Dermcidin has antiviral activity and protects against influenza

Corell-Escuin, Paula; Belmonte-Ballester, Sonia; Adhav, Anmol; Marina, Alberto; Gadea-Salom, Laura; Martínez-Gil, Luis; Aledavood, Elnaz; Fernández-Escamilla, Ana María; Gómez Sáez, Ana; Gougeard, Nadine; Dee, Kieran; Murcia, Pablo R.; Magos, Eliza Adriana; Llena, Carmen; Peris-Martínez, Cristina; D'Auria, Giuseppe; Artacho, Alejandro; Mengual-Chulia, Beatriz; López-Labrador, F. Xavier; Mira, Alex; Ferrer, Maria Desamparados

Dermcidin has antiviral activity and protects against influenza

10 páginas, 5 figuras

Detalles Bibliográficos
Autores:	Corell-Escuin, Paula, Belmonte-Ballester, Sonia, Adhav, Anmol, Marina, Alberto, Gadea-Salom, Laura, Martínez-Gil, Luis, Aledavood, Elnaz, Fernández-Escamilla, Ana María, Gómez Sáez, Ana, Gougeard, Nadine, Dee, Kieran, Murcia, Pablo R., Magos, Eliza Adriana, Llena, Carmen, Peris-Martínez, Cristina, D'Auria, Giuseppe, Artacho, Alejandro, Mengual-Chulia, Beatriz, López-Labrador, F. Xavier, Mira, Alex, Ferrer, Maria Desamparados
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2026
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:dnet:digitalcsic_::9cc83a264174e6e43e44b9e037d93f52
Acceso en línea:	http://hdl.handle.net/10261/427302
Access Level:	acceso abierto
Palabra clave:	Antiviral activity Dermcidin Hemagglutinin Influenza virus Respiratory viruses

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spelling	Dermcidin has antiviral activity and protects against influenzaCorell-Escuin, PaulaBelmonte-Ballester, SoniaAdhav, AnmolMarina, AlbertoGadea-Salom, LauraMartínez-Gil, LuisAledavood, ElnazFernández-Escamilla, Ana MaríaGómez Sáez, AnaGougeard, NadineDee, KieranMurcia, Pablo R.Magos, Eliza AdrianaLlena, CarmenPeris-Martínez, CristinaD'Auria, GiuseppeArtacho, AlejandroMengual-Chulia, BeatrizLópez-Labrador, F. XavierMira, AlexFerrer, Maria DesamparadosAntiviral activityDermcidinHemagglutininInfluenza virusRespiratory viruses10 páginas, 5 figurasDespite the high incidence of influenza virus infections, one-fifth of people infected with influenza remain asymptomatic. The mechanisms associated with this immune resilience are, however, unknown. Here, we show that the human antimicrobial peptide dermcidin has antiviral activity against influenza viruses through binding to hemagglutinin and extends its effect to taxonomically unrelated respiratory viruses such as measles virus and human coronavirus OC43. We show that dermcidin is present in all anatomical regions associated with the entry routes of respiratory viruses, that its levels increase during viral respiratory infections, and that it protects mice against influenza disease. Notably, dermcidin levels were higher in asymptomatic individuals than in susceptible peers, suggesting a role in the onset of disease symptoms. Thus, we show that dermcidin inhibits influenza virus infection in vitro and in vivo, with potential as a human-derived product for the prevention and treatment of respiratory viral infections.This study was supported by grants INNVAL20/19/006 and INNVA2/2021/3 from the Valencian Innovation Agency (AVI), FISABIO Innovation grant PAPIRO UGP-21-047, an EXPLORA Action from the Spanish Ministry of Science and Innovation with code SAF2013-505553-EXP, CIPROM/2023/30 from Regional Ministry of Education, Culture, Universities, and Employment of the Valencian Government, PID2022-137201NB-I00 from the Spanish Ministry of Science and Innovation and by the Carlos III Health Institute, under file code CP22/00036, pursuant to the Resolution of the Director of the Carlos III Health Institute, O.A., M.P., dated December 7, 2022, granting the Miguel Servet Contracts, and cofinanced by the European Union. We thank the patients and the IBSP-CV Biobank (PT17/0015/0017) integrated in the Spanish National Biobanks Network and in the Valencian Biobanking Network for collaboration. We also thank the Central Service for Experimental Research of Universitat de València for the sequencing. Finally, we express our gratitude to Dr. Elena Tapia, Eduardo Romanos, Dr. Julián Pardo, and Dr. Maykel Arias from Instituto Aragonés de Ciencias de la Salud for assistance with the animal experiments, to Dr. Florian Krammer for kindly providing baculoviruses expressing PR8 HA ectodomain, Dr. Jeronimo Bravo for sharing insect High Five cells and to Kenneth McCreath for helpful comments on the manuscript. E.A. and A.M.F.-E. thank Dr. Carmen Gil and Dr. Ana Martínez for valuable advice and for providing access to computational resources. Some of the figure graphics were created by using BioRender.com.Peer reviewedNational Academy of Sciences (U.S.)Agència Valenciana de la InnovacióMinisterio de Ciencia e Innovación (España)Generalitat ValencianaInstituto de Salud Carlos IIIEuropean CommissionMarina, Alberto [0000-0002-1334-5273]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/427302reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-137201NB-I00https://doi.org/10.1073/pnas.2424461123Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::9cc83a264174e6e43e44b9e037d93f522026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Dermcidin has antiviral activity and protects against influenza
title	Dermcidin has antiviral activity and protects against influenza
spellingShingle	Dermcidin has antiviral activity and protects against influenza Corell-Escuin, Paula Antiviral activity Dermcidin Hemagglutinin Influenza virus Respiratory viruses
title_short	Dermcidin has antiviral activity and protects against influenza
title_full	Dermcidin has antiviral activity and protects against influenza
title_fullStr	Dermcidin has antiviral activity and protects against influenza
title_full_unstemmed	Dermcidin has antiviral activity and protects against influenza
title_sort	Dermcidin has antiviral activity and protects against influenza
dc.creator.none.fl_str_mv	Corell-Escuin, Paula Belmonte-Ballester, Sonia Adhav, Anmol Marina, Alberto Gadea-Salom, Laura Martínez-Gil, Luis Aledavood, Elnaz Fernández-Escamilla, Ana María Gómez Sáez, Ana Gougeard, Nadine Dee, Kieran Murcia, Pablo R. Magos, Eliza Adriana Llena, Carmen Peris-Martínez, Cristina D'Auria, Giuseppe Artacho, Alejandro Mengual-Chulia, Beatriz López-Labrador, F. Xavier Mira, Alex Ferrer, Maria Desamparados
author	Corell-Escuin, Paula
author_facet	Corell-Escuin, Paula Belmonte-Ballester, Sonia Adhav, Anmol Marina, Alberto Gadea-Salom, Laura Martínez-Gil, Luis Aledavood, Elnaz Fernández-Escamilla, Ana María Gómez Sáez, Ana Gougeard, Nadine Dee, Kieran Murcia, Pablo R. Magos, Eliza Adriana Llena, Carmen Peris-Martínez, Cristina D'Auria, Giuseppe Artacho, Alejandro Mengual-Chulia, Beatriz López-Labrador, F. Xavier Mira, Alex Ferrer, Maria Desamparados
author_role	author
author2	Belmonte-Ballester, Sonia Adhav, Anmol Marina, Alberto Gadea-Salom, Laura Martínez-Gil, Luis Aledavood, Elnaz Fernández-Escamilla, Ana María Gómez Sáez, Ana Gougeard, Nadine Dee, Kieran Murcia, Pablo R. Magos, Eliza Adriana Llena, Carmen Peris-Martínez, Cristina D'Auria, Giuseppe Artacho, Alejandro Mengual-Chulia, Beatriz López-Labrador, F. Xavier Mira, Alex Ferrer, Maria Desamparados
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Agència Valenciana de la Innovació Ministerio de Ciencia e Innovación (España) Generalitat Valenciana Instituto de Salud Carlos III European Commission Marina, Alberto [0000-0002-1334-5273] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Antiviral activity Dermcidin Hemagglutinin Influenza virus Respiratory viruses
topic	Antiviral activity Dermcidin Hemagglutinin Influenza virus Respiratory viruses
description	10 páginas, 5 figuras
publishDate	2026
dc.date.none.fl_str_mv	2026 2026 2026
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/427302
url	http://hdl.handle.net/10261/427302
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-137201NB-I00 https://doi.org/10.1073/pnas.2424461123 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	National Academy of Sciences (U.S.)
publisher.none.fl_str_mv	National Academy of Sciences (U.S.)
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Dermcidin has antiviral activity and protects against influenza

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