Intercalative DNA binding of the marine anticancer drug variolin B

Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DN...

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Detalles Bibliográficos
Autores: Canals, Albert, Arribas Bosacoma, Raquel, Albericio Palomera, Fernando, Álvarez Domingo, Mercedes, Aymamí, Joan, Coll, Miquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/131078
Acceso en línea:https://hdl.handle.net/2445/131078
Access Level:acceso abierto
Palabra clave:Alcaloides
Medicaments antineoplàstics
ADN
Medicaments antivírics
Alkaloids
Antineoplastic agents
DNA
Antiviral agents
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spelling Intercalative DNA binding of the marine anticancer drug variolin BCanals, AlbertArribas Bosacoma, RaquelAlbericio Palomera, FernandoÁlvarez Domingo, MercedesAymamí, JoanColl, MiquelAlcaloidesMedicaments antineoplàsticsADNMedicaments antivíricsAlkaloidsAntineoplastic agentsDNAAntiviral agentsVariolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.Nature Publishing Group2019201920172019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 p.application/pdfhttps://hdl.handle.net/2445/131078Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/srep39680Scientific Reports, 2017, vol. 7, num. 39680https://doi.org/10.1038/srep39680cc-by (c) Canals, Albert et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1310782026-05-29T05:05:01Z
dc.title.none.fl_str_mv Intercalative DNA binding of the marine anticancer drug variolin B
title Intercalative DNA binding of the marine anticancer drug variolin B
spellingShingle Intercalative DNA binding of the marine anticancer drug variolin B
Canals, Albert
Alcaloides
Medicaments antineoplàstics
ADN
Medicaments antivírics
Alkaloids
Antineoplastic agents
DNA
Antiviral agents
title_short Intercalative DNA binding of the marine anticancer drug variolin B
title_full Intercalative DNA binding of the marine anticancer drug variolin B
title_fullStr Intercalative DNA binding of the marine anticancer drug variolin B
title_full_unstemmed Intercalative DNA binding of the marine anticancer drug variolin B
title_sort Intercalative DNA binding of the marine anticancer drug variolin B
dc.creator.none.fl_str_mv Canals, Albert
Arribas Bosacoma, Raquel
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Aymamí, Joan
Coll, Miquel
author Canals, Albert
author_facet Canals, Albert
Arribas Bosacoma, Raquel
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Aymamí, Joan
Coll, Miquel
author_role author
author2 Arribas Bosacoma, Raquel
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Aymamí, Joan
Coll, Miquel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Alcaloides
Medicaments antineoplàstics
ADN
Medicaments antivírics
Alkaloids
Antineoplastic agents
DNA
Antiviral agents
topic Alcaloides
Medicaments antineoplàstics
ADN
Medicaments antivírics
Alkaloids
Antineoplastic agents
DNA
Antiviral agents
description Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/131078
url https://hdl.handle.net/2445/131078
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/srep39680
Scientific Reports, 2017, vol. 7, num. 39680
https://doi.org/10.1038/srep39680
dc.rights.none.fl_str_mv cc-by (c) Canals, Albert et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Canals, Albert et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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