Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts

Beyond inducing epithelial-to-mesenchymal transcription (EMT), transcriptional factors of the Snail, ZEB and Twist families (EMT-TFs) control global plasticity programmes affecting cell stemness and fate. Literature addressing the reactivation of these factors in adult tumour cells is very extensive...

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Detalles Bibliográficos
Autor: Baulida i Estadella, Josep, 1965-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/34988
Acceso en línea:http://hdl.handle.net/10230/34988
http://dx.doi.org/10.1002/1878-0261.12080
Access Level:acceso abierto
Palabra clave:Cèl·lules epitelials
Càncer
Fibroblasts
ZEB
Snail
Twist
Epithelial-to-mesenchymal transition transcription factors
Cancer-associated fibroblasts
Tumour-stroma crosstalk
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repository_id_str
spelling Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblastsBaulida i Estadella, Josep, 1965-Cèl·lules epitelialsCàncerFibroblastsZEBSnailTwistEpithelial-to-mesenchymal transition transcription factorsCancer-associated fibroblastsTumour-stroma crosstalkBeyond inducing epithelial-to-mesenchymal transcription (EMT), transcriptional factors of the Snail, ZEB and Twist families (EMT-TFs) control global plasticity programmes affecting cell stemness and fate. Literature addressing the reactivation of these factors in adult tumour cells is very extensive, as they enable cancer cell plasticity and fuel both tumour initiation and metastatic spread. Incipient data reveal that EMT-TFs are also expressed in fibroblasts, providing these with additional properties. Here, I will review recent reports on the expression of EMT-TFs in cancer-associated fibroblasts (CAFs). The new model suggests that EMT-TFs can be envisioned as essential metastasis and chemoresistance-promoting molecules, thereby enabling coordinated plasticity programmes in parenchyma and stroma-tumour compartments.Wiley201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34988http://dx.doi.org/10.1002/1878-0261.12080reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésMolecular Oncology. 2017 Jul;11(7):847-59Copyright © 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/349882026-06-12T07:21:37Z
dc.title.none.fl_str_mv Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
title Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
spellingShingle Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
Baulida i Estadella, Josep, 1965-
Cèl·lules epitelials
Càncer
Fibroblasts
ZEB
Snail
Twist
Epithelial-to-mesenchymal transition transcription factors
Cancer-associated fibroblasts
Tumour-stroma crosstalk
title_short Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
title_full Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
title_fullStr Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
title_full_unstemmed Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
title_sort Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts
dc.creator.none.fl_str_mv Baulida i Estadella, Josep, 1965-
author Baulida i Estadella, Josep, 1965-
author_facet Baulida i Estadella, Josep, 1965-
author_role author
dc.subject.none.fl_str_mv Cèl·lules epitelials
Càncer
Fibroblasts
ZEB
Snail
Twist
Epithelial-to-mesenchymal transition transcription factors
Cancer-associated fibroblasts
Tumour-stroma crosstalk
topic Cèl·lules epitelials
Càncer
Fibroblasts
ZEB
Snail
Twist
Epithelial-to-mesenchymal transition transcription factors
Cancer-associated fibroblasts
Tumour-stroma crosstalk
description Beyond inducing epithelial-to-mesenchymal transcription (EMT), transcriptional factors of the Snail, ZEB and Twist families (EMT-TFs) control global plasticity programmes affecting cell stemness and fate. Literature addressing the reactivation of these factors in adult tumour cells is very extensive, as they enable cancer cell plasticity and fuel both tumour initiation and metastatic spread. Incipient data reveal that EMT-TFs are also expressed in fibroblasts, providing these with additional properties. Here, I will review recent reports on the expression of EMT-TFs in cancer-associated fibroblasts (CAFs). The new model suggests that EMT-TFs can be envisioned as essential metastasis and chemoresistance-promoting molecules, thereby enabling coordinated plasticity programmes in parenchyma and stroma-tumour compartments.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34988
http://dx.doi.org/10.1002/1878-0261.12080
url http://hdl.handle.net/10230/34988
http://dx.doi.org/10.1002/1878-0261.12080
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular Oncology. 2017 Jul;11(7):847-59
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420624917561344
score 15,811543

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