Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction

Background: Vasoconstrictor drugs reduce nitric oxide (NO) production in vitro by inhibiting the enzyme involved in the regulation of inducible and constitutive NO synthases (iNOS and cNOS). Intranasal vasoconstrictors also decrease nasal NO concentration in vivo. It is as yet unclear if this last f...

Full description

Bibliographic Details
Authors: Serrano, C., Valero, Antonio, Bartra Tomàs, Joan, Torrego, T., Mullol i Miret, Joaquim, Picado Vallés, César
Format: article
Status:Published version
Publication Date:2007
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/158582
Online Access:https://hdl.handle.net/2445/158582
Access Level:Open access
Keyword:Òxid nítric
Nas
Rinitis
Nitric oxide
Nose
Rhinitis
id ES_d49f8ac8d8d761667c64fd6121df82ca
oai_identifier_str oai:recercat.cat:2445/158582
network_acronym_str ES
network_name_str España
repository_id_str
spelling Effects on nasal nitric oxide production of 2 mechanisms of vasoconstrictionSerrano, C.Valero, AntonioBartra Tomàs, JoanTorrego, T.Mullol i Miret, JoaquimPicado Vallés, CésarÒxid nítricNasRinitisNitric oxideNoseRhinitisBackground: Vasoconstrictor drugs reduce nitric oxide (NO) production in vitro by inhibiting the enzyme involved in the regulation of inducible and constitutive NO synthases (iNOS and cNOS). Intranasal vasoconstrictors also decrease nasal NO concentration in vivo. It is as yet unclear if this last finding is due to the effects of the drug on the enzyme or on the vessels. Physical exercise also induces nasal vasoconstriction and reduces nasal resistance. Objectives: The aim of this study was to clarify the mechanisms involved in xylometazoline-induced reduction of nasal NO concentration. Methods: We compared 2 randomized groups of patients with moderate-severe persistent allergic rhinitis. The fi rst group (n=24) underwent a physiological nasal vasoconstrictor stimulus (exercise) whereas the second group (n=29) was treated with a nasal vasoconstrictor drug (topical xylometazoline). Nasal volume and NO were determined at baseline and 15 to 20 minutes after the end of each stimulus using acoustic rhinometry and chemiluminescence, respectively. Results: Baseline values of nasal volume and NO did not differ between the 2 groups. Nasal volume increased by 57% (P = .0001) after exercise and 71% (P = .0001) after xylometazoline. Nasal NO decreased (25%, P = .001) after xylometazoline, but not after exercise. Conclusion: Physical exercise and topical xylometazoline cause vasoconstriction and similar effects on nasal volume. In contrast nasal NO decreased with xylometazoline but not after exercise. These fi ndings suggest that vasoconstrictor drugs reduce nasal NO by mechanisms other than vasoconstriction.Esmon Publicidad S.A.2020202020072020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4 p.application/pdfhttps://hdl.handle.net/2445/158582Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://www.jiaci.org/summary/vol17-issue5-num260Journal of Investigational Allergology and Clinical Immunology, 2007, vol. 17, num. 5, p. 337-340(c) Esmon Publicidad S.A., 2007info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1585822026-05-29T05:05:01Z
dc.title.none.fl_str_mv Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction
title Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction
spellingShingle Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction
Serrano, C.
Òxid nítric
Nas
Rinitis
Nitric oxide
Nose
Rhinitis
title_short Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction
title_full Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction
title_fullStr Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction
title_full_unstemmed Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction
title_sort Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction
dc.creator.none.fl_str_mv Serrano, C.
Valero, Antonio
Bartra Tomàs, Joan
Torrego, T.
Mullol i Miret, Joaquim
Picado Vallés, César
author Serrano, C.
author_facet Serrano, C.
Valero, Antonio
Bartra Tomàs, Joan
Torrego, T.
Mullol i Miret, Joaquim
Picado Vallés, César
author_role author
author2 Valero, Antonio
Bartra Tomàs, Joan
Torrego, T.
Mullol i Miret, Joaquim
Picado Vallés, César
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Òxid nítric
Nas
Rinitis
Nitric oxide
Nose
Rhinitis
topic Òxid nítric
Nas
Rinitis
Nitric oxide
Nose
Rhinitis
description Background: Vasoconstrictor drugs reduce nitric oxide (NO) production in vitro by inhibiting the enzyme involved in the regulation of inducible and constitutive NO synthases (iNOS and cNOS). Intranasal vasoconstrictors also decrease nasal NO concentration in vivo. It is as yet unclear if this last finding is due to the effects of the drug on the enzyme or on the vessels. Physical exercise also induces nasal vasoconstriction and reduces nasal resistance. Objectives: The aim of this study was to clarify the mechanisms involved in xylometazoline-induced reduction of nasal NO concentration. Methods: We compared 2 randomized groups of patients with moderate-severe persistent allergic rhinitis. The fi rst group (n=24) underwent a physiological nasal vasoconstrictor stimulus (exercise) whereas the second group (n=29) was treated with a nasal vasoconstrictor drug (topical xylometazoline). Nasal volume and NO were determined at baseline and 15 to 20 minutes after the end of each stimulus using acoustic rhinometry and chemiluminescence, respectively. Results: Baseline values of nasal volume and NO did not differ between the 2 groups. Nasal volume increased by 57% (P = .0001) after exercise and 71% (P = .0001) after xylometazoline. Nasal NO decreased (25%, P = .001) after xylometazoline, but not after exercise. Conclusion: Physical exercise and topical xylometazoline cause vasoconstriction and similar effects on nasal volume. In contrast nasal NO decreased with xylometazoline but not after exercise. These fi ndings suggest that vasoconstrictor drugs reduce nasal NO by mechanisms other than vasoconstriction.
publishDate 2007
dc.date.none.fl_str_mv 2007
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/158582
url https://hdl.handle.net/2445/158582
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://www.jiaci.org/summary/vol17-issue5-num260
Journal of Investigational Allergology and Clinical Immunology, 2007, vol. 17, num. 5, p. 337-340
dc.rights.none.fl_str_mv (c) Esmon Publicidad S.A., 2007
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Esmon Publicidad S.A., 2007
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4 p.
application/pdf
dc.publisher.none.fl_str_mv Esmon Publicidad S.A.
publisher.none.fl_str_mv Esmon Publicidad S.A.
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420563242418176
score 15,811543

Similar Items