Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications
Cellular senescence; Prostate cancer; Senescence-associated secretory phenotype
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/14103 |
| Acceso en línea: | http://hdl.handle.net/11351/14103 |
| Access Level: | acceso abierto |
| Palabra clave: | Medicaments antineoplàstics - Ús terapèutic Pròstata - Càncer - Tractament DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence Other subheadings::Other subheadings::/drug effects CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::/therapeutic use ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular Otros calificadores::Otros calificadores::/efectos de los fármacos COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::/uso terapéutico |
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| dc.title.none.fl_str_mv |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications |
| title |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications |
| spellingShingle |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications Bacca, Luisa Medicaments antineoplàstics - Ús terapèutic Pròstata - Càncer - Tractament DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence Other subheadings::Other subheadings::/drug effects CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::/therapeutic use ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular Otros calificadores::Otros calificadores::/efectos de los fármacos COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::/uso terapéutico |
| title_short |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications |
| title_full |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications |
| title_fullStr |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications |
| title_full_unstemmed |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications |
| title_sort |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications |
| dc.creator.none.fl_str_mv |
Bacca, Luisa Zivi, Andrea Labbé, David Brandariz, Julian Zacchi, Francesca Mateo, Joaquin |
| author |
Bacca, Luisa |
| author_facet |
Bacca, Luisa Zivi, Andrea Labbé, David Brandariz, Julian Zacchi, Francesca Mateo, Joaquin |
| author_role |
author |
| author2 |
Zivi, Andrea Labbé, David Brandariz, Julian Zacchi, Francesca Mateo, Joaquin |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Bacca L] Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada. Division of Clinical and Translational Research, Department of Medicine, McGill University, Montréal, Québec, Canada. [Brandariz J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Zacchi F, Zivi A] Section of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy. [Mateo J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Labbé DP] Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada. Division of Clinical and Translational Research, Department of Medicine, McGill University, Montréal, Québec, Canada. Division of Urology, Department of Surgery, McGill University, Montréal, Québec, Canada Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Medicaments antineoplàstics - Ús terapèutic Pròstata - Càncer - Tractament DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence Other subheadings::Other subheadings::/drug effects CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::/therapeutic use ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular Otros calificadores::Otros calificadores::/efectos de los fármacos COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::/uso terapéutico |
| topic |
Medicaments antineoplàstics - Ús terapèutic Pròstata - Càncer - Tractament DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence Other subheadings::Other subheadings::/drug effects CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::/therapeutic use ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular Otros calificadores::Otros calificadores::/efectos de los fármacos COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::/uso terapéutico |
| description |
Cellular senescence; Prostate cancer; Senescence-associated secretory phenotype |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11351/14103 http://hdl.handle.net/11351/14103 |
| url |
http://hdl.handle.net/11351/14103 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Gene;972 https://doi.org/10.1016/j.gene.2025.149774 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
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| _version_ |
1869420742152552448 |
| spelling |
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implicationsBacca, LuisaZivi, AndreaLabbé, DavidBrandariz, JulianZacchi, FrancescaMateo, JoaquinMedicaments antineoplàstics - Ús terapèuticPròstata - Càncer - TractamentDISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic NeoplasmsOther subheadings::Other subheadings::Other subheadings::/drug therapyPHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular SenescenceOther subheadings::Other subheadings::/drug effectsCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic AgentsOther subheadings::Other subheadings::/therapeutic useENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstataOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaFENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celularOtros calificadores::Otros calificadores::/efectos de los fármacosCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicosOtros calificadores::Otros calificadores::/uso terapéuticoCellular senescence; Prostate cancer; Senescence-associated secretory phenotypeSenescència cel·lular; Càncer de pròstata; Fenotip secretor associat a la senescènciaSenescencia celular; Cáncer de próstata; Fenotipo secretor asociado a la senescenciaProstate cancer (PCa) remains a major cause of cancer-related mortality in men, particularly in its advanced and metastatic stages. While various systemic therapies have improved clinical outcomes, therapy resistance and disease progression remain significant challenges. One critical, yet underappreciated, mechanism influencing treatment response is therapy-induced senescence (TIS), a stable form of cell cycle arrest triggered by anticancer treatments. In PCa, TIS can be elicited by chemotherapy, radiotherapy, hormonal therapies, and targeted agents, and is characterized by a complex interplay of tumor-suppressive and tumor-promoting effects, largely mediated through the senescence-associated secretory phenotype (SASP). This review explores the molecular mechanisms of senescence, the diverse therapeutic strategies that induce it, and the dual roles it plays in PCa progression and treatment resistance. We further discuss emerging approaches that combine senescence-inducing therapies with senescence-targeting strategies, such as senolytics and senomorphics, to mitigate the adverse consequences of persistent senescent PCa cells. Finally, we highlight ongoing clinical trials, translational barriers, and future directions in integrating senotherapy into the clinical management of PCa.ElsevierInstitut Català de la Salut[Bacca L] Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada. Division of Clinical and Translational Research, Department of Medicine, McGill University, Montréal, Québec, Canada. [Brandariz J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Zacchi F, Zivi A] Section of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy. [Mateo J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Labbé DP] Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada. Division of Clinical and Translational Research, Department of Medicine, McGill University, Montréal, Québec, Canada. Division of Urology, Department of Surgery, McGill University, Montréal, Québec, CanadaVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/14103http://hdl.handle.net/11351/14103Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésGene;972https://doi.org/10.1016/j.gene.2025.149774Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/141032026-05-29T05:05:01Z |
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15,812429 |