Specific tyrosine phosphorylation in response to bile in Fasciola hepatica and Echinostoma friedi
Protein tyrosine phosphorylation (PY) is a well-known signalling mechanism which is also involved in host–parasite interactions. Despite its transcendence, PY has been poorly studied in parasitic helminths. The aim of this study is to examine the effect of bile salts on the PY pattern in parasitic t...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2004 |
| País: | España |
| Institución: | Universidad Católica de Valencia San Vicente Mártir |
| Repositorio: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| Idioma: | inglés |
| OAI Identifier: | oai:riucv.ucv.es:20.500.12466/4480 |
| Acceso en línea: | http://hdl.handle.net/20.500.12466/4480 |
| Access Level: | acceso abierto |
| Palabra clave: | Tyrosine phosphorylation Fasciola hepatica Echinostoma friedi Protein extracts Western-immunoblotting 32 Ciencias Médicas |
| Sumario: | Protein tyrosine phosphorylation (PY) is a well-known signalling mechanism which is also involved in host–parasite interactions. Despite its transcendence, PY has been poorly studied in parasitic helminths. The aim of this study is to examine the effect of bile salts on the PY pattern in parasitic trematodes. Two distinct adult models were analysed: Echinostoma friedi, of intestinal habitat, and Fasciola hepatica, naturally inhabitant of host biliary channels. Our results show that bile salts induce specific and distinct protein PY in both trematode species, indicating that this signalling process seems to be also involved in host–trematode relationships. |
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