Effect of donor human milk on host-gut microbiota and metabolic interactions in preterm infants
Background & aims: Human milk is the gold standard for infant nutrition. Preterm infants whose mothers are unable to provide sufficient own mother's milk (OMM), receive pasteurized donor human milk (DHM). We studied metabolic signatures of OMM and DHM and their effect on the interplay of th...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/218765 |
| Acceso en línea: | http://hdl.handle.net/10261/218765 |
| Access Level: | acceso abierto |
| Palabra clave: | Donor human milk (DHM) Gut-microbiota Own mother's milk (OMM) Preterm infant Untargeted metabolomics Nutrition http://metadata.un.org/sdg/2 End hunger, achieve food security and improved nutrition and promote sustainable agriculture |
| Sumario: | Background & aims: Human milk is the gold standard for infant nutrition. Preterm infants whose mothers are unable to provide sufficient own mother's milk (OMM), receive pasteurized donor human milk (DHM). We studied metabolic signatures of OMM and DHM and their effect on the interplay of the developing microbiota and infant's metabolism. Methods: Metabolic fingerprinting of OMM and DHM as well as infant's urine was performed using liquid chromatography–mass spectrometry and the infant's stool microbiota was analyzed by 16S rRNA sequencing. Results: Significant differences in the galactose and starch and sucrose metabolism pathways when comparing OMM and DHM, and alterations of the steroid hormone synthesis and pyrimidine metabolism pathways in urine were observed depending on the type of feeding. Differences in the gut-microbiota composition were also identified. Conclusion: The composition of DHM differs from OMM and feeding of DHM has a significant impact on the metabolic phenotype and microbiota of preterm infants. Our data help to understand the origin of the observed changes generating new hypothesis: i) steroid hormones present in HM have a significant influence in the activity of the steroid hormone biosynthesis pathway in preterm infants; ii) the pyrimidine metabolism is modulated in preterm infants by the activity of gut-microbiota. Short- and long-term implications of the observed changes for preterm infants need to be assessed in further studies. |
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