Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray...

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Autores: Urretavizcaya Sarachaga, Mikel, Soriano Mas, Carles, Menchón Magriñá, José Manuel, Global ECT-MRI Research Collaboration (GEMRIC)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/173248
Acceso en línea:https://hdl.handle.net/2445/173248
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Cervell
Biochemical markers
Brain
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spelling Brain Changes Induced by Electroconvulsive Therapy Are Broadly DistributedUrretavizcaya Sarachaga, MikelSoriano Mas, CarlesMenchón Magriñá, José ManuelGlobal ECT-MRI Research Collaboration (GEMRIC)Marcadors bioquímicsCervellBiochemical markersBrainBACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean +/- SD of 1.04 +/- 1.03% (Cohen's d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 +/- 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation rho = -.44, p < .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.Elsevier Science Inc.2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/173248Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.biopsych.2019.07.010Biological Psychiatry, 2020, vol. 87, num. 5, p. 451-461https://doi.org/10.1016/j.biopsych.2019.07.010cc by-nc-nd (c) Society of Biological Psychiatry, 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1732482026-05-27T06:46:51Z
dc.title.none.fl_str_mv Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
spellingShingle Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
Urretavizcaya Sarachaga, Mikel
Marcadors bioquímics
Cervell
Biochemical markers
Brain
title_short Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title_full Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title_fullStr Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title_full_unstemmed Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title_sort Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
dc.creator.none.fl_str_mv Urretavizcaya Sarachaga, Mikel
Soriano Mas, Carles
Menchón Magriñá, José Manuel
Global ECT-MRI Research Collaboration (GEMRIC)
author Urretavizcaya Sarachaga, Mikel
author_facet Urretavizcaya Sarachaga, Mikel
Soriano Mas, Carles
Menchón Magriñá, José Manuel
Global ECT-MRI Research Collaboration (GEMRIC)
author_role author
author2 Soriano Mas, Carles
Menchón Magriñá, José Manuel
Global ECT-MRI Research Collaboration (GEMRIC)
author2_role author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Cervell
Biochemical markers
Brain
topic Marcadors bioquímics
Cervell
Biochemical markers
Brain
description BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean +/- SD of 1.04 +/- 1.03% (Cohen's d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 +/- 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation rho = -.44, p < .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173248
url https://hdl.handle.net/2445/173248
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.biopsych.2019.07.010
Biological Psychiatry, 2020, vol. 87, num. 5, p. 451-461
https://doi.org/10.1016/j.biopsych.2019.07.010
dc.rights.none.fl_str_mv cc by-nc-nd (c) Society of Biological Psychiatry, 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Society of Biological Psychiatry, 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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