Clinical features and outcomes of Streptococcus anginosus group infective Endocarditis: a multicenter matched cohort study

[EN] Background. Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. Methods. We performed a retrospective analysis of prospectively collected data from co...

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Detalles Bibliográficos
Autores: Escrihuela-Vidal, Francesc, López Cortés, Luis Eduardo, Escolà Vergé, Laura, De Alarcón, Arístides, Cuervo, Guillermo, Sánchez Porto, Antonio, Fernández-Hidalgo, Núria, Luque, Rafael, Montejo Baranda, José Miguel, Miró, José María, Goenaga, Miguel Ángel, Muñoz, Patricia, Valerio, Maricela C., Ripa, Marco, Sousa Regueiro, Dolores, Gurguí, Mercé, Fariñas, Carmen, Mateu, Lourdes, García Vázquez, Elisa, Gálvez Acebal, Juan, Carratalà, Jordi, Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en España (GAMES), Barcelona Endocarditis Study Team (BEST)
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/52585
Acceso en línea:http://hdl.handle.net/10810/52585
Access Level:acceso abierto
Palabra clave:infective endocarditis
Streptococcus anginosus
viridans group streptococci
Streptococcus gallolyticus
Descripción
Sumario:[EN] Background. Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. Methods. We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis. Results. Of 5336 consecutive cases of definite endocarditis, 72 (1.4%) were due to SAG and matched with 144 cases due to VGS/ SGG. SAG endocarditis was community acquired in 64 (88.9%) cases and affected aortic native valve in 29 (40.3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8.3% vs 3.5%, P = .116); valve disorder, including perforation (22.2% vs 18.1%, P = .584), pseudoaneurysm (16.7% vs 8.3%, P = .108), or prosthesis dehiscence (1.4% vs 6.3%, P = .170); paravalvular complications, including abscess (25% vs 18.8%, P = .264) and intracardiac fistula (5.6% vs 3.5%, P = .485); heart failure (34.7% vs 38.9%, P = .655); or embolic events (41.7% vs 32.6%, P = .248). Indications for surgery (70.8% vs 70.8%; P = 1) and mortality (13.9% vs 16.7%; P = .741) were similar between groups. Conclusions. SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG.

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