Breast cancer epidemiology: mammographic screening and molecular subtypes
The aim of this thesis is to carry out an in-depth study of various aspects of breast cancer epidemiology. Firstly, we have confirmed that DCIS incidence in Girona has increased over recent decades. Proportions of screen-detected cancers, interval cancers and non-screen-detected cancers during the s...
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| Format: | doctoral thesis |
| Status: | Published version |
| Publication Date: | 2015 |
| Country: | España |
| Institution: | CBUC, CESCA |
| Repository: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/289426 |
| Online Access: | http://hdl.handle.net/10803/289426 |
| Access Level: | Open access |
| Keyword: | Breast cancer Cancer de mama Mammographic screening Cribratge mamogràfic Cribado mamográfico Molecular sutypes Subtipus molecular Subtipos moleculares Biochemical markers Marcadors bioquímics Marcadores bioquímicos Incidence Incidència 616 |
| Summary: | The aim of this thesis is to carry out an in-depth study of various aspects of breast cancer epidemiology. Firstly, we have confirmed that DCIS incidence in Girona has increased over recent decades. Proportions of screen-detected cancers, interval cancers and non-screen-detected cancers during the start-up phase of the mammographic screening programme were found to be 42.2%, 5.8% and 52.2%, respectively. Secondly, we have found that luminal A-like was the most frequent subtype associated with the best survival rate, while triple-negative breast cancer was related to the lowest survival rate. Importantly, we have concluded that breast cancer molecular subtype defined by IHC biomarkers provides prognostic value, regardless of age, tumour size, histological grade, lymph node involvement and method of detection. Finally, we have demonstrated that method of detection also provides prognostic value regardless of age, tumour size, histological grade, lymph node involvement and breast cancer molecular subtype defined by IHC biomarkers. |
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