Age protects from harmful effects produced by chronic intermittent hypoxia

Producción Científica

Detalles Bibliográficos
Autores: Quintero Coca, Miguel, Olea Fraile, Elena, Conde, Silvia V., Gallego Martín, María Teresa, González Martínez, Constancio, Montserrat, Josep M., Gómez Niño, María Ángeles, Yubero Benito, Sara, Agapito Serrano, María Teresa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/46963
Acceso en línea:https://doi.org/10.1113/JP270878
https://uvadoc.uva.es/handle/10324/46963
Access Level:acceso abierto
Palabra clave:Intermittent hypoxia
Hipoxia intermitente
Sleep apnoea
Apnea del sueño
id ES_d5eb931e88cfc2bb29ad520c8d93e70c
oai_identifier_str oai:uvadoc.uva.es:10324/46963
network_acronym_str ES
network_name_str España
repository_id_str
spelling Age protects from harmful effects produced by chronic intermittent hypoxiaQuintero Coca, MiguelOlea Fraile, ElenaConde, Silvia V.Gallego Martín, María TeresaGonzález Martínez, ConstancioMontserrat, Josep M.Gómez Niño, María ÁngelesYubero Benito, SaraAgapito Serrano, María TeresaIntermittent hypoxiaHipoxia intermitenteSleep apnoeaApnea del sueñoProducción CientíficaObstructive sleep apnoea (OSA) affects an estimated 3–7% of the adult population, the frequency doubling at ages >60–65 years. As it evolves, OSA becomes frequently associated with cardiovascular, metabolic and neuropsychiatric pathologies defining OSA syndrome (OSAS). Exposing experimental animals to chronic intermittent hypoxia (CIH) can be used as a model of the recurrent hypoxic and O2 desaturation patterns observed in OSA patients. CIH is an important OSA event triggering associated pathologies; CIH induces carotid body (CB)-driven exaggerated sympathetic tone and overproduction of reactive oxygen species, related to the pathogenic mechanisms of associated pathologies observed in OSAS. Aiming to discover why OSAS is clinically less conspicuous in aged patients, the present study compares CIH effects in young (3–4 months) and aged (22–24 months) rats. To define potential distinctive patterns of these pathogenic mechanisms, mean arterial blood pressure as the final CIH outcome was measured. In young rats, CIH augmented CB sensory responses to hypoxia, decreased hypoxic ventilation and augmented sympathetic activity (plasma catecholamine levels and renal artery content and synthesis rate). An increased brainstem integration of CB sensory input as a trigger of sympathetic activity is suggested. CIH also caused an oxidative status decreasing aconitase/fumarase ratio and superoxide dismutase activity. In aged animals, CIH minimally affected CB responses, ventilation and sympathetic-related parameters leaving redox status unaltered. In young animals, CIH caused hypertension and in aged animals, whose baseline blood pressure was augmented, CIH did not augment it further. Plausible mechanisms of the differences and potential significance of these findings for the diagnosis and therapy of OSAS are discussed.Ministerio de Ciencia, Innovación y Universidades (grant BFU2012-37459)Instituto de Salud Carlos III (grant CIBER CB06/06/0050)Portuguese Foundation for Science and Technology (grant EXP/NEU-SCC/2813/2013)The Physiological Society2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1113/JP270878https://uvadoc.uva.es/handle/10324/46963reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP270878info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/469632026-06-13T12:44:47Z
dc.title.none.fl_str_mv Age protects from harmful effects produced by chronic intermittent hypoxia
title Age protects from harmful effects produced by chronic intermittent hypoxia
spellingShingle Age protects from harmful effects produced by chronic intermittent hypoxia
Quintero Coca, Miguel
Intermittent hypoxia
Hipoxia intermitente
Sleep apnoea
Apnea del sueño
title_short Age protects from harmful effects produced by chronic intermittent hypoxia
title_full Age protects from harmful effects produced by chronic intermittent hypoxia
title_fullStr Age protects from harmful effects produced by chronic intermittent hypoxia
title_full_unstemmed Age protects from harmful effects produced by chronic intermittent hypoxia
title_sort Age protects from harmful effects produced by chronic intermittent hypoxia
dc.creator.none.fl_str_mv Quintero Coca, Miguel
Olea Fraile, Elena
Conde, Silvia V.
Gallego Martín, María Teresa
González Martínez, Constancio
Montserrat, Josep M.
Gómez Niño, María Ángeles
Yubero Benito, Sara
Agapito Serrano, María Teresa
author Quintero Coca, Miguel
author_facet Quintero Coca, Miguel
Olea Fraile, Elena
Conde, Silvia V.
Gallego Martín, María Teresa
González Martínez, Constancio
Montserrat, Josep M.
Gómez Niño, María Ángeles
Yubero Benito, Sara
Agapito Serrano, María Teresa
author_role author
author2 Olea Fraile, Elena
Conde, Silvia V.
Gallego Martín, María Teresa
González Martínez, Constancio
Montserrat, Josep M.
Gómez Niño, María Ángeles
Yubero Benito, Sara
Agapito Serrano, María Teresa
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Intermittent hypoxia
Hipoxia intermitente
Sleep apnoea
Apnea del sueño
topic Intermittent hypoxia
Hipoxia intermitente
Sleep apnoea
Apnea del sueño
description Producción Científica
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1113/JP270878
https://uvadoc.uva.es/handle/10324/46963
url https://doi.org/10.1113/JP270878
https://uvadoc.uva.es/handle/10324/46963
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP270878
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Physiological Society
publisher.none.fl_str_mv The Physiological Society
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420768038748160
score 15.300719

Similares en LA Referencia