Forensic Ancestry Analysis with Autosomal Polymorphisms

The inference of ancestry from biological material left at a crimescene has been a longstanding but specialised forensic technique, often lacking sufficient detail to make a reliable inference of ancestr y. This thesis describes the key steps in developing a forensic ancestry test that can be adopte...

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Detalles Bibliográficos
Autor: Phillips, Christopher Paul
Tipo de recurso: tesis doctoral
Fecha de publicación:2017
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/16134
Acceso en línea:http://hdl.handle.net/10347/16134
Access Level:acceso abierto
Palabra clave:Materias::Investigación::24 Ciencias de la vida::2409 Genética::240903 Genética de poblaciones
Descripción
Sumario:The inference of ancestry from biological material left at a crimescene has been a longstanding but specialised forensic technique, often lacking sufficient detail to make a reliable inference of ancestr y. This thesis describes the key steps in developing a forensic ancestry test that can be adopted by any laboratory using capillary electrophoresis equipment: optimisation of a PCR multiplex to detect DNA markers from contact traces; compilation of population data from which to infer the likely pop ulation of origin of the person; detection of coancestry patterns in an individual with admixed backgr ounds; and development of online statistical tools that calculate the probability of an individual’s an cestry from a submitted SNP profile. Additional types of autosomal markers were compiled from Ind el polymorphisms; short tandem repeats (STRs); multiple allele SNPs; and Microhaplotype markers.

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