The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus

Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, but also pathophysiological processes, which include inflammation, pain and fever. They are produced by almost all cell types in the organism by activation of Prostaglandin endo...

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Autores: Martín Vázquez, Eugenia, Cobo Vuilleumier, Nadia, López Noriega, Livia, Lorenzo, Petra I., Gauthier, Benoit R.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/160474
Acceso en línea:https://hdl.handle.net/11441/160474
https://doi.org/10.7150/ijbs.86492
Access Level:acceso abierto
Palabra clave:Beta cells
Cyclooxygenases
Inflammation
Pancreatic Islets
Prostaglandin
Type 1 Diabetes Mellitus
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spelling The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes MellitusMartín Vázquez, EugeniaCobo Vuilleumier, NadiaLópez Noriega, LiviaLorenzo, Petra I.Gauthier, Benoit R.Beta cellsCyclooxygenasesInflammationPancreatic IsletsProstaglandinType 1 Diabetes MellitusProstaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, but also pathophysiological processes, which include inflammation, pain and fever. They are produced by almost all cell types in the organism by activation of Prostaglandin endoperoxide synthases/Cyclooxygenases. The inducible Prostaglandin Endoperoxide Synthase 2/Cyclooxygenase 2 (PTGS2/COX2) plays an important role in pathologies associated with inflammatory signaling. The main product derived from PTGS2/COX2 expression and activation is Prostaglandin E2 (PGE2), which promotes a wide variety of tissue-specific effects, pending environmental inputs. One of the major sources of PGE2 are infiltrating inflammatory cells - the production of this molecule increases drastically in damaged tissues. Immune infiltration is a hallmark of type 1 diabetes mellitus, a multifactorial disease that leads to autoimmune-mediated pancreatic beta cell destruction. Controversial effects for the PTGS2/COX2-PGE2 signaling cascade in pancreatic islet cells subjected to diabetogenic conditions have been reported, allocating PGE2 as both, cause and consequence of inflammation. Herein, we review the main effects of this molecular pathway in a tissue-specific manner, with a special emphasis on beta cell mass protection/destruction and its potential role in the prevention or development of T1DM. We also discuss strategies to target this pathway for future therapies.Junta de Andalucía PI-0727-2010, PI-0085-2013Ministerio de Ciencia e Innovación P10.CTS.6359, DOC_00652, PI10/00871, PI13/00593 , BFU2017- 83588-P, PID2021-123083NB-I00, PRE2018-084907Juvenile Diabetes Research Foundation 17-2013-372, 2-SRA-2019-837-S-B, 3-SRA-2023-1307-S-BIvyspring International PublisherBiología CelularJunta de AndalucíaMinisterio de Ciencia e Innovación (MICIN). EspañaJuvenile Diabetes Research Foundation. USA2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/160474https://doi.org/10.7150/ijbs.86492reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Biological Sciences, 19 (13), 4157-4165.PI-0727-2010PI-0085-2013P10.CTS.6359DOC_00652PI10/00871BFU2017- 83588-PPID2021-123083NB-I00PRE2018-08490717-2013-3722-SRA-2019-837-S-B3-SRA-2023-1307-S-Bhttps://dx.doi.org/10.7150/ijbs.86492info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1604742026-06-17T12:51:07Z
dc.title.none.fl_str_mv The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
title The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
spellingShingle The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
Martín Vázquez, Eugenia
Beta cells
Cyclooxygenases
Inflammation
Pancreatic Islets
Prostaglandin
Type 1 Diabetes Mellitus
title_short The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
title_full The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
title_fullStr The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
title_full_unstemmed The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
title_sort The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
dc.creator.none.fl_str_mv Martín Vázquez, Eugenia
Cobo Vuilleumier, Nadia
López Noriega, Livia
Lorenzo, Petra I.
Gauthier, Benoit R.
author Martín Vázquez, Eugenia
author_facet Martín Vázquez, Eugenia
Cobo Vuilleumier, Nadia
López Noriega, Livia
Lorenzo, Petra I.
Gauthier, Benoit R.
author_role author
author2 Cobo Vuilleumier, Nadia
López Noriega, Livia
Lorenzo, Petra I.
Gauthier, Benoit R.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Biología Celular
Junta de Andalucía
Ministerio de Ciencia e Innovación (MICIN). España
Juvenile Diabetes Research Foundation. USA
dc.subject.none.fl_str_mv Beta cells
Cyclooxygenases
Inflammation
Pancreatic Islets
Prostaglandin
Type 1 Diabetes Mellitus
topic Beta cells
Cyclooxygenases
Inflammation
Pancreatic Islets
Prostaglandin
Type 1 Diabetes Mellitus
description Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, but also pathophysiological processes, which include inflammation, pain and fever. They are produced by almost all cell types in the organism by activation of Prostaglandin endoperoxide synthases/Cyclooxygenases. The inducible Prostaglandin Endoperoxide Synthase 2/Cyclooxygenase 2 (PTGS2/COX2) plays an important role in pathologies associated with inflammatory signaling. The main product derived from PTGS2/COX2 expression and activation is Prostaglandin E2 (PGE2), which promotes a wide variety of tissue-specific effects, pending environmental inputs. One of the major sources of PGE2 are infiltrating inflammatory cells - the production of this molecule increases drastically in damaged tissues. Immune infiltration is a hallmark of type 1 diabetes mellitus, a multifactorial disease that leads to autoimmune-mediated pancreatic beta cell destruction. Controversial effects for the PTGS2/COX2-PGE2 signaling cascade in pancreatic islet cells subjected to diabetogenic conditions have been reported, allocating PGE2 as both, cause and consequence of inflammation. Herein, we review the main effects of this molecular pathway in a tissue-specific manner, with a special emphasis on beta cell mass protection/destruction and its potential role in the prevention or development of T1DM. We also discuss strategies to target this pathway for future therapies.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/160474
https://doi.org/10.7150/ijbs.86492
url https://hdl.handle.net/11441/160474
https://doi.org/10.7150/ijbs.86492
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Biological Sciences, 19 (13), 4157-4165.
PI-0727-2010
PI-0085-2013
P10.CTS.6359
DOC_00652
PI10/00871
BFU2017- 83588-P
PID2021-123083NB-I00
PRE2018-084907
17-2013-372
2-SRA-2019-837-S-B
3-SRA-2023-1307-S-B
https://dx.doi.org/10.7150/ijbs.86492
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Ivyspring International Publisher
publisher.none.fl_str_mv Ivyspring International Publisher
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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