Diversity of killer cell immunoglobulin-like receptor (KIR) genotypes and KIR2DL2/3 variants in HCV treatment outcome

The aim of this study was to analyse the distribution of KIR haplotypes and the KIR2DL2/3 alleles in chronic HCV-infected patients in order to establish the influence on the response to pegylated interferon plus ribavirin classical treatment. The alleles study of previously associated KIR2DL2/3 show...

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Detalles Bibliográficos
Autores: Vidal-Castiñeira, J.R. (Juan Ramón)|||/items/e2b5a04c-f49d-4693-b226-e354d9fb0a23, Lopez-Vazquez, A. (Antonio)|||/items/89143d8d-f1da-4069-925e-a22871e7c45a, Martinez-Borra, J. (Jesús)|||/items/a41eda6b-0fa0-435b-8a61-dc210629b3ca, Martinez-Camblor, P. (Pablo)|||/items/1f28b5f6-4801-4f8b-a1fe-576aa1a0a3c3, Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71, Lopez-Rodriguez, R. (Rosario)|||/items/d0dbdaa9-53c3-4df7-8961-62a513f6b941, Sanz-Cameno, P. (Paloma)|||/items/68196aaf-0530-4cf1-9121-346a5f28a9eb, Vega, J. (Juan) de la|||/items/008bd1f5-9261-4221-b947-580b9ae8f4e6, Rodrigo, L. (Luis)|||/items/f730e27c-c60b-4407-8f98-395c2eef806b, Perez-Lopez, R. (Rosa)|||/items/d22214dc-dbea-431d-a1ae-293dfc09deae, Perez-Alvarez, R. (Ramón)|||/items/1f39d919-b914-47c7-bd8b-f66079057627, Lopez-Larrea, C. (Carlos)|||/items/f36395a5-b258-4543-9043-555f14fc10e6
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/36214
Acceso en línea:https://hdl.handle.net/10171/36214
Access Level:acceso abierto
Palabra clave:KIR genotypes
KIR2DL2/3 alleles
Chronic HCV-infected patients
Pegylated interferon plus ribavirin
Treatment
Descripción
Sumario:The aim of this study was to analyse the distribution of KIR haplotypes and the KIR2DL2/3 alleles in chronic HCV-infected patients in order to establish the influence on the response to pegylated interferon plus ribavirin classical treatment. The alleles study of previously associated KIR2DL2/3 showed that KIR2DL2*001 was more frequent in non-SVR (NSVR) (42.2% vs. 27.5%, p<0.05) and KIR2DL3*001 was associated with sustained viral response (SVR) (41.6% vs. 61.2%, p<0.005). The KIR2DL3*001-HLA-C1 association was also significant (24.5% vs. 45.7%, p<0.001). From the frequencies of KIR obtained, 35 genotypes were assigned on the basis of previous studies. The centromeric A/A genotype was more frequent in SVR (44.1% vs. 34.5%, p<0.005) and the centromeric B/B genotype was found to be significantly more frequent in NSVR (20.9% vs. 11.2%, p<0.001). The logic regression model showed the importance of KIR genes in predicting the response to combined treatment, since the positive predictive value (PPV) was improved (from 55.9% to 75.3%) when the analysis of KIR was included in addition to the IFNL3 rs12979860 polymorphism. The study of KIR receptors may be a powerful tool for predicting the combined treatment response in patients with chronic HCV infection in association with the determination of IFNL3 polymorphism.

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