Leishmania Hijacks myeloid cells for immune escape

Protozoan parasites of the Leishmania genus are the causative agents of leishmaniasis, a group of neglected tropical diseases whose clinical manifestations vary depending on the infectious Leishmania species but also on host factors. Recognition of the parasite by host myeloid immune cells is a key...

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Autores: Martínez-López, María, Soto, Manuel, Iborra, Salvador, Sancho, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/179513
Acceso en línea:http://hdl.handle.net/10261/179513
Access Level:acceso abierto
Palabra clave:Dendritic cells
Macrophages
Neutrophils
Immune escape
Leishmania
Myeloid cell
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spelling Leishmania Hijacks myeloid cells for immune escapeMartínez-López, MaríaSoto, ManuelIborra, SalvadorSancho, DavidDendritic cellsMacrophagesNeutrophilsImmune escapeLeishmaniaMyeloid cellProtozoan parasites of the Leishmania genus are the causative agents of leishmaniasis, a group of neglected tropical diseases whose clinical manifestations vary depending on the infectious Leishmania species but also on host factors. Recognition of the parasite by host myeloid immune cells is a key to trigger an effective Leishmania-specific immunity. However, the parasite is able to persist in host myeloid cells by evading, delaying and manipulating host immunity in order to escape host resistance and ensure its transmission. Neutrophils are first in infiltrating infection sites and could act either favoring or protecting against infection, depending on factors such as the genetic background of the host or the parasite species. Macrophages are the main host cells where the parasites grow and divide. However, macrophages are also the main effector population involved in parasite clearance. Parasite elimination by macrophages requires the priming and development of an effector Th1 adaptive immunity driven by specific subtypes of dendritic cells. Herein, we will provide a comprehensive outline of how myeloid cells regulate innate and adaptive immunity against Leishmania, and the mechanisms used by the parasites to promote their evasion and sabotage. Understanding the interactions between Leishmania and the host myeloid cells may lead to the development of new therapeutic approaches and improved vaccination to leishmaniases, an important worldwide health problem in which current therapeutic or preventive approaches are limited.Ministry of Economy, Industry and Competitiveness (MINECO) and FEDER (European Fund for Regional Development). MM-Lreceived a FPU fellowship (AP2010-5935) from the Spanish Ministry of Education; Comunidad de Madrid; RD16/0015/0018-REEM from FIS-Instituto de Salud Carlos III, MINECO and FEDER; Acteria Foundation; Constantes y vitales prize (Atresmedia); La Marató de TV3 Foundation (201723); the European CommissionPeer ReviewedPremios constantes y vitales (España)Fundació La Marató de TV3Fondation ActeriaMinisterio de Educación (Ecuador)Ministerio de Economía, Industria y Competitividad (España)European CommissionInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920182019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/179513reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1795132026-05-22T06:33:51Z
dc.title.none.fl_str_mv Leishmania Hijacks myeloid cells for immune escape
title Leishmania Hijacks myeloid cells for immune escape
spellingShingle Leishmania Hijacks myeloid cells for immune escape
Martínez-López, María
Dendritic cells
Macrophages
Neutrophils
Immune escape
Leishmania
Myeloid cell
title_short Leishmania Hijacks myeloid cells for immune escape
title_full Leishmania Hijacks myeloid cells for immune escape
title_fullStr Leishmania Hijacks myeloid cells for immune escape
title_full_unstemmed Leishmania Hijacks myeloid cells for immune escape
title_sort Leishmania Hijacks myeloid cells for immune escape
dc.creator.none.fl_str_mv Martínez-López, María
Soto, Manuel
Iborra, Salvador
Sancho, David
author Martínez-López, María
author_facet Martínez-López, María
Soto, Manuel
Iborra, Salvador
Sancho, David
author_role author
author2 Soto, Manuel
Iborra, Salvador
Sancho, David
author2_role author
author
author
dc.contributor.none.fl_str_mv Premios constantes y vitales (España)
Fundació La Marató de TV3
Fondation Acteria
Ministerio de Educación (Ecuador)
Ministerio de Economía, Industria y Competitividad (España)
European Commission
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Dendritic cells
Macrophages
Neutrophils
Immune escape
Leishmania
Myeloid cell
topic Dendritic cells
Macrophages
Neutrophils
Immune escape
Leishmania
Myeloid cell
description Protozoan parasites of the Leishmania genus are the causative agents of leishmaniasis, a group of neglected tropical diseases whose clinical manifestations vary depending on the infectious Leishmania species but also on host factors. Recognition of the parasite by host myeloid immune cells is a key to trigger an effective Leishmania-specific immunity. However, the parasite is able to persist in host myeloid cells by evading, delaying and manipulating host immunity in order to escape host resistance and ensure its transmission. Neutrophils are first in infiltrating infection sites and could act either favoring or protecting against infection, depending on factors such as the genetic background of the host or the parasite species. Macrophages are the main host cells where the parasites grow and divide. However, macrophages are also the main effector population involved in parasite clearance. Parasite elimination by macrophages requires the priming and development of an effector Th1 adaptive immunity driven by specific subtypes of dendritic cells. Herein, we will provide a comprehensive outline of how myeloid cells regulate innate and adaptive immunity against Leishmania, and the mechanisms used by the parasites to promote their evasion and sabotage. Understanding the interactions between Leishmania and the host myeloid cells may lead to the development of new therapeutic approaches and improved vaccination to leishmaniases, an important worldwide health problem in which current therapeutic or preventive approaches are limited.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/179513
url http://hdl.handle.net/10261/179513
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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