polyphenols
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spelling Human studies carried out with pomegranate-based products (juice and extract)Giménez-Bastida, J. A.Ávila-Gálvez, María ÁngelesEspín de Gea, Juan CarlosGonzález-Sarrías, AntonioPunica granatumClinical trialsMicrobial MetabolitesCardiovascularEFSAPolyphenolsThe consumption of pomegranate juices and extracts has long been linked to many health benefits beyond nutrition, described mainly by innumerable preclinical studies. However, the European Food Safety Authority (EFSA) concluded in 2010 that a cause and effect relationship could not be established between the consumption of pomegranate-derived products and all the health claims presented. There are no additional EFSA opinions on health claims specifically addressed to pomegranate in the last decade. Scope and approach This review comprehensively compiles all human studies conducted on pomegranate. The aim is to discuss these studies critically to identify possible flaws and propose guidelines that might help establish a cause and effect relationship between pomegranate-derived product consumption and health. Key findings and conclusions To date, 86 human studies have evaluated the health benefits of pomegranate juices and extracts. The most promising, albeit scarce, evidence is related to blood pressure improvement. Less evidence deals with inflammation, cancer, cognitive function, physical activity, and gut microbiota modulation (prebiotic effects). After a decade since EFSA's opinion, human evidence remains inconsistent, making it difficult to support most claimed health effects. The lack of effects and(or) data discrepancy might be attributable to design limitations, including insufficient product characterization and interindividual variability that influence pomegranate polyphenols' bioefficacy. New coordinated strategies between policy makers, research/academic institutions, and industry are needed to move forward. Therefore, this review presents a roadmap to conduct well-designed trials and cover existing gaps, which could establish a cause-effect relation between pomegranate consumption and health benefits beyond nutrition.European Commission: PolyBiota - Polyphenols and Gut Microbiota interaction in Cardiovascular Health (838991)Peer reviewedZenodoEuropean CommissionGiménez-Bastida, J. A. [0000-0002-1244-8764]Ávila-Gálvez, María Ángeles [0000-0003-2513-1026]Espín de Gea, Juan Carlos [0000-0002-1068-8692]González-Sarrías, Antonio [0000-0002-3407-0678]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1application/pdfhttp://hdl.handle.net/10261/285785reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/838991Juan Antonio Giménez-Bastida; María ÁngelesÁvila-Gálvez; Juan Carlos Espín; Antonio González Sarrías; Evidence for health properties of pomegranate juices and extracts beyond nutrition: A critical systematic review of human studies, Trends in Food Science & Technology, Volume 114, 2021, Pages 410-423; ISSN 0924-2244; https://doi.org/10.1016/j.tifs.2021.06.014; http://hdl.handle.net/10261/251962https://doi.org/10.5281/zenodo.7261732Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2857852026-05-22T06:33:51Z
dc.title.none.fl_str_mv Human studies carried out with pomegranate-based products (juice and extract)
title Human studies carried out with pomegranate-based products (juice and extract)
spellingShingle Human studies carried out with pomegranate-based products (juice and extract)
Giménez-Bastida, J. A.
Punica granatum
Clinical trials
Microbial Metabolites
Cardiovascular
EFSA
Polyphenols
title_short Human studies carried out with pomegranate-based products (juice and extract)
title_full Human studies carried out with pomegranate-based products (juice and extract)
title_fullStr Human studies carried out with pomegranate-based products (juice and extract)
title_full_unstemmed Human studies carried out with pomegranate-based products (juice and extract)
title_sort Human studies carried out with pomegranate-based products (juice and extract)
dc.creator.none.fl_str_mv Giménez-Bastida, J. A.
Ávila-Gálvez, María Ángeles
Espín de Gea, Juan Carlos
González-Sarrías, Antonio
author Giménez-Bastida, J. A.
author_facet Giménez-Bastida, J. A.
Ávila-Gálvez, María Ángeles
Espín de Gea, Juan Carlos
González-Sarrías, Antonio
author_role author
author2 Ávila-Gálvez, María Ángeles
Espín de Gea, Juan Carlos
González-Sarrías, Antonio
author2_role author
author
author
dc.contributor.none.fl_str_mv European Commission
Giménez-Bastida, J. A. [0000-0002-1244-8764]
Ávila-Gálvez, María Ángeles [0000-0003-2513-1026]
Espín de Gea, Juan Carlos [0000-0002-1068-8692]
González-Sarrías, Antonio [0000-0002-3407-0678]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Punica granatum
Clinical trials
Microbial Metabolites
Cardiovascular
EFSA
Polyphenols
topic Punica granatum
Clinical trials
Microbial Metabolites
Cardiovascular
EFSA
Polyphenols
description The consumption of pomegranate juices and extracts has long been linked to many health benefits beyond nutrition, described mainly by innumerable preclinical studies. However, the European Food Safety Authority (EFSA) concluded in 2010 that a cause and effect relationship could not be established between the consumption of pomegranate-derived products and all the health claims presented. There are no additional EFSA opinions on health claims specifically addressed to pomegranate in the last decade. Scope and approach This review comprehensively compiles all human studies conducted on pomegranate. The aim is to discuss these studies critically to identify possible flaws and propose guidelines that might help establish a cause and effect relationship between pomegranate-derived product consumption and health. Key findings and conclusions To date, 86 human studies have evaluated the health benefits of pomegranate juices and extracts. The most promising, albeit scarce, evidence is related to blood pressure improvement. Less evidence deals with inflammation, cancer, cognitive function, physical activity, and gut microbiota modulation (prebiotic effects). After a decade since EFSA's opinion, human evidence remains inconsistent, making it difficult to support most claimed health effects. The lack of effects and(or) data discrepancy might be attributable to design limitations, including insufficient product characterization and interindividual variability that influence pomegranate polyphenols' bioefficacy. New coordinated strategies between policy makers, research/academic institutions, and industry are needed to move forward. Therefore, this review presents a roadmap to conduct well-designed trials and cover existing gaps, which could establish a cause-effect relation between pomegranate consumption and health benefits beyond nutrition.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/285785
url http://hdl.handle.net/10261/285785
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/838991
Juan Antonio Giménez-Bastida; María ÁngelesÁvila-Gálvez; Juan Carlos Espín; Antonio González Sarrías; Evidence for health properties of pomegranate juices and extracts beyond nutrition: A critical systematic review of human studies, Trends in Food Science & Technology, Volume 114, 2021, Pages 410-423; ISSN 0924-2244; https://doi.org/10.1016/j.tifs.2021.06.014; http://hdl.handle.net/10261/251962
https://doi.org/10.5281/zenodo.7261732
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Zenodo
publisher.none.fl_str_mv Zenodo
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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