Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

Govarts, Eva; Gilles, Liese; Rodriguez Martin, Laura; Santonen, Tiina; Apel, Petra; Alvito, Paula; Anastasi, Elena; Andersen, Helle Raun; Andersson, Anna-Maria; Andryskova, Lenka; Antignac, Jean-Philippe; Appenzeller, Brice; Barbone, Fabio; Barnett-Itzhaki, Zohar; Barouki, Robert; Berman, Tamar; Bil, Wieneke; Borges, Teresa; Buekers, Jurgen; Cañas Portilla, Ana Isabel; Covaci, Adrian; Csákó, Zsófia; Den Hond, Elly; Dvorakova, Darina; Fábelová, Lucia; Fletcher, Tony; Frederiksen, Hanne; Gabriel, Catherine; Ganzleben, Catherine; Göen, Thomas; Halldórsson, Thórhallur Ingi; Haug, Line S; Horvat, Milena; Huuskonen, Pasi; Imboden, Medea; Jagodic Hudobivnik, Marta; Janasik, Beata; Janev Holcer, Natasa; Karakitsios, Spyros; Katsonouri, Andromachi; Klánová, Jana; Kokaraki, Venetia; Kold Jensen, Tina; Koponen, Jani; Laeremans, Michelle; Laguzzi, Federica; Lange, Rosa; Lemke, Nora; Lignell, Sanna; Lindroos, Anna Karin; Lobo Vicente, Joana; Luijten, Mirjam; Makris, Konstantinos C; Mazej, Darja; Melymuk, Lisa; Meslin, Matthieu; Mol, Hans; Montazeri, Parisa; Murawski, Aline; Namorado, Sónia; Niemann, Lars; Nübler, Stefanie; Nunes, Baltazar; Ólafsdóttir, Kristin; Palkovicova Murinova, Lubica; Papaioannou, Nafsika; Pedraza-Diaz, Susana; Piler, Pavel; Plichta, Veronika; Poteser, Michael; Probst-Hensch, Nicole; Rambaud, Loïc; Rauscher-Gabernig, Elke; Rausova, Katarina; Remy, Sylvie; Riou, Margaux; Rosolen, Valentina; Rousselle, Christophe; Rüther, Maria; Sarigiannis, Denis; Silva, Maria J; Šlejkovec, Zdenka; Snoj Tratnik, Janja; Stajnko, Anja; Szigeti, Tamás; Tarazona, Jose; Thomsen, Cathrine; Tkalec, Žiga; Tolonen, Hanna; Trnovec, Tomas; Uhl, Maria; Van Nieuwenhuyse, An; Vasco, Elsa; Verheyen, Veerle J; Viegas, Susana; Vinggaard, Anne Marie; Vogel, Nina; Vorkamp, Katrin; Wasowicz, Wojciech; Weber, Till; Wimmerova, Sona; Woutersen, Marjolijn; Zimmermann, Philipp; Zvonař, Martin; Koch, Holger M; Kolossa-Gehring, Marike; Esteban-Lopez, Marta; Castaño, Argelia; Stewart, Lorraine; Sepai, Ovnair; Schoeters, Greet

Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referre...

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Autores:	Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, Antignac, Jean-Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas Portilla, Ana Isabel, Covaci, Adrian, Csákó, Zsófia, Den Hond, Elly, Dvorakova, Darina, Fábelová, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldórsson, Thórhallur Ingi, Haug, Line S, Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klánová, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C, Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Ólafsdóttir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J, Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamás, Tarazona, Jose, Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J, Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonař, Martin, Koch, Holger M, Kolossa-Gehring, Marike, Esteban-Lopez, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/16310
Acceso en línea:	http://hdl.handle.net/20.500.12105/16310
Access Level:	acceso abierto
Palabra clave:	Environmental Pollutants Arsenic Pesticides Fluorocarbons Young Adult Humans Child Adolescent Biological Monitoring Cadmium Biomarkers Acrylamides

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oai_identifier_str	oai:repisalud.isciii.es:20.500.12105/16310
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
spellingShingle	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021) Govarts, Eva Environmental Pollutants Arsenic Pesticides Fluorocarbons Young Adult Humans Child Adolescent Biological Monitoring Cadmium Biomarkers Acrylamides
title_short	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title_full	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title_fullStr	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title_full_unstemmed	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title_sort	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
dc.creator.none.fl_str_mv	Govarts, Eva Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna-Maria Andryskova, Lenka Antignac, Jean-Philippe Appenzeller, Brice Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas Portilla, Ana Isabel Covaci, Adrian Csákó, Zsófia Den Hond, Elly Dvorakova, Darina Fábelová, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldórsson, Thórhallur Ingi Haug, Line S Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klánová, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Ólafsdóttir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loïc Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe Rüther, Maria Sarigiannis, Denis Silva, Maria J Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamás Tarazona, Jose Thomsen, Cathrine Tkalec, Žiga Tolonen, Hanna Trnovec, Tomas Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Weber, Till Wimmerova, Sona Woutersen, Marjolijn Zimmermann, Philipp Zvonař, Martin Koch, Holger M Kolossa-Gehring, Marike Esteban-Lopez, Marta Castaño, Argelia Stewart, Lorraine Sepai, Ovnair Schoeters, Greet
author	Govarts, Eva
author_facet	Govarts, Eva Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna-Maria Andryskova, Lenka Antignac, Jean-Philippe Appenzeller, Brice Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas Portilla, Ana Isabel Covaci, Adrian Csákó, Zsófia Den Hond, Elly Dvorakova, Darina Fábelová, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldórsson, Thórhallur Ingi Haug, Line S Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klánová, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Ólafsdóttir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loïc Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe Rüther, Maria Sarigiannis, Denis Silva, Maria J Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamás Tarazona, Jose Thomsen, Cathrine Tkalec, Žiga Tolonen, Hanna Trnovec, Tomas Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Weber, Till Wimmerova, Sona Woutersen, Marjolijn Zimmermann, Philipp Zvonař, Martin Koch, Holger M Kolossa-Gehring, Marike Esteban-Lopez, Marta Castaño, Argelia Stewart, Lorraine Sepai, Ovnair Schoeters, Greet
author_role	author
author2	Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna-Maria Andryskova, Lenka Antignac, Jean-Philippe Appenzeller, Brice Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas Portilla, Ana Isabel Covaci, Adrian Csákó, Zsófia Den Hond, Elly Dvorakova, Darina Fábelová, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldórsson, Thórhallur Ingi Haug, Line S Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klánová, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Ólafsdóttir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loïc Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe Rüther, Maria Sarigiannis, Denis Silva, Maria J Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamás Tarazona, Jose Thomsen, Cathrine Tkalec, Žiga Tolonen, Hanna Trnovec, Tomas Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Weber, Till Wimmerova, Sona Woutersen, Marjolijn Zimmermann, Philipp Zvonař, Martin Koch, Holger M Kolossa-Gehring, Marike Esteban-Lopez, Marta Castaño, Argelia Stewart, Lorraine Sepai, Ovnair Schoeters, Greet
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Unión Europea. Comisión Europea. H2020
dc.subject.none.fl_str_mv	Environmental Pollutants Arsenic Pesticides Fluorocarbons Young Adult Humans Child Adolescent Biological Monitoring Cadmium Biomarkers Acrylamides
topic	Environmental Pollutants Arsenic Pesticides Fluorocarbons Young Adult Humans Child Adolescent Biological Monitoring Cadmium Biomarkers Acrylamides
description	As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023-07-25 2023 2023-04-01 2023 2023-04-01
dc.type.none.fl_str_mv	review article http://purl.org/coar/resource_type/c_dcae04bc VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/16310
url	http://hdl.handle.net/20.500.12105/16310
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)Govarts, EvaGilles, LieseRodriguez Martin, LauraSantonen, TiinaApel, PetraAlvito, PaulaAnastasi, ElenaAndersen, Helle RaunAndersson, Anna-MariaAndryskova, LenkaAntignac, Jean-PhilippeAppenzeller, BriceBarbone, FabioBarnett-Itzhaki, ZoharBarouki, RobertBerman, TamarBil, WienekeBorges, TeresaBuekers, JurgenCañas Portilla, Ana IsabelCovaci, AdrianCsákó, ZsófiaDen Hond, EllyDvorakova, DarinaFábelová, LuciaFletcher, TonyFrederiksen, HanneGabriel, CatherineGanzleben, CatherineGöen, ThomasHalldórsson, Thórhallur IngiHaug, Line SHorvat, MilenaHuuskonen, PasiImboden, MedeaJagodic Hudobivnik, MartaJanasik, BeataJanev Holcer, NatasaKarakitsios, SpyrosKatsonouri, AndromachiKlánová, JanaKokaraki, VenetiaKold Jensen, TinaKoponen, JaniLaeremans, MichelleLaguzzi, FedericaLange, RosaLemke, NoraLignell, SannaLindroos, Anna KarinLobo Vicente, JoanaLuijten, MirjamMakris, Konstantinos CMazej, DarjaMelymuk, LisaMeslin, MatthieuMol, HansMontazeri, ParisaMurawski, AlineNamorado, SóniaNiemann, LarsNübler, StefanieNunes, BaltazarÓlafsdóttir, KristinPalkovicova Murinova, LubicaPapaioannou, NafsikaPedraza-Diaz, SusanaPiler, PavelPlichta, VeronikaPoteser, MichaelProbst-Hensch, NicoleRambaud, LoïcRauscher-Gabernig, ElkeRausova, KatarinaRemy, SylvieRiou, MargauxRosolen, ValentinaRousselle, ChristopheRüther, MariaSarigiannis, DenisSilva, Maria JŠlejkovec, ZdenkaSnoj Tratnik, JanjaStajnko, AnjaSzigeti, TamásTarazona, JoseThomsen, CathrineTkalec, ŽigaTolonen, HannaTrnovec, TomasUhl, MariaVan Nieuwenhuyse, AnVasco, ElsaVerheyen, Veerle JViegas, SusanaVinggaard, Anne MarieVogel, NinaVorkamp, KatrinWasowicz, WojciechWeber, TillWimmerova, SonaWoutersen, MarjolijnZimmermann, PhilippZvonař, MartinKoch, Holger MKolossa-Gehring, MarikeEsteban-Lopez, MartaCastaño, ArgeliaStewart, LorraineSepai, OvnairSchoeters, GreetEnvironmental PollutantsArsenicPesticidesFluorocarbonsYoung AdultHumansChildAdolescentBiological MonitoringCadmiumBiomarkersAcrylamidesAs one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures.ElsevierUnión Europea. Comisión Europea. H202020232023-07-2520232023-04-0120232023-04-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/16310reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/163102026-06-12T12:43:37Z
score	15,811543

Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

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