Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction
BACKGROUND: Lung ultrasound (LUS) has emerged as a useful tool in the acute phase of patients admitted for ST-segment- elevation myocardial infarction. However, its long-term significance remains uncertain, and risk scores do not include LUS findings as a predictor. This study aims to assess the 1-y...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:324383 |
| Acesso em linha: | https://ddd.uab.cat/record/324383 https://dx.doi.org/urn:doi:10.1161/JAHA.124.035688 |
| Access Level: | acceso abierto |
| Palavra-chave: | B-lines GRACE score STEMI lung ultrasound |
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Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction1-Year Prognosis and Improvement in Risk PredictionVidal Burdeus, María|||0000-0002-9823-5021Simón-Ramón, C.|||0000-0003-1136-4005Sionis, Alessandro|||0000-0003-0843-9512Izquierdo Marquisá, Andrea|||0000-0002-3610-7497Farré, Núria|||0000-0003-3110-6572Tizón-Marcos, Helena|||0000-0001-7942-9413Milà Pascual, Laia|||0009-0007-4932-657XCarreras-Mora, José|||0000-0003-2519-5177Rodríguez-González, ClaraRodríguez-Sotelo, Laura|||0000-0001-7825-5714Giralt-Borrell, T.Martínez Membrive, María José|||0000-0002-3400-7003Cainzos-Achirica, Miguel|||0000-0002-3805-9089García Picart, JoanVaquerizo Montilla, Beatriz|||0000-0002-1428-3596Rivas-Lasarte, Mercedes|||0000-0002-8704-3104Ribas Barquet, Núria|||0000-0003-1492-5285B-linesGRACE scoreSTEMIlung ultrasoundBACKGROUND: Lung ultrasound (LUS) has emerged as a useful tool in the acute phase of patients admitted for ST-segment- elevation myocardial infarction. However, its long-term significance remains uncertain, and risk scores do not include LUS findings as a predictor. This study aims to assess the 1-year prognostic value of LUS and its ability to enhance existing risk scores. METHODS AND RESULTS: This is a multicenter prospective cohort study involving 373 patients with ST-segment-elevation myocardial infarction. LUS was performed during the first 24 hours after angiography. LUS results were assessed both as a categorical (wet/dry lung) and continuous variable (LUS score). The primary end point comprised the following major adverse cardiovascular events: all-cause mortality or hospitalization for heart failure, acute coronary syndrome, or stroke within 1 year. We also evaluated whether LUS could enhance the predictive value of the GRACE (Global Registry of Acute Coronary Events) score. Major adverse cardiovascular events occurred in 51 (13.7%) patients over a median follow-up of 368 days. After multi-variate analysis, the LUS score was an independent predictor (hazard ratio [HR], 1.06 [95% CI, 1.01-1.10]; P=0.009] for each additional B-line), whereas the categorical classification was an independent predictor in patients with ST-segment-elevation myocardial infarction Killip I (HR, 3.12 [95% CI, 1.34-7.31]; P=0.009). Incorporating LUS into GRACE resulted in a net reclassification index of 31.6% and a significant increase in the area under the curve; GRACE alone scored 0.705 compared with GRACE+LUS 0.791 (P=0.002). CONCLUSIONS: Detecting B-lines on LUS at the acute phase predicts major adverse cardiovascular events at 1 year in patients with ST-segment-elevation myocardial infarction and enhances the predictive value of the GRACE score. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04526535.Universitat Autònoma de Barcelona. Departament de Medicina 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/324383https://dx.doi.org/urn:doi:10.1161/JAHA.124.035688reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3243832026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction 1-Year Prognosis and Improvement in Risk Prediction |
| title |
Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction |
| spellingShingle |
Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction Vidal Burdeus, María|||0000-0002-9823-5021 B-lines GRACE score STEMI lung ultrasound |
| title_short |
Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction |
| title_full |
Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction |
| title_fullStr |
Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction |
| title_full_unstemmed |
Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction |
| title_sort |
Lung Ultrasound in the Acute Phase of ST-Segment-Elevation Acute Myocardial Infarction |
| dc.creator.none.fl_str_mv |
Vidal Burdeus, María|||0000-0002-9823-5021 Simón-Ramón, C.|||0000-0003-1136-4005 Sionis, Alessandro|||0000-0003-0843-9512 Izquierdo Marquisá, Andrea|||0000-0002-3610-7497 Farré, Núria|||0000-0003-3110-6572 Tizón-Marcos, Helena|||0000-0001-7942-9413 Milà Pascual, Laia|||0009-0007-4932-657X Carreras-Mora, José|||0000-0003-2519-5177 Rodríguez-González, Clara Rodríguez-Sotelo, Laura|||0000-0001-7825-5714 Giralt-Borrell, T. Martínez Membrive, María José|||0000-0002-3400-7003 Cainzos-Achirica, Miguel|||0000-0002-3805-9089 García Picart, Joan Vaquerizo Montilla, Beatriz|||0000-0002-1428-3596 Rivas-Lasarte, Mercedes|||0000-0002-8704-3104 Ribas Barquet, Núria|||0000-0003-1492-5285 |
| author |
Vidal Burdeus, María|||0000-0002-9823-5021 |
| author_facet |
Vidal Burdeus, María|||0000-0002-9823-5021 Simón-Ramón, C.|||0000-0003-1136-4005 Sionis, Alessandro|||0000-0003-0843-9512 Izquierdo Marquisá, Andrea|||0000-0002-3610-7497 Farré, Núria|||0000-0003-3110-6572 Tizón-Marcos, Helena|||0000-0001-7942-9413 Milà Pascual, Laia|||0009-0007-4932-657X Carreras-Mora, José|||0000-0003-2519-5177 Rodríguez-González, Clara Rodríguez-Sotelo, Laura|||0000-0001-7825-5714 Giralt-Borrell, T. Martínez Membrive, María José|||0000-0002-3400-7003 Cainzos-Achirica, Miguel|||0000-0002-3805-9089 García Picart, Joan Vaquerizo Montilla, Beatriz|||0000-0002-1428-3596 Rivas-Lasarte, Mercedes|||0000-0002-8704-3104 Ribas Barquet, Núria|||0000-0003-1492-5285 |
| author_role |
author |
| author2 |
Simón-Ramón, C.|||0000-0003-1136-4005 Sionis, Alessandro|||0000-0003-0843-9512 Izquierdo Marquisá, Andrea|||0000-0002-3610-7497 Farré, Núria|||0000-0003-3110-6572 Tizón-Marcos, Helena|||0000-0001-7942-9413 Milà Pascual, Laia|||0009-0007-4932-657X Carreras-Mora, José|||0000-0003-2519-5177 Rodríguez-González, Clara Rodríguez-Sotelo, Laura|||0000-0001-7825-5714 Giralt-Borrell, T. Martínez Membrive, María José|||0000-0002-3400-7003 Cainzos-Achirica, Miguel|||0000-0002-3805-9089 García Picart, Joan Vaquerizo Montilla, Beatriz|||0000-0002-1428-3596 Rivas-Lasarte, Mercedes|||0000-0002-8704-3104 Ribas Barquet, Núria|||0000-0003-1492-5285 |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Medicina |
| dc.subject.none.fl_str_mv |
B-lines GRACE score STEMI lung ultrasound |
| topic |
B-lines GRACE score STEMI lung ultrasound |
| description |
BACKGROUND: Lung ultrasound (LUS) has emerged as a useful tool in the acute phase of patients admitted for ST-segment- elevation myocardial infarction. However, its long-term significance remains uncertain, and risk scores do not include LUS findings as a predictor. This study aims to assess the 1-year prognostic value of LUS and its ability to enhance existing risk scores. METHODS AND RESULTS: This is a multicenter prospective cohort study involving 373 patients with ST-segment-elevation myocardial infarction. LUS was performed during the first 24 hours after angiography. LUS results were assessed both as a categorical (wet/dry lung) and continuous variable (LUS score). The primary end point comprised the following major adverse cardiovascular events: all-cause mortality or hospitalization for heart failure, acute coronary syndrome, or stroke within 1 year. We also evaluated whether LUS could enhance the predictive value of the GRACE (Global Registry of Acute Coronary Events) score. Major adverse cardiovascular events occurred in 51 (13.7%) patients over a median follow-up of 368 days. After multi-variate analysis, the LUS score was an independent predictor (hazard ratio [HR], 1.06 [95% CI, 1.01-1.10]; P=0.009] for each additional B-line), whereas the categorical classification was an independent predictor in patients with ST-segment-elevation myocardial infarction Killip I (HR, 3.12 [95% CI, 1.34-7.31]; P=0.009). Incorporating LUS into GRACE resulted in a net reclassification index of 31.6% and a significant increase in the area under the curve; GRACE alone scored 0.705 compared with GRACE+LUS 0.791 (P=0.002). CONCLUSIONS: Detecting B-lines on LUS at the acute phase predicts major adverse cardiovascular events at 1 year in patients with ST-segment-elevation myocardial infarction and enhances the predictive value of the GRACE score. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04526535. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/324383 https://dx.doi.org/urn:doi:10.1161/JAHA.124.035688 |
| url |
https://ddd.uab.cat/record/324383 https://dx.doi.org/urn:doi:10.1161/JAHA.124.035688 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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