GPCR photopharmacology

New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light...

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Detalhes bibliográficos
Autores: Ricart-Ortega, María, Font, Joan, Llebaria, Amadeu
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/201805
Acesso em linha:http://hdl.handle.net/10261/201805
Access Level:acceso abierto
Palavra-chave:Caged compounds
G protein-coupled receptors
Photochromic ligands
Photopharmacology
Photoswitchable orthogonal remotely tethered ligands
Photoswitchable tethered ligands
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spelling GPCR photopharmacologyRicart-Ortega, MaríaFont, JoanLlebaria, AmadeuCaged compoundsG protein-coupled receptorsPhotochromic ligandsPhotopharmacologyPhotoswitchable orthogonal remotely tethered ligandsPhotoswitchable tethered ligandsNew technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved. In this context, the use of light provides an advantage as it combines safety, easy delivery, high resolution and it does not interfere with most cellular processes. In this review we summarize the most relevant successful achievements in GPCR photopharmacology. These recent findings constitute a significant advance in research studies on the molecular dynamics of receptor activation and their physiological roles in vivo. Moreover, these molecules hold potential toward clinical uses as light-operated drugs, which can overcome some of the problems of conventional pharmacology. © 2019 Elsevier B.V.We acknowledge financial support from the ERANET Neuron LIGHTPAIN and MAGNOLIA projects, the Spanish Ministry of Science, Innovation and Universities (CTQ2014-57020-R and CTQ2017-89222-R), cofinanced by the European Regional Development Fund and the Catalan Government (2017SGR01604).Peer reviewedElsevierLlebaría, Amadeu [0000-0002-8200-4827]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/201805reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.mce.2019.03.003Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2018052026-05-22T06:33:51Z
dc.title.none.fl_str_mv GPCR photopharmacology
title GPCR photopharmacology
spellingShingle GPCR photopharmacology
Ricart-Ortega, María
Caged compounds
G protein-coupled receptors
Photochromic ligands
Photopharmacology
Photoswitchable orthogonal remotely tethered ligands
Photoswitchable tethered ligands
title_short GPCR photopharmacology
title_full GPCR photopharmacology
title_fullStr GPCR photopharmacology
title_full_unstemmed GPCR photopharmacology
title_sort GPCR photopharmacology
dc.creator.none.fl_str_mv Ricart-Ortega, María
Font, Joan
Llebaria, Amadeu
author Ricart-Ortega, María
author_facet Ricart-Ortega, María
Font, Joan
Llebaria, Amadeu
author_role author
author2 Font, Joan
Llebaria, Amadeu
author2_role author
author
dc.contributor.none.fl_str_mv Llebaría, Amadeu [0000-0002-8200-4827]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Caged compounds
G protein-coupled receptors
Photochromic ligands
Photopharmacology
Photoswitchable orthogonal remotely tethered ligands
Photoswitchable tethered ligands
topic Caged compounds
G protein-coupled receptors
Photochromic ligands
Photopharmacology
Photoswitchable orthogonal remotely tethered ligands
Photoswitchable tethered ligands
description New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved. In this context, the use of light provides an advantage as it combines safety, easy delivery, high resolution and it does not interfere with most cellular processes. In this review we summarize the most relevant successful achievements in GPCR photopharmacology. These recent findings constitute a significant advance in research studies on the molecular dynamics of receptor activation and their physiological roles in vivo. Moreover, these molecules hold potential toward clinical uses as light-operated drugs, which can overcome some of the problems of conventional pharmacology. © 2019 Elsevier B.V.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/201805
url http://hdl.handle.net/10261/201805
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.mce.2019.03.003
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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