The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.

14 páginas, 8 figuras, 1 tabla. Material suplementario accesible online.

Detalles Bibliográficos
Autores: Zhang, Feifan, Bhattacharya, Abhishek, Nelson, Jessica C., Abe, Namiko, Gordon, Patricia, Lloret-Fernández, Carla, Maicas, Miren, Flames, Nuria, Mann, Richard S., Colón-Ramos, Daniel A., Hobert, Oliver
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/149771
Acceso en línea:http://hdl.handle.net/10261/149771
Access Level:acceso abierto
Palabra clave:Caenorhabditis elegans
Homeobox
Neuron differentiation
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spelling The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.Zhang, FeifanBhattacharya, AbhishekNelson, Jessica C.Abe, NamikoGordon, PatriciaLloret-Fernández, CarlaMaicas, MirenFlames, NuriaMann, Richard S.Colón-Ramos, Daniel A.Hobert, OliverCaenorhabditis elegansHomeoboxNeuron differentiation14 páginas, 8 figuras, 1 tabla. Material suplementario accesible online.Transcription factors that drive neuron type-specific terminal differentiation programs in the developing nervous system are often expressed in several distinct neuronal cell types, but to what extent they have similar or distinct activities in individual neuronal cell types is generally not well explored. We investigate this problem using, as a starting point, the C. elegans LIM homeodomain transcription factor ttx-3, which acts as a terminal selector to drive the terminal differentiation program of the cholinergic AIY interneuron class. Using a panel of different terminal differentiation markers, including neurotransmitter synthesizing enzymes, neurotransmitter receptors and neuropeptides, we show that ttx-3 also controls the terminal differentiation program of two additional, distinct neuron types, namely the cholinergic AIA interneurons and the serotonergic NSM neurons. We show that the type of differentiation program that is controlled by ttx-3 in different neuron types is specified by a distinct set of collaborating transcription factors. One of the collaborating transcription factors is the POU homeobox gene unc-86, which collaborates with ttx-3 to determine the identity of the serotonergic NSM neurons. unc-86 in turn operates independently of ttx-3 in the anterior ganglion where it collaborates with the ARID-type transcription factor cfi-1 to determine the cholinergic identity of the IL2 sensory and URA motor neurons. In conclusion, transcription factors operate as terminal selectors in distinct combinations in different neuron types, defining neuron type-specific identity features.This work was funded by the National Institutes of Health [R01NS039996-05 and R01NS050266-03 to O.H.; R01NS076558 to D.A.C.-R.; and R01NS070644 to R.S.M.]; a March of Dimes Foundation Grant (to D.A.C.-R.); the Spanish Government [SAF2011-26273 to N.F.]; a Marie Curie Career Integration Grant (to N.F.); a VAL i+d Fellowship from Generalitat Valenciana (to C.L.-F.); and a European Research Council Starting Grant (to N.F.). N.F. is a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator. O.H. is an Investigator of the Howard Hughes Medical Institute. Deposited in PMC for release after 6 months.Peer reviewedCompany of BiologistsNational Institutes of Health (US)European Research CouncilConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201720172013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/149771reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#MICINN/SAF2011/26273http://dx.doi.org/10.1242/dev.099721Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1497712026-05-22T06:33:51Z
dc.title.none.fl_str_mv The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
title The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
spellingShingle The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
Zhang, Feifan
Caenorhabditis elegans
Homeobox
Neuron differentiation
title_short The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
title_full The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
title_fullStr The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
title_full_unstemmed The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
title_sort The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
dc.creator.none.fl_str_mv Zhang, Feifan
Bhattacharya, Abhishek
Nelson, Jessica C.
Abe, Namiko
Gordon, Patricia
Lloret-Fernández, Carla
Maicas, Miren
Flames, Nuria
Mann, Richard S.
Colón-Ramos, Daniel A.
Hobert, Oliver
author Zhang, Feifan
author_facet Zhang, Feifan
Bhattacharya, Abhishek
Nelson, Jessica C.
Abe, Namiko
Gordon, Patricia
Lloret-Fernández, Carla
Maicas, Miren
Flames, Nuria
Mann, Richard S.
Colón-Ramos, Daniel A.
Hobert, Oliver
author_role author
author2 Bhattacharya, Abhishek
Nelson, Jessica C.
Abe, Namiko
Gordon, Patricia
Lloret-Fernández, Carla
Maicas, Miren
Flames, Nuria
Mann, Richard S.
Colón-Ramos, Daniel A.
Hobert, Oliver
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv National Institutes of Health (US)
European Research Council
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Caenorhabditis elegans
Homeobox
Neuron differentiation
topic Caenorhabditis elegans
Homeobox
Neuron differentiation
description 14 páginas, 8 figuras, 1 tabla. Material suplementario accesible online.
publishDate 2013
dc.date.none.fl_str_mv 2013
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/149771
url http://hdl.handle.net/10261/149771
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
MICINN/SAF2011/26273
http://dx.doi.org/10.1242/dev.099721
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420585197502464
score 15.811543

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