Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing

3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emergin...

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Autores: Rodríguez Pombo, Lucía, Martínez Castro, Laura, Xu, Xiaoyan, Ong, Jun Jie, Rial, Carlos, García, Daniel Nieto, González Santos, Alejandro, Flores González, Julián Carlos, Álvarez Lorenzo, Carmen, Basit, Abdul W., Goyanes Goyanes, Álvaro
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/43319
Acceso en línea:https://hdl.handle.net/10347/43319
Access Level:acceso abierto
Palabra clave:Vat photopolymerization 3D printed medicines
3D rotary printing
Tomographic reconstruction
3D printed drug products
Printing pharmaceuticals and drug delivery systems
Personalized formulations
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spelling Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printingRodríguez Pombo, LucíaMartínez Castro, LauraXu, XiaoyanOng, Jun JieRial, CarlosGarcía, Daniel NietoGonzález Santos, AlejandroFlores González, Julián CarlosÁlvarez Lorenzo, CarmenBasit, Abdul W.Goyanes Goyanes, ÁlvaroVat photopolymerization 3D printed medicines3D rotary printingTomographic reconstruction3D printed drug productsPrinting pharmaceuticals and drug delivery systemsPersonalized formulations3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry.ElsevierUniversidade de Santiago de Compostela. Centro de Investigación en Tecnoloxías Intelixentes da USC (CiTIUS)Universidade de Santiago de Compostela. Departamento de Farmacia e Tecnoloxía FarmacéuticaUniversidade de Santiago de Compostela. Instituto de Materiais (iMATUS)20232023-02-1520232023-02-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/43319reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-113881RB-I00open accesshttp://purl.org/coar/access_right/c_abf2© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/433192026-06-15T12:47:27Z
dc.title.none.fl_str_mv Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
spellingShingle Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
Rodríguez Pombo, Lucía
Vat photopolymerization 3D printed medicines
3D rotary printing
Tomographic reconstruction
3D printed drug products
Printing pharmaceuticals and drug delivery systems
Personalized formulations
title_short Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_full Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_fullStr Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_full_unstemmed Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_sort Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
dc.creator.none.fl_str_mv Rodríguez Pombo, Lucía
Martínez Castro, Laura
Xu, Xiaoyan
Ong, Jun Jie
Rial, Carlos
García, Daniel Nieto
González Santos, Alejandro
Flores González, Julián Carlos
Álvarez Lorenzo, Carmen
Basit, Abdul W.
Goyanes Goyanes, Álvaro
author Rodríguez Pombo, Lucía
author_facet Rodríguez Pombo, Lucía
Martínez Castro, Laura
Xu, Xiaoyan
Ong, Jun Jie
Rial, Carlos
García, Daniel Nieto
González Santos, Alejandro
Flores González, Julián Carlos
Álvarez Lorenzo, Carmen
Basit, Abdul W.
Goyanes Goyanes, Álvaro
author_role author
author2 Martínez Castro, Laura
Xu, Xiaoyan
Ong, Jun Jie
Rial, Carlos
García, Daniel Nieto
González Santos, Alejandro
Flores González, Julián Carlos
Álvarez Lorenzo, Carmen
Basit, Abdul W.
Goyanes Goyanes, Álvaro
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Centro de Investigación en Tecnoloxías Intelixentes da USC (CiTIUS)
Universidade de Santiago de Compostela. Departamento de Farmacia e Tecnoloxía Farmacéutica
Universidade de Santiago de Compostela. Instituto de Materiais (iMATUS)
dc.subject.none.fl_str_mv Vat photopolymerization 3D printed medicines
3D rotary printing
Tomographic reconstruction
3D printed drug products
Printing pharmaceuticals and drug delivery systems
Personalized formulations
topic Vat photopolymerization 3D printed medicines
3D rotary printing
Tomographic reconstruction
3D printed drug products
Printing pharmaceuticals and drug delivery systems
Personalized formulations
description 3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-02-15
2023
2023-02-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/43319
url https://hdl.handle.net/10347/43319
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-113881RB-I00
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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