LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries
Background: The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been s...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/190850 |
| Acceso en línea: | https://hdl.handle.net/2445/190850 |
| Access Level: | acceso abierto |
| Palabra clave: | Biòpsia Cirrosi hepàtica Diagnòstic per la imatge Biopsy Hepatic cirrhosis Diagnostic imaging |
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LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countriesGraupera, IsabelThiele, MajaMa, Ann T.Serra-Burriel, MiquelPich, JuditFabrellas i Padrès, NúriaCaballeria, Llorençde Knegt, Robert J.Grgurevic, IvicaReichert, MathiasRoulot, DominiqueSchattenberg, Jörn M.Pericàs, Juan M.Angeli, PaoloTsochatzis, Emmanuel A.Guha, Indra NeilGarcía Retortillo, MontserratMorillas Cunill, Rosa MaríaHernández, RosarioHoyo, JordiFuentes, MatildeMadir, AnitaJuanola Mayos, AdriàSoria, AnnaJuan, MartaCarol, MartaDiaz, AlbaDetlefsen, SönkeTorán, PereFournier, CélineLlorca, AnneNewsome, Phillip N.Manns, Michaelde Koning, Harry J.Serra-Burriel, FeliuCucchietti, FernandoArslanow, AnitaKorenjak, Markovan Kleef, LaurensFalcó, Josep LluisKamath, Patrick S.Karlsen, Tom H.Castera, LaurentLammert, FrankKrag, AleksanderGinès i Gibert, PereBiòpsiaCirrosi hepàticaDiagnòstic per la imatgeBiopsyHepatic cirrhosisDiagnostic imagingBackground: The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. Methods: This study aims to include 30,000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be performed to assess the cost-effectiveness and budget impact of such an intervention. The project is funded by the European Commission H2020 program. Discussion: This study comes at an especially important time, as the burden of chronic liver diseases is expected to increase in the coming years. There is consequently an urgent need to change our current approach, from diagnosing the disease late when the impact of interventions may be limited to diagnosing the disease earlier, when the patient is asymptomatic and free of complications, and the disease potentially reversible. Ultimately, the LiverScreen study will serve as a basis from which diagnostic pathways can be developed and adapted to the specific socio-economic and healthcare conditions in each country.BioMed Central2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/190850Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s12889-022-13724-6BMC Public Health, 2022, num. 22, p. 1385https://doi.org/10.1186/s12889-022-13724-6cc-by (c) Graupera, Isabel et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1908502026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries |
| title |
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries |
| spellingShingle |
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries Graupera, Isabel Biòpsia Cirrosi hepàtica Diagnòstic per la imatge Biopsy Hepatic cirrhosis Diagnostic imaging |
| title_short |
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries |
| title_full |
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries |
| title_fullStr |
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries |
| title_full_unstemmed |
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries |
| title_sort |
LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries |
| dc.creator.none.fl_str_mv |
Graupera, Isabel Thiele, Maja Ma, Ann T. Serra-Burriel, Miquel Pich, Judit Fabrellas i Padrès, Núria Caballeria, Llorenç de Knegt, Robert J. Grgurevic, Ivica Reichert, Mathias Roulot, Dominique Schattenberg, Jörn M. Pericàs, Juan M. Angeli, Paolo Tsochatzis, Emmanuel A. Guha, Indra Neil García Retortillo, Montserrat Morillas Cunill, Rosa María Hernández, Rosario Hoyo, Jordi Fuentes, Matilde Madir, Anita Juanola Mayos, Adrià Soria, Anna Juan, Marta Carol, Marta Diaz, Alba Detlefsen, Sönke Torán, Pere Fournier, Céline Llorca, Anne Newsome, Phillip N. Manns, Michael de Koning, Harry J. Serra-Burriel, Feliu Cucchietti, Fernando Arslanow, Anita Korenjak, Marko van Kleef, Laurens Falcó, Josep Lluis Kamath, Patrick S. Karlsen, Tom H. Castera, Laurent Lammert, Frank Krag, Aleksander Ginès i Gibert, Pere |
| author |
Graupera, Isabel |
| author_facet |
Graupera, Isabel Thiele, Maja Ma, Ann T. Serra-Burriel, Miquel Pich, Judit Fabrellas i Padrès, Núria Caballeria, Llorenç de Knegt, Robert J. Grgurevic, Ivica Reichert, Mathias Roulot, Dominique Schattenberg, Jörn M. Pericàs, Juan M. Angeli, Paolo Tsochatzis, Emmanuel A. Guha, Indra Neil García Retortillo, Montserrat Morillas Cunill, Rosa María Hernández, Rosario Hoyo, Jordi Fuentes, Matilde Madir, Anita Juanola Mayos, Adrià Soria, Anna Juan, Marta Carol, Marta Diaz, Alba Detlefsen, Sönke Torán, Pere Fournier, Céline Llorca, Anne Newsome, Phillip N. Manns, Michael de Koning, Harry J. Serra-Burriel, Feliu Cucchietti, Fernando Arslanow, Anita Korenjak, Marko van Kleef, Laurens Falcó, Josep Lluis Kamath, Patrick S. Karlsen, Tom H. Castera, Laurent Lammert, Frank Krag, Aleksander Ginès i Gibert, Pere |
| author_role |
author |
| author2 |
Thiele, Maja Ma, Ann T. Serra-Burriel, Miquel Pich, Judit Fabrellas i Padrès, Núria Caballeria, Llorenç de Knegt, Robert J. Grgurevic, Ivica Reichert, Mathias Roulot, Dominique Schattenberg, Jörn M. Pericàs, Juan M. Angeli, Paolo Tsochatzis, Emmanuel A. Guha, Indra Neil García Retortillo, Montserrat Morillas Cunill, Rosa María Hernández, Rosario Hoyo, Jordi Fuentes, Matilde Madir, Anita Juanola Mayos, Adrià Soria, Anna Juan, Marta Carol, Marta Diaz, Alba Detlefsen, Sönke Torán, Pere Fournier, Céline Llorca, Anne Newsome, Phillip N. Manns, Michael de Koning, Harry J. Serra-Burriel, Feliu Cucchietti, Fernando Arslanow, Anita Korenjak, Marko van Kleef, Laurens Falcó, Josep Lluis Kamath, Patrick S. Karlsen, Tom H. Castera, Laurent Lammert, Frank Krag, Aleksander Ginès i Gibert, Pere |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Biòpsia Cirrosi hepàtica Diagnòstic per la imatge Biopsy Hepatic cirrhosis Diagnostic imaging |
| topic |
Biòpsia Cirrosi hepàtica Diagnòstic per la imatge Biopsy Hepatic cirrhosis Diagnostic imaging |
| description |
Background: The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. Methods: This study aims to include 30,000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be performed to assess the cost-effectiveness and budget impact of such an intervention. The project is funded by the European Commission H2020 program. Discussion: This study comes at an especially important time, as the burden of chronic liver diseases is expected to increase in the coming years. There is consequently an urgent need to change our current approach, from diagnosing the disease late when the impact of interventions may be limited to diagnosing the disease earlier, when the patient is asymptomatic and free of complications, and the disease potentially reversible. Ultimately, the LiverScreen study will serve as a basis from which diagnostic pathways can be developed and adapted to the specific socio-economic and healthcare conditions in each country. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2445/190850 |
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https://hdl.handle.net/2445/190850 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
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Reproducció del document publicat a: https://doi.org/10.1186/s12889-022-13724-6 BMC Public Health, 2022, num. 22, p. 1385 https://doi.org/10.1186/s12889-022-13724-6 |
| dc.rights.none.fl_str_mv |
cc-by (c) Graupera, Isabel et al., 2022 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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cc-by (c) Graupera, Isabel et al., 2022 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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10 p. application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central |
| publisher.none.fl_str_mv |
BioMed Central |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869420562186502145 |
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15,81155 |