Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD

We thank Gloria González-Aseguinolaza for kindly supplying the EalbAATp promoter. Financial support statement: This study was supported by the Ministry of Spain (MINECO) (SAF2014-52223-C2-1-R to DS, SAF2017-83813-C3-1-R to DS and LH, SAF2017-82813-C3-3R to NC co-financed by the European Regional Dev...

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Detalles Bibliográficos
Autores: Weber, Minéia, Mera, Paula, Casas, Josefina, Salvador, Javier, Rodríguez, Amaia, Alonso, Sergio, Sebastián, David, Soler-Vázquez, M. Carmen, Montironi, Carla, Recalde, Sandra, Fucho, Raquel, Calderón-Domínguez, María, Mir, Joan Francesc, Bartrons, Ramon, Escola-Gil, Joan Carles, Sánchez-Infantes, David, Zorzano, Antonio, Llorente-Cortes, Vicenta, Casals i Farré, Núria, Valentí, Víctor, Frühbeck, Gema, Herrero Rodríguez, Laura, Serra, Dolors
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/1703
Acceso en línea:http://hdl.handle.net/20.500.12328/1703
https://dx.doi.org/10.1096/fj.202000678R
Access Level:acceso abierto
Palabra clave:Oxidació
Àcids grassos
Teràpia genètica
Esteatosi hepàtica
Marcadors bioquímics
Obesitat
Fetge
Oxidación
Ácidos grasos
Terapia genética
Esteatosis hepática
Marcadores bioquímicos
Obesidad
Hígado
Oxidation
Fatty acids
Genetic therapy
Hepatic steatosis
Biochemical markers
Obesity
Liver
61
616.4
Descripción
Sumario:We thank Gloria González-Aseguinolaza for kindly supplying the EalbAATp promoter. Financial support statement: This study was supported by the Ministry of Spain (MINECO) (SAF2014-52223-C2-1-R to DS, SAF2017-83813-C3-1-R to DS and LH, SAF2017-82813-C3-3R to NC co-financed by the European Regional Development Fund [ERDF], a doctoral fellowship to JFM, and a Juan de la Cierva—Incorporación research fellowship [IJCI-2016-28313] to PM and DS), the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN) (CB06/03/0001 to DS), the Government of Catalonia (2014SGR465 to DS), Instituto de Salud Carlos III (FISPI18/01584 to VL-C, FIS-PI17/00412 to RB, FIS PI18/01484 to SA and FIS17/01455 to DS-I, Miguel Servet Fund CP15/00106 to DS-I and Rio Hortega grant (CM19/00039) to CM) and co-financed by the European Regional Development Fund (ERDF), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) to JC-EG, the Fundació La Marató de TV3 (201627-30 to DS and 201627-31 to NC), the European Foundation for the Study of Diabetes (EFSD)/Lilly and EFSD/Janssen-Rising Star and L'Oréal-UNESCO “For Women in Science” research fellowships to LH, a doctoral fellowship from the Ciência sem Fronteiras-CNPq (237976/2012-9) to MW. Figure 4F was created with BioRender.com.

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