Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder

Producción Científica

Detalles Bibliográficos
Autores: Cea Cañas, Béquer Benjamín, Gómez Pilar, Javier, Núñez Novo, Pablo, Rodríguez Vázquez, Eva, Uribe, Nieves de, Díez Revuelta, Álvaro, Pérez Escudero, Adela, Molina Rodríguez, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/63822
Acceso en línea:https://doi.org/10.1016/j.pnpbp.2019.109801
https://uvadoc.uva.es/handle/10324/63822
Access Level:acceso abierto
Palabra clave:Connectivity strength
Functional network
Graph-theory
Schizophrenia
Bipolar disorder
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spelling Connectivity strength of the EEG functional network in schizophrenia and bipolar disorderCea Cañas, Béquer BenjamínGómez Pilar, JavierNúñez Novo, PabloRodríguez Vázquez, EvaUribe, Nieves deDíez Revuelta, ÁlvaroPérez Escudero, AdelaMolina Rodríguez, VicenteConnectivity strengthFunctional networkGraph-theorySchizophreniaBipolar disorderProducción CientíficaThe application of graph theory measures in the study of functional brain networks allows for the description of their general properties and their alterations in mental illness. Among these measures, connectivity strength (CS) estimates the degree of functional connectivity of the whole network. Previous studies in schizophrenia patients have reported higher baseline CS values and modulation deficits in EEG spectral properties during cognitive activity. The specificity of these alterations and their relationships with pharmacological treatments remain unknown. Therefore, in the present study, we assessed functional CS on EEG-based brain networks in 79 schizophrenia and 29 bipolar patients in addition to 63 healthy controls. The subjects performed a P300 task during the EEG recordings from which the pre-stimulus and the task-related modulation CS values were computed in the global and theta bands. These values were compared between the groups and between the patients who had and had not received different treatments. The global band pre-stimulus CS was significantly higher in the schizophrenia group compared with the bipolar and control groups. Theta band CS modulation was decreased in schizophrenia and bipolar patients. Treatment with antipsychotics, lithium, benzodiazepines, and anticonvulsants did not significantly alter these CS values. The first-episode and chronic schizophrenia patients did not show significant differences in CS values. Higher global band pre-stimulus CS values were associated with worse general cognition in schizophrenia patients. These data support increased connectivity in the whole-brain network that is specific to schizophrenia and suggest a general hyper-synchronized basal state that might hamper cognition in this syndrome.Instituto de Salud Carlos III (PI15/00299; PI18/00178)Gerencia Regional de Salud de Castilla y León (GRS 1485/A/17; GRS 1721/A/18)Consejería de Educación de la Junta de Castilla y León (VA059U13; VA057P17)Ministerio de Educación, Cultura y Deporte (FPU17/00850)Elsevier2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1016/j.pnpbp.2019.109801https://uvadoc.uva.es/handle/10324/63822reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.sciencedirect.com/science/article/pii/S0278584619304725info:eu-repo/semantics/openAccessoai:uvadoc.uva.es:10324/638222026-06-13T12:44:47Z
dc.title.none.fl_str_mv Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder
title Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder
spellingShingle Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder
Cea Cañas, Béquer Benjamín
Connectivity strength
Functional network
Graph-theory
Schizophrenia
Bipolar disorder
title_short Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder
title_full Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder
title_fullStr Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder
title_full_unstemmed Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder
title_sort Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder
dc.creator.none.fl_str_mv Cea Cañas, Béquer Benjamín
Gómez Pilar, Javier
Núñez Novo, Pablo
Rodríguez Vázquez, Eva
Uribe, Nieves de
Díez Revuelta, Álvaro
Pérez Escudero, Adela
Molina Rodríguez, Vicente
author Cea Cañas, Béquer Benjamín
author_facet Cea Cañas, Béquer Benjamín
Gómez Pilar, Javier
Núñez Novo, Pablo
Rodríguez Vázquez, Eva
Uribe, Nieves de
Díez Revuelta, Álvaro
Pérez Escudero, Adela
Molina Rodríguez, Vicente
author_role author
author2 Gómez Pilar, Javier
Núñez Novo, Pablo
Rodríguez Vázquez, Eva
Uribe, Nieves de
Díez Revuelta, Álvaro
Pérez Escudero, Adela
Molina Rodríguez, Vicente
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Connectivity strength
Functional network
Graph-theory
Schizophrenia
Bipolar disorder
topic Connectivity strength
Functional network
Graph-theory
Schizophrenia
Bipolar disorder
description Producción Científica
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.pnpbp.2019.109801
https://uvadoc.uva.es/handle/10324/63822
url https://doi.org/10.1016/j.pnpbp.2019.109801
https://uvadoc.uva.es/handle/10324/63822
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0278584619304725
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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